EFFECTIVENESS OF PLATELET-RICH PLASMA FOR THE TREATMENT OF ANDROGENETIC ALOPECIA
DOI:
https://doi.org/10.47820/recima21.v4i10.4194Keywords:
Alopecia, Minoxidil, Trichology.Abstract
Introduction: Androgenetic alopecia (AGA) is a multifactorial dermatological pathology, of polygenic origin, characterized by alteration of the hair cycle, leading to progressive follicular miniaturization, which leaves the terminal hairs thinner. Objectives: to evaluate the efficacy and side effects of treatment with platelet-rich plasma in patients with AGA. Materials and methods: This is an integrative review, in which the guiding question was “Is platelet-rich plasma effective in the treatment of androgenetic alopecia?”. The search for articles took place in the PubMed database using the terms “efficacy”, “platelet-rich plasma”, “treatment” and “androgenetic alopecia”, combined with each other using the Boolean operator AND. Results and discussion: The results showed that PRP is effective in treating AGA, without major side effects. Of the 13 articles analyzed, 4 compared the effectiveness of PRP therapy in relation to Minoxidil, one of which analyzed the two substances in combined therapy. Comparative studies between PRP and Minoxidil showed that both were well tolerated and effective. A meta-analysis that sought to identify the effectiveness of PRP monotherapy in men and women separately, evaluating capillary density and diameter, PRP significantly increased capillary diameter in both sexes, but capillary density was significantly increased only in males. Conclusion: Most of the studies analyzed in this review showed positive results regarding the use of PRP in AGA, both in males and females.
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References
STARACE, M. et al. Female Androgenetic Alopecia: An Update on Diagnosis. American Journal of Clinical Dermatology, Novembro 2019. 1-16.
LOLLI, F. et al. Androgenetic alopecia: a review. Endocrine, 17, n. 1, 28 Março 2017. 1-9.
DEVJANI, S. et al. Androgenetic Alopecia: Therapy Update. Drugs, 83, 11 Maio 2023. 701-715.
KANTI, V. et al. Evidence-based (S3) guideline for the treatment of androgenetic alopecia in women and in men – short version. Journal of the European Academy of Dermatology and Venereology., 32, Janeiro 2018. 11-22.
PREMANAND, A.; RAJKUMARI, B. R. n silico analysis of gene expression data from bald frontal and haired occipital scalp to identify candidate genes in male androgenetic alopecia. Arch Dermatol Res., 311, n. 10, Dezembro 2019. 815-824.
MULINARI-BRENNER, F.; SEIDE, G.; HEPP., T. Entendendo a alopecia androgenética. Surg Cosmet Dermatol., 3, n. 4, 2011. 329-337.
BULLOS, B. S. et al. Alopecia androgenética e seus tratamentos alternativos: uma revisão. Revista Eletrônica Acervo Médico, Rio de Janeiro, 6, Abril 2022. 1-6.
DE-EKNAMKUL., R. J. &. W. Potential targets in the discovery of new hair growth promoters for androgenic alopecia. Ruchy Jain & Wanchai De-Eknamkul., 18, n. 7, 2014. 787-806.
COHEN, C. A. M. F.; VIEIRA, J. F. Fisiopatologia de alopécia androgenética: uma revisão da literatura. Revista Saber Científico., Porto Velho, Novembro 2018.
PHILLIPS, T. G.; SLOMIANY, W. P.; ALLISON, R. Hair Loss: Common Causes and Treatment, American Family Physician, 96, n. 6, 15 Setembro 2017. 371-378.
GUPTA, A. K.; FOLEY, K. A. A Critical Assessment of the Evidence for Low-Level Laser Therapy in the Treatment of Hair Loss. Dermatologic Surgery, 43, n. 2, Fevereiro 2017. 188-197.
SINCLAIR, R. D. Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone. Int J Dermatol, 57, n. 1, Janeiro 2018. 104-109.
GUPTA, A. K. et al. Relative Efficacy of Minoxidil and the 5-α Reductase Inhibitors in Androgenetic Alopecia Treatment of Male Patients: A Network Meta-analysis. JAMA Dermatol., 158, n. 3, Março 2022. 266-274.
CERVANTES, J. et al. Effectiveness of Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature. Skin Appendage Disord., 4, n. 1, Janeiro 2018. 1-11.
GUPTA, A. K.; RENAUD, H. J.; M., B. Platelet-rich plasma for androgenetic alopecia: Efficacy differences between men and women. Dermatol Ther., 33, n. 6, 2020.
