TAKOTSUBO SYNDROME INDUCED BY IMMUNE CHECKPOINT INHIBITORS

Authors

DOI:

https://doi.org/10.47820/recima21.v3i10.1995

Keywords:

Cardiotoxicity, Myocardiopathy, Agents Cancer Chemotherapy

Abstract

Introduction: Takotsubo syndrome (ST) is an acute cardiac syndrome characterized by typical regional wall motion abnormalities that reflect impaired myocardial contractility leading to acute heart failure in the absence of epicardial coronary artery disease. The exact etiology is not known, however, an apparent relationship is noted between the use of immune checkpoint inhibitors (ICIs) and the diagnosis of ST. Objective: To clarify the relationship between ICIs and ST, considering it to be an extremely important topic for health professionals. Materials and methods: The literature search was performed by consulting the PubMed electronic database, starting with "takotsubo syndrome" and "immune checkpoint inhibitor therapy". We delimited articles published between 2003 and 2022, with studies that answered the guiding question previously defined. After applying the inclusion and exclusion criteria, a final sample of 6 studies was obtained for the integrative review. Results and discussion: Immune checkpoint inhibitors are increasingly used to treat certain malignancies due to their greater efficacy compared to conventional chemotherapy. ICIs become toxic due to the removal of self-tolerance, which in turn induces autoimmune processes. Conclusion: In summary, this study makes it clear that, based on the currently available literature, one can conclude an association between ICIs and ST, especially when the ICI used is 5-fluorouracil.

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Author Biographies

  • Letícia Bueno de Alckmim Morais

    Letícia Bueno de Alckmim Morais, 32 years old, medical student at the José do Rosário Vellano University - UNIFENAS, currently an academic in the twelfth semester.

  • Carollayne Mendonça Rocha

    Universidade José do Rosário Vellano - UNIFENAS

  • Dayana Bomfim Santos

    Dayana Bomfim Santos, 26 years old, medical student at the José do Rosário Vellano University - UNIFENAS, currently an academic in the 12th period.

  • Ênio Ázara Oliveira

    Ênio Ázara de Oliveira, 25 years old, medical student at the José do Rosário Vellano University - UNIFENAS, currently an academic in the 12th period.

  • Gabriela Resende de Carvalho Ferraz

    Gabriela Resende de Carvalho Ferraz, 27 years old, medical student at the José do Rosário Vellano University - UNIFENAS, currently an academic in the twelfth semester.

  • Gabriel Henrique Ferracioli Alvarenga

    Currently Graduating in Medicine at José do Rosário Vellano University (UNIFENAS - Alfenas - Minas Gerais) since 2019 - currently in the eighth period. In 2019, he was a room representative in the first semester. In 2020 he was scientific coordinator of the Academic League of Ophthalmology, Vice President of the Nutrology League, President of the Diabetes I Care Extension Project, monitor of ANATOMY I and EMBRYOLOGY also in 2020.

  • Gustavo Alex Silva

    Gustavo Alex Silva, 27 years old, medical student at the José do Rosário Vellano University - UNIFENAS, currently an academic in the twelfth semester.

  • Gustavo de Almeida Xavier

    Gustavo de Almeida Xavier, 33 years old, student at the José do Rosário Vellano University - Unifenas- currently in the eleventh period.

  • Juliana Reis Silva

    Juliana Reis Silva, 32 years old, medical student at the José do Rosário Vellano University - UNIFENAS, currently an eleventh-year academic.

  • Lara da Silva Paiva

    Lara da Silva Paiva, 26 years old, medical student at the Centro Universitário das Américas - FAM, currently an academic in the twelfth semester.

  • Luiz Otávio Paiva Flausino

    Luiz Otávio Paiva Flausino, 24 years old, doctor graduated from the José do Rosário Vellano University - UNIFENAS

  • Natália Iohana Breña Fortunato

    Natália Iohana Breña Fortunato, 26 years old, medical student at the José do Rosário Vellano University - UNIFENAS, currently a 7th-year academic.

  • Nathália Callegari Peraro

    Nathália Callegari Peraro, 25 years old, medical student at the José do Rosário Vellano University - UNIFENAS, currently a 12 period academic.

  • Thiago Milani Muniz de Souza

    Thiago Milani Muniz de Souza, 26 years old, medical student at the José do Rosário Vellano University - UNIFENAS, currently an eleventh semester student.

  • Wesley Ramires de Souza Liberato

    Wesley Ramires de Souza Liberato, 23 years old, medical student at the José do Rosário Vellano University - UNIFENAS, currently an academic in the twelfth period.

References

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EDERHY, Stephane et al. Takotsubo-like syndrome in cancer patients treated with immune checkpoint inhibitors. JACC: Cardiovascular Imaging, v. 11, n. 8, p. 1187-1190, 2018.

MICHEL, Lars; RASSAF, Tienush; TOTZECK, Matthias. Cardiotoxicity from immune checkpoint inhibitors. IJC Heart & Vasculature, v. 25, p. 100420, 2019.

DESAI, Aakash et al. Takotsubo cardiomyopathy in cancer patients. Cardio-oncology, v. 5, n. 1, p. 1-16, 2019.

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CARBONE, Andreina et al. Takotsubo cardiomyopathy as epiphenomenon of cardiotoxicity in patients with cancer: a meta-summary of case reports. Journal of Cardiovascular Pharmacology, v. 78, n. 1, p. e20-e29, 2021.

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Published

04/10/2022

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Vol. 3 No. 10 (2022): EDITORIAL - CLICK HERE TO ACCESS THE ARTICLES

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TAKOTSUBO SYNDROME INDUCED BY IMMUNE CHECKPOINT INHIBITORS. (2022). RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, 3(10), e3101995. https://doi.org/10.47820/recima21.v3i10.1995