IMMUNOLOGICAL ASPECTS ASSOCIATED WITH GASTRIC PROTECTION AGAINST Helicobacter pylori INFECTION: ROLE OF CD4 (+) T LYMPHOCYTES VIA FOXP3 EXPRESSION
DOI:
https://doi.org/10.47820/recima21.v3i3.1212Keywords:
Helicobacter pylori, Immunology, Regulatory Lymphocytes T, Gastric ulcer, FOXP3Abstract
Helicobacter pylori is a Gram-negative bacterium that induces continuous inflammation in the gastric mucosa through the contribution of CD3+ and CD4+ T cells, causing several types of lesions such as: chronic gastritis, peptic ulcer and gastric cancer. As a result, T cells transfected with the Foxp3 gene involved in the inflammatory process begin to express regulatory cellular properties. This work aims to review the literature on the immunological aspects involved in gastric protection against H. pylori infection. Literature review carried out by searching articles in PubMed, Lilacs, MedLine and Scielo databases, using the keywords: “Helicobacter pylori”; "Immunology"; “Regulatory T lymphocytes”; “Gastric Ulcer” and the term “FOXP3”.
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