O PAPEL DA ATIVIDADE FÍSICA NA PREVENÇÃO DA PROGRESSÃO DA DOENÇA DE ALZHEIMER: UMA REVISÃO BIBLIOGRÁFICA
DOI:
https://doi.org/10.47820/recima21.v5i5.5197Palavras-chave:
Atividade física. Exercício físico. Prevenção. Doença de Alzheimer. Saúde cerebral.Resumo
Introdução: A doença de Alzheimer (DA) é uma forma comum de demência, representando um desafio crescente para a saúde pública devido ao envelhecimento da população. A atividade física tem sido estudada como uma intervenção potencial na prevenção e tratamento da DA. Objetivo: Esta revisão de literatura busca demonstrar o papel da atividade física na prevenção da progressão da DA. Métodos: Esta revisão bibliográfica foi conduzida por meio de uma busca sistemática na literatura científica publicada nos últimos 20 anos, abrangendo o período de 2004 a 2024, utilizando critérios de inclusão e exclusão específicos, e as bases de dados eletrônicas: PubMed, Web of Science, Scopus e Google Scholar. Resultados e Discussão: Evidências consistentes demonstraram uma associação inversa entre atividade física e risco de desenvolvimento de DA, com benefícios adicionais na função cognitiva em pacientes diagnosticados com a doença. Mecanismos neurobiológicos, como a redução da inflamação e a promoção da neuroplasticidade, podem contribuir para esses efeitos benéficos. No entanto, a adesão a programas de exercícios permanece um desafio, especialmente em populações vulneráveis. Conclusão: A atividade física emerge como uma intervenção promissora na prevenção e tratamento da DA, com potencial para melhorar a saúde cerebral e a qualidade de vida. Estratégias integradas e personalizadas são necessárias para maximizar os benefícios da atividade física em populações vulneráveis, destacando a importância de abordagens colaborativas entre profissionais de saúde.
Downloads
Referências
BARANOWSKI, Bradley J. et al. Healthy brain, healthy life: a review of diet and exercise interventions to promote brain health and reduce Alzheimer’s disease risk. Applied Physiology, Nutrition, and Metabolism, v. 45, n. 10, p. 1055-1065, 2020. DOI: https://doi.org/10.1139/apnm-2019-0910
BARNARD, Neal D. et al. Dietary and lifestyle guidelines for the prevention of Alzheimer's disease. Neurobiology of aging, v. 35, p. S74-S78, 2014. DOI: https://doi.org/10.1016/j.neurobiolaging.2014.03.033
BROOKMEYER, Ron et al. Forecasting the prevalence of preclinical and clinical Alzheimer's disease in the United States. Alzheimer's & Dementia, v. 14, n. 2, p. 121-129, 2018. DOI: https://doi.org/10.1016/j.jalz.2017.10.009
BROWN, B. M.; PEIFFER, J. J.; MARTINS, R. N. Multiple effects of physical activity on molecular and cognitive signs of brain aging: can exercise slow neurodegeneration and delay Alzheimer’s disease?. Molecular psychiatry, v. 18, n. 8, p. 864-874, 2013. DOI: https://doi.org/10.1038/mp.2012.162
CASS, Shane P. Alzheimer's disease and exercise: a literature review. Current sports medicine reports, v. 16, n. 1, p. 19-22, 2017. DOI: https://doi.org/10.1249/JSR.0000000000000332
CHANDRA, Sidhanth; SISODIA, Sangram S.; VASSAR, Robert J. The gut microbiome in Alzheimer’s disease: what we know and what remains to be explored. Molecular neurodegeneration, v. 18, n. 1, p. 9, 2023 DOI: https://doi.org/10.1186/s13024-023-00595-7
COTMAN, Carl W.; BERCHTOLD, Nicole C.; CHRISTIE, Lori-Ann. Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends in neurosciences, v. 30, n. 9, p. 464-472, 2007.
COTMAN, Carl W.; BERCHTOLD, Nicole C.; CHRISTIE, Lori-Ann. Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends in neurosciences, v. 30, n. 9, p. 464-472, 2007. DOI: https://doi.org/10.1016/j.tins.2007.06.011
DE LA ROSA, Adrian et al. Physical exercise in the prevention and treatment of Alzheimer's disease. Journal of sport and health science, v. 9, n. 5, p. 394-404, 2020. DOI: https://doi.org/10.1016/j.jshs.2020.01.004
DE MELO COELHO, Flávia Gomes et al. Physical exercise modulates peripheral levels of brain-derived neurotrophic factor (BDNF): a systematic review of experimental studies in the elderly. Archives of gerontology and geriatrics, v. 56, n. 1, p. 10-15, 2013. DOI: https://doi.org/10.1016/j.archger.2012.06.003
DESLANDES, Andréa et al. Exercise and mental health: many reasons to move. Neuropsychobiology, v. 59, n. 4, p. 191-198, 2009. DOI: https://doi.org/10.1159/000223730
DISHMAN, Rod K. et al. Neurobiology of exercise. Obesity, v. 14, n. 3, p. 345-356, 2006. DOI: https://doi.org/10.1038/oby.2006.46
ERICKSON, Kirk I. et al. Exercise training increases size of hippocampus and improves memory. Proceedings of the national academy of sciences, v. 108, n. 7, p. 3017-3022, 2011. DOI: https://doi.org/10.1073/pnas.1015950108
FERNÁNDEZ-CALLE, Rosalía et al. APOE in the bullseye of neurodegenerative diseases: Impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases. Molecular neurodegeneration, v. 17, n. 1, p. 62, 2022. DOI: https://doi.org/10.1186/s13024-022-00566-4
FORBES, Dorothy et al. Exercise programs for people with dementia. Cochrane database of systematic reviews, n. 4, 2015. DOI: https://doi.org/10.1002/14651858.CD006489.pub4
GINÉ-GARRIGA, Maria et al. The effect of functional circuit training on physical frailty in frail older adults: a randomized controlled trial. Journal of aging and physical activity, v. 18, n. 4, p. 401-424, 2010. DOI: https://doi.org/10.1123/japa.18.4.401
GOMES DA SILVA, Sérgio et al. Exercise-induced hippocampal anti-inflammatory response in aged rats. Journal of neuroinflammation, v. 10, p. 1-6, 2013. DOI: https://doi.org/10.1186/1742-2094-10-61
GREENWOOD, Benjamin N. et al. Long-term voluntary wheel running is rewarding and produces plasticity in the mesolimbic reward pathway. Behavioural brain research, v. 217, n. 2, p. 354-362, 2011. DOI: https://doi.org/10.1016/j.bbr.2010.11.005
GUZMAN-MARTINEZ, Leonardo et al. New frontiers in the prevention, diagnosis, and treatment of Alzheimer’s disease. Journal of Alzheimer's disease, v. 82, n. s1, p. S51-S63, 2021. DOI: https://doi.org/10.3233/JAD-201059
HAMER, Mark; CHIDA, Yoichi. Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence. Psychological medicine, v. 39, n. 1, p. 3-11, 2009. DOI: https://doi.org/10.1017/S0033291708003681
HENEKA, Michael T. et al. Neuroinflammation in Alzheimer's disease. The Lancet Neurology, v. 14, n. 4, p. 388-405, 2015.
HOLTMAAT, Anthony; SVOBODA, Karel. Experience-dependent structural synaptic plasticity in the mammalian brain. Nature Reviews Neuroscience, v. 10, n. 9, p. 647-658, 2009. DOI: https://doi.org/10.1038/nrn2699
HSU, Chun Liang et al. Aerobic exercise promotes executive functions and impacts functional neural activity among older adults with vascular cognitive impairment. British journal of sports medicine, v. 52, n. 3, p. 184-191, 2018. DOI: https://doi.org/10.1136/bjsports-2016-096846
INTLEKOFER, Karlie A.; COTMAN, Carl W. Exercise counteracts declining hippocampal function in aging and Alzheimer's disease. Neurobiology of disease, v. 57, p. 47-55, 2013. DOI: https://doi.org/10.1016/j.nbd.2012.06.011
ISO-MARKKU, Paula et al. Physical activity as a protective factor for dementia and Alzheimer’s disease: systematic review, meta-analysis and quality assessment of cohort and case–control studies. British Journal of Sports Medicine, v. 56, n. 12, p. 701-709, 2022. DOI: https://doi.org/10.1136/bjsports-2021-104981
KHALSA, Dharma Singh. Stress, meditation, and Alzheimer’s disease prevention: where the evidence stands. Journal of Alzheimer's Disease, v. 48, n. 1, p. 1-12, 2015. DOI: https://doi.org/10.3233/JAD-142766
KIVIPELTO, Miia et al. World‐Wide FINGERS Network: a global approach to risk reduction and prevention of dementia. Alzheimer's & dementia, v. 16, n. 7, p. 1078-1094, 2020.