GENTILE, P.; GARCOVICH, S. Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil®, Finasteride®, and Adult Stem Cell-Based Therapy.. Int J Mol Sci., 21, n. 8, Apr. 2020.
ASEEM SHARMA, A. et al. Platelet-Rich Plasma in Androgenetic Alopecia. Indian Dermatol Online J., 12, n. 1, Nov. 2021. 31-40.
GENTILE, P.; GARCOVICH, S. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development. Cells, 8, n. 5, May 2019.
GENTILE, P. et al. The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial. Stem Cells Transl Med., 4, n. 11, Nov. 2015. 1317-23.
SHARMA, A. et al. Platelet-rich plasma in androgenetic alopecia. Indian Dermatol Online J, 12, 2021. 31-40.
ERCOLE, F. F.; MELO, L. S. D.; ALCOFORADO, C. L. G. C. Revisão integrativa versus revisão sistemática. Reme: Revista Mineira de Enfermagem, 18, n. 1, 2014. 09-11.
MENDES, K. D. S.; SILVEIRA, R. C. C. P.; GALVÃO, C. M. Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto & contexto-enfermagem, 17, 2008. 758-764.
SOUZA, L. M. M. et al. A metodologia de revisão integrativa da literatura em enfermagem. Revista investigação em enfermagem, 21, n. 2, 2017. 17-26.
GRESSENBERGER, P. et al. Platelet-rich Plasma for Androgenetic Alopecia Treatment: A Randomized Placebo-controlled Pilot Study. Acta Derm Venereol., 100, n. 15, Aug. 2020.
PAKHOMOVA, E. E.; SMIRNOVA, I. O. Comparative Evaluation of the Clinical Efficacy of PRP-Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia. Int J Mol Sci., 21, n. 18, Sep. 2020.
OLIVEIRA, A. F. Q. et al. Use of autologous platelet-rich plasma in androgenetic alopecia in women:a systematic review and meta-analysis. Journal Of Dermatological Treatment, 34, n. 1, 2023. 1-11.
VERMA, K. et al. A Study to Compare the Efficacy of Platelet-rich Plasma and Minoxidil Therapy for the Treatment of Androgenetic Alopecia. Int J Trichology., 11, n. 2, Mar-Apr. 2019.
BALASUNDARAM, M.; KUMARI, R.; RAMASSAMY, S. Efficacy of autologous platelet-rich plasma therapy versus topical Minoxidil in men with moderate androgenetic alopecia: a randomized open-label trial. 2023 Dec;34(1). J Dermatolog Treat., 34, n. 1, Dec. 2023.
HAN, J. H. et al. Effect of minoxidil on proliferation and apoptosis in dermal papilla cells of human hair follicle. J. Dermatol. Sci., 34, 2004. 91-98.
SEMALTY, M. et al. Hair growth and rejuvenation: An overview. J. Dermatol. Treat. , 22, 2010. 123-132.
ALVES, R.; GRIMALT, R. Platelet-Rich Plasma in Combination With 5% Minoxidil Topical Solution and 1 mg Oral Finasteride for the Treatment of Androgenetic Alopecia. Dermatologic Surgery., 1, 2017. 1-4.
VAN NESTE, D. et al. Finasteride increases anagen hair in men with androgenetic alopecia. Br. J. Dermatol. 2000, 143, 2000. 804-810.
CHAVES, R. L. et al. Opções terapêuticas e perspectivas no tratamento da alopecia androgenética. Revista Eletrônica Acervo Científico, 25, 2021. 1-7.
STARACE, M. et al. Female androgenetic alopecia: an update on diagnosis and management. Am J Clin Dermatol., 21, n. 1, 2020. 69-84.
LEVY-NISSENBAUM, E. et al. Confirmation of the association between male pattern baldness and the androgen receptor gene. Eur J Dermatol., 15, n. 5, 2005. 339-340.
MERCURI, S. R. et al. Investigating the Safety and Efficacy of Platelet-Rich Plasma (PRP) Treatment for Female Androgenetic Alopecia: Review of the Literature.. Medicina (Kaunas)., 57, n. 4, Mar. 2021.
ZHOU, S. et al. Platelet-Plasma in Female Androgenic Alopecia: A Comprehensive Systematic Review and Meta-Analysis. Front Pharmacol., 6, May 2021.
PATHTHINIGE, N. D.; AKARAWITA, J. K. W.; JEGANATