PHARMACOLOGICAL TREATMENT FOR GASTROESOPHAGEAL REFLUX DISEASE (GERD) IN PEDIATRIC PATIENTS

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DOI:

https://doi.org/10.47820/recima21.v4i1.2633

Keywords:

GERD is a condition of uncomfortable symptoms and complications

Abstract

Introduction: GERD is a condition of uncomfortable symptoms and complications that result from the reflux of stomach contents into the esophagus. Studies suggest that it occurs in about 50% of infants younger than 2 months of age, 60 to 70% of infants aged 3 to 4 months, and 5% of infants aged 12 months. The aim is to gather evidence to confirm the safety of drug treatment for GERD in children. Materials and methods: The research was carried out using the following descriptors: “gastroesophageal reflux diseases”, “children” and “drug treatment” combined with Boolean operators. By applying all the inclusion and exclusion criteria, a sample of 5 articles was obtained. Results and discussion: Drug treatment of GERD basically consists of proton pump inhibitor drugs (PPIs), which block the final step of gastric acid release due to inhibition of the H+/K+-ATPase enzyme. Regarding the association of non-drug methods to acid suppression therapy, a randomized clinical trial was carried out with the aim of clarifying the superiority of the combined treatment. Conclusion: It is concluded that treatment with PPIs and even the off-label use of metoclopramide can be beneficial as anti-reflux therapy in the pediatric population.

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Author Biographies

  • Estela de Oliveira Rodrigues, Universidade José do Rosário Vellano - UNIFENAS

    Acadêmica de Medicina na Universidade José do Rosário Vellano - UNIFENAS, do sexto período.

  • Afonso Vilela Neves Júnior, Universidade José do Rosário Vellano - UNIFENAS

    Acadêmico de Medicina na Universidade José do Rosário Vellano - UNIFENAS, do nono período.

  • Amanda Carolline Couto, UNIPAC- Centro Universitário Presidente Antonio Carlos

    Acadêmica de Medicina na UNIPAC- Centro universitário presidente Antônio Carlos , do quinto período.

  • Camila de Alencastro Costa Moreira , Faculdade Municipal Professor Franco Montoro

    Acadêmica de Medicina na Universidade Municipal Franco Montoro - FMPFM, do segundo período.

  • Elisangela Vaz Kochhann, Centro Universitário de Jaguariúna

    Acadêmica de Medicina no Centro Universitário de Jaguariúna.

  • Giovani Caiolli Noel Scapin Santos, Universidade José do Rosário Vellano - UNIFENAS

    Acadêmico de Medicina na Universidade José do Rosário Vellano - UNIFENAS, do décimo primeiro período.

  • Isabella Loiola Lima, Universidade José do Rosário Vellano - UNIFENAS

    Médica formada pela Universidade José do Rosário Vellano - UNIFENAS.

  • Izadora Pires de Oliveira, Universidade José do Rosário Vellano - UNIFENAS

    Acadêmica de Medicina na Universidade José do Rosário Vellano - UNIFENAS, do sétimo período.

  • Marina Santana Fonseca, Associação São Francisco de Assis

    Graduada pela Unifenas, residente em Cirurgia Geral pela Associação São Francisco de Assis (Hospital Cemil), Umuarama-PR.

  • Carollayne Mendonça Rocha, Universidade José do Rosário Vellano - UNIFENAS

    Universidade José do Rosário Vellano - UNIFENAS.

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15/01/2023

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Vol. 4 No. 1 (2023): EDITORIAL - CLICK HERE TO ACCESS THE ARTICLES

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How to Cite

PHARMACOLOGICAL TREATMENT FOR GASTROESOPHAGEAL REFLUX DISEASE (GERD) IN PEDIATRIC PATIENTS. (2023). RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, 4(1), e412633. https://doi.org/10.47820/recima21.v4i1.2633