ANOREXIA NERVOSA AND INTESTINAL MICROBIOME: A RELATIONSHIP THAT NEEDS TO BE STUDIED
DOI:
https://doi.org/10.47820/recima21.v4i1.2593Keywords:
Anorexia Nervosa, Gastrointestinal Microbiome, Inflammation, EatingAbstract
Introduction: Eating disorders are established as a public health problem due to somatic and psychiatric complications, in this scenario, an increase in the number of cases of anorexia nervosa is perceived. Thus, it is perceived that the intestinal microbiota is mechanically involved in changes in physiological function throughout the etiology, progression and treatment of eating disorders.
Objective: To point out the possible relationship between the intestinal microbiome in the progression
and exacerbation of symptoms related to anorexia nervosa. Method: A bibliographic survey was carried out in the Medical Literature Analysis and Retrieval Sistem online database, covering the
following phases: elaboration of the guiding question, literature search, data collection, critical analysis of the included studies, discussion of the results and presentation of the integrative review. From the following descriptors in English, anorexia nervosa, gastrointestinal microbiome, inflammation and food
consumption, a total of twenty-six articles were obtained for this article. Results and discussion: Interactions between feeding behavior and the microbiome modulate host behavior. When referring to
anorexia nervosa, factors such as increased intestinal permeability, presence of low-grade inflammation, autoantibodies and neogenesis are related to some depressive, anxious and eating
disorder symptoms, therefore, factors that contribute to the maintenance of the frame. Conclusion: Thus, a possible relationship between anorexia nervosa and intestinal microbiota is suggested, either
in the maintenance and/or treatment of the condition, so that the modulation of the intestinal microbiota can be useful to change the natural history of eating disorders, including of anorexia
nervosa.
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References
ALCKMIN-CARVALHO, Felipe et al. Análise da evolução dos critérios diagnósticos da anorexia
nervosa. Avaliação Psicológica, v. 15, n. 2, p. 265-274, 2016.
American Psychiatric Association. Manual diagnóstico e estatístico de transtornos mentais. Tradução
de Maria Inês Corrêa Nascimento... et al.]. Porto Alegre: Artmed, p. 329-341, 2014.
BORGO, Francesca et al. Microbiota in anorexia nervosa: the triangle between bacterial species,
metabolites and psychological tests. PLoS One, v. 12, n. 6, p. e0179739, 2017.
CARBONE, Elvira Anna et al. A systematic review on the role of microbiota in the pathogenesis and
treatment of eating disorders. European Psychiatry, v. 64, n. 1, 2021.
CORRAL, Andrea et al. Trastornos de la alimentación en pacientes hospitalizados en um Servicio de
Salud Mental Pediátrico. Revista chilena de pediatría, v. 90, n. 3, p. 302-308, 2019.
DALTON, Bethan et al. Inflammatory markers in anorexia nervosa: an exploratory study. Nutrients, v.
, n. 11, p. 1573, 2018.
DINAN, Timothy G.; CRYAN, John F. Gut instincts: microbiota as a key regulator of brain
development, ageing and neurodegeneration. The Journal of physiology, v. 595, n. 2, p. 489-503,
GALMICHE, Marie et al. Prevalence of eating disorders over the 2000–2018 period: a systematic
literature review. The American journal of clinical nutrition, v. 109, n. 5, p.1402-1413, 2019.
GRIGIONI, Sébastien et al. Intestinal permeability and appetite regulating peptides-reactive
immunoglobulins in severely malnourished women with anorexia nervosa. Clinical Nutrition, v. 41, n. 8,
p. 1752-1758, 2022.
HANACHI, Mouna et al. Micronutrients deficiencies in 374 severely malnourished anorexia nervosa
inpatients. Nutrients, v. 11, n. 4, p. 792, 2019.
HERPERTZ-DAHLMANN, Beate; DAHMEN, Brigitte. Children in need—Diagnostics, epidemiology,
treatment and outcome of early onset anorexia nervosa. Nutrients, v. 11, n.8, p. 1932, 2019.
JAITE, Charlotte et al. Clinical Characteristics of Inpatients with Childhood vs. Adolescent Anorexia
Nervosa. Nutrients, v. 11, n. 11, p. 2593, 2019.
KANAYAMA, Shunsuke et al. Childhood dietary intake: Comparison between anorexia nervosa and
healthy leanness. Pediatrics International, v. 61, n. 1, p. 73-79, 2019.
KLEIMAN, Susan C. et al. Gut feelings: a role for the intestinal microbiota in anorexia nervosa?. The
International journal of eating disorders, v. 48, n. 5, p. 449, 2015.
KLEIMAN, Susan C. et al. Daily changes in composition and diversity of the intestinal microbiota in
patients with anorexia nervosa: a series of three cases. European Eating Disorders Review, v. 25,
n. 5, p. 423-427, 2017.
LAM, Yan Y. et al. Are the gut bacteria telling us to eat or not to eat? Reviewing the role of gut
microbiota in the etiology, disease progression and treatment of eating disorders. Nutrients, v. 9, n. 6,
p. 602, 2017.
MACK, Isabelle et al. Weight gain in anorexia nervosa does not ameliorate the faecal microbiota,
branched chain fatty acid profiles and gastrointestinal complaints. Scientific reports, v. 6, n. 1, p. 1-
, 2016.
MITHIEUX, Gilles. Gut microbiota and host metabolism: what relationship. Neuroendocrinology, v.
, n. 4, p. 352-356, 2018.
NAKAI, Yoshikatsu; NIN, Kazuko; NOMA, Shunichi. Eating disorder symptoms among Japanese
female students in 1982, 1992 and 2002. Psychiatry research, v. 219, n. 1, p. 151-156, 2014.
NAVARRO-TAPIA, Elisabet et al. Effects of microbiota imbalance in anxiety and eating disorders:
probiotics as novel therapeutic approaches. International journal of molecular sciences, v. 22, n. 5, p.
, 2021.
RAATZ, Susan K. et al. Nutritional adequacy of dietary intake in women with anorexia nervosa.
Nutrients, v. 7, n. 5, p. 3652-3665, 2015.
RUUSUNEN, Anu et al. The gut microbiome in anorexia nervosa: relevance for nutritional
rehabilitation. Psychopharmacology, v. 236, n. 5, p. 1545-1558, 2019.
SEITZ, Jochen et al. Gut Feelings: How Microbiota Might Impact the Development and Course of
Anorexia Nervosa. Nutrients, v. 12, n. 11, p. 3295, 2020.
SOUZA, Marcela Tavares de; SILVA, Michelly Dias da; CARVALHO, Rachel de. Revisão integrativa: o
que é e como fazer. Einstein (São Paulo), v. 8, p. 102-106, 2010.
STEINHAUSEN, Hans‐Christoph; JENSEN, Christina Mohr. Time trends in lifetime incidence rates of
first‐time diagnosed anorexia nervosa and bulimia nervosa across 16 years in a Danish nationwide
psychiatric registry study. International Journal of Eating Disorders, v. 48, n. 7, p. 845-850, 2015.
VAN DE WOUW, Marcel et al. Microbiota-gut-brain axis: modulator of host metabolism and appetite.
The Journal of nutrition, v. 147, n. 5, p. 727-745, 2017.
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