LAM, Linda C. W. et al. A 1-year randomized controlled trial comparing mind body exercise (Tai Chi) with stretching and toning exercise on cognitive function in older Chinese adults at risk of cognitive decline. Journal of the American Medical Directors Association, v. 13, n. 6, p. 568. e15-568. e20, 2012. DOI: https://doi.org/10.1016/j.jamda.2012.03.008
LIVINGSTON, Gill et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. The Lancet, v. 396, n. 10248, p. 413-446, 2020. DOI: https://doi.org/10.1016/S0140-6736(20)30367-6
LOPEZ-ORTIZ, Susana et al. Exercise interventions in Alzheimer’s disease: A systematic review and meta-analysis of randomized controlled trials. Ageing Research Reviews, v. 72, p. 101479, 2021. DOI: https://doi.org/10.1016/j.arr.2021.101479
LYNCH, Chris. World Alzheimer Report 2019: Attitudes to dementia, a global survey: Public health: Engaging people in ADRD research. Alzheimer's & Dementia, v. 16, p. e038255, 2020. DOI: https://doi.org/10.1002/alz.038255
MACHADO, Annelisa Pimentel Rezende; CARVALHO, Izabella Oliveira; DA ROCHA SOBRINHO, Hermínio Maurício. Neuroinflamação na doença de Alzheimer. Revista brasileira militar de ciências, v. 6, n. 14, 2020. DOI: https://doi.org/10.36414/rbmc.v6i14.33
MAHALAKSHMI, B. et al. Possible neuroprotective mechanisms of physical exercise in neurodegeneration. International journal of molecular sciences, v. 21, n. 16, p. 5895, 2020. DOI: https://doi.org/10.3390/ijms21165895
MASOUMI, Javad et al. Apelin, a promising target for Alzheimer disease prevention and treatment. Neuropeptides, v. 70, p. 76-86, 2018. DOI: https://doi.org/10.1016/j.npep.2018.05.008
MCAULEY, Edward et al. Self-efficacy: implications for physical activity, function, and functional limitations in older adults. American journal of lifestyle medicine, v. 5, n. 4, p. 361-369, 2011. DOI: https://doi.org/10.1177/1559827610392704
MCGURRAN, Hugo et al. Prevention and treatment of Alzheimer’s disease: biological mechanisms of exercise. Journal of Alzheimer's Disease, v. 69, n. 2, p. 311-338, 2019. DOI: https://doi.org/10.3233/JAD-180958
MEE-INTA, Onanong; ZHAO, Zi-Wei; KUO, Yu-Min. Physical exercise inhibits inflammation and microglial activation. Cells, v. 8, n. 7, p. 691, 2019. DOI: https://doi.org/10.3390/cells8070691
MING, Yung et al. Association of oral health–related quality of life and Alzheimer disease: A systematic review. The Journal of prosthetic dentistry, v. 124, n. 2, p. 168-175, 2020. DOI: https://doi.org/10.1016/j.prosdent.2019.08.015
NIU, Hao et al. Prevalence and incidence of Alzheimer's disease in Europe: A meta-analysis. Neurología (English Edition), v. 32, n. 8, p. 523-532, 2017. DOI: https://doi.org/10.1016/j.nrleng.2016.02.009
NORTHEY, Joseph Michael et al. Exercise interventions for cognitive function in adults older than 50: a systematic review with meta-analysis. British journal of sports medicine, v. 52, n. 3, p. 154-160, 2018. DOI: https://doi.org/10.1136/bjsports-2016-096587
NORTON, Sam et al. Potential for primary prevention of Alzheimer's disease: an analysis of population-based data. The Lancet Neurology, v. 13, n. 8, p. 788-794, 2014. DOI: https://doi.org/10.1016/S1474-4422(14)70136-X
ÖHMAN, Hannareeta et al. Effects of exercise on cognition: the Finnish Alzheimer disease exercise trial: a randomized, controlled trial. Journal of the American Geriatrics Society, v. 64, n. 4, p. 731-738, 2016. DOI: https://doi.org/10.1111/jgs.14059
PAHLAVANI, Hamed Alizadeh. Exercise therapy to prevent and treat Alzheimer’s disease. Frontiers in Aging Neuroscience, v. 15, p. 1243869, 2023. DOI: https://doi.org/10.3389/fnagi.2023.1243869
PAILLARD, Thierry. Preventive effects of regular physical exercise against cognitive decline and the risk of dementia with age advancement. Sports medicine-open, v. 1, p. 1-6, 2015. DOI: https://doi.org/10.1186/s40798-015-0016-x
REHFELD, Kathrin et al. Dancing or fitness sport? The effects of two training programs on hippocampal plasticity and balance abilities in healthy seniors. Frontiers in human neuroscience, v. 11, p. 241673, 2017. DOI: https://doi.org/10.3389/fnhum.2017.00305
REITZ, Christiane; MAYEUX, Richard. Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers. Biochemical pharmacology, v. 88, n. 4, p. 640-651, 2014. DOI: https://doi.org/10.1016/j.bcp.2013.12.024
REN, Jianchang; XIAO, Haili. Exercise Intervention for Alzheimer’s Disease: Unraveling Neurobiological Mechanisms and Assessing Effects. Life, v. 13, n. 12, p. 2285, 2023. DOI: https://doi.org/10.3390/life13122285
ROLLAND, Yves et al. Exercise program for nursing home residents with Alzheimer's disease: A 1‐year randomized, controlled trial. Journal of the American Geriatrics Society, v. 55, n. 2, p. 158-165, 2007. DOI: https://doi.org/10.1111/j.1532-5415.2007.01035.x
ROSENDAHL, Erik et al. A randomized controlled trial of fall prevention by a high-intensity functional exercise program for older people living in residential care facilities. Aging clinical and experimental research, v. 20, p. 67-75, 2008. DOI: https://doi.org/10.1007/BF03324750
SILVA, Marcos Vinícius Ferreira et al. Alzheimer’s disease: risk factors and potentially protective measures. Journal of biomedical science, v. 26, p. 1-11, 2019. DOI: https://doi.org/10.1186/s12929-019-0524-y
SUJKOWSKI, Alyson et al. The protective role of exercise against age-related neurodegeneration. Ageing Research Reviews, v. 74, p. 101543, 2022. DOI: https://doi.org/10.1016/j.arr.2021.101543
TREVISAN, Kaynara et al. Theories of aging and the prevalence of Alzheimer’s disease. BioMed research international, v. 2019, 2019. DOI: https://doi.org/10.1155/2019/9171424
VOSS, Michelle W. et al. Bridging animal and human models of exercise-induced brain plasticity. Trends in cognitive sciences, v. 17, n. 10, p. 525-544, 2013. DOI: https://doi.org/10.1016/j.tics.2013.08.001
WANG, Minghui et al. Exercise suppresses neuroinflammation for alleviating Alzheimer’s disease. Journal of neuroinflammation, v. 20, n. 1, p. 76, 2023. DOI: https://doi.org/10.1186/s12974-023-02753-6
WINBLAD, Bengt et al. Defeating Alzheimer's disease and other dementias: a priority for European science and society. The Lancet Neurology, v. 15, n. 5, p. 455-532, 2016. DOI: https://doi.org/10.1016/S1474-4422(16)00062-4
WU, Chongyun et al. Effects of exercise training on anxious–depressive-like behavior in Alzheimer rat. Medicine and science in sports and exercise, v. 52, n. 7, p. 1456, 2020. DOI: https://doi.org/10.1249/MSS.0000000000002294
XIAO, Jinwen et al. 2023 China Alzheimer’s disease: facts and figures. Human Brain, v. 2, n. 3, 2023. DOI: https://doi.org/10.37819/hb.3.1771
ZEISEL, John; BENNETT, Kirsty; FLEMING, Richard. World Alzheimer Report 2020: Design, dignity, dementia: Dementia-related design and the built environment. London, England: Alzheimer’s Disease International, 2020.
ZHANG, Shiyan et al. The effect of aerobic exercise on cognitive function in people with Alzheimer’s disease: A systematic review and meta-analysis of randomized controlled trials. International journal of environmental research and public health, v. 19, n. 23, p. 15700, 2022. DOI: https://doi.org/10.3390/ijerph192315700
ZHANG, X.-X. et al. The epidemiology of Alzheimer’s disease modifiable risk factors and prevention. The journal of prevention of Alzheimer's disease, v. 8, p. 313-321, 2021.
ZONG, Boyi et al. Understanding how physical exercise improves Alzheimer’s disease: cholinergic and monoaminergic systems. Frontiers in Aging Neuroscience, v. 14, p. 869507, 2022. DOI: https://doi.org/10.3389/fnagi.2022.869507
Downloads
Publicado
Como Citar
Licença
Copyright (c) 2024 RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Os direitos autorais dos artigos/resenhas/TCCs publicados pertecem à revista RECIMA21, e seguem o padrão Creative Commons (CC BY 4.0), permitindo a cópia ou reprodução, desde que cite a fonte e respeite os direitos dos autores e contenham menção aos mesmos nos créditos. Toda e qualquer obra publicada na revista, seu conteúdo é de responsabilidade dos autores, cabendo a RECIMA21 apenas ser o veículo de divulgação, seguindo os padrões nacionais e internacionais de publicação.