ATUALIZAÇÃO SOBRE OS BIOMARCADORES PRECOCES DO INFARTO AGUDO DO MIOCÁRDIO E SUAS RELAÇÕES COM A TROPONINA CARDÍACA: UMA REVISÃO DE LITERATURA

Autores

DOI:

https://doi.org/10.47820/recima21.v5i8.5497

Palavras-chave:

Síndrome coronariana aguda, sensibilidade e especificidade dos biomarcadores, isquemia miocárdica, diagnóstico precoce IAM

Resumo

As doenças cardiovasculares são responsáveis por quase metade de todas as mortes em todo o mundo, sendo, portanto, as causas mais comuns de óbito e, por isso, deve-se atentar a esse tipo de manifestação clínica, posto que cerca de 10% dos pacientes que relatam dor torácica ao chegarem ao pronto-socorro são diagnosticados com infarto agudo do miocárdio (IAM). Objetivo: Este estudo teve como objetivo analisar os principais biomarcadores prévios do infarto agudo do miocárdio, a fim de evidenciar o melhor diagnóstico deste quadro emergencial. Metodologia: Trata-se de uma Revisão de Literatura Descritiva, realizada por meio do banco de dados do Portal da Capes. Os descritores utilizados foram: [hypertensive adult] AND [new biomarkers] AND [sensitivity] OR [specificity] AND [early diagnosis] AND [acute myocardial infarction]. Resultado: A troponina precisa de repetidas dosagens para um diagnóstico conciso; a CK-MB apresentou sensibilidade próxima a 40% e especificidade de 90%; a copeptina atinge o pico plasmático em 0 a 1 hora depois do início dos sintomas. O miRNA apresentou especificidade de 82% e sensibilidade de 78%. A mioglobina apresentou baixa especificidade e alta sensibilidade, o que não é favorável ao bom diagnóstico. Os neutrófilos e plasmócitos migram para a área isquêmica. A albumina e o H-FABP apresentaram alta sensibilidade e especificidade. Conclusão: Os marcadores bioquímicos do infarto analisados nesta revisão, troponina, CK-MB, copeptina, miRNA, H-FABP, Myo, neutrófilos e plasmócitos, e albumina, não obtiveram um excelente parâmetro no diagnóstico quando analisados separadamente porém, observou-se que a correlação dos indicadores melhora o prognóstico do IAM.

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Biografia do Autor

Paula Rayssa Rodrigues

UNIFENAS - Universidade Professor Edson Antônio Velano.

Gabriel Santiago de Faria

UNIFENAS - Universidade Professor Edson Antônio Velano.

Alessandra Cristina Pupin Silvério

UNIFENAS - Universidade Professor Edson Antônio Velano.

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Publicado

29/07/2024

Como Citar

Rodrigues, P. R., de Faria, G. S., & Silvério , A. C. P. (2024). ATUALIZAÇÃO SOBRE OS BIOMARCADORES PRECOCES DO INFARTO AGUDO DO MIOCÁRDIO E SUAS RELAÇÕES COM A TROPONINA CARDÍACA: UMA REVISÃO DE LITERATURA . RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, 5(8), e585497. https://doi.org/10.47820/recima21.v5i8.5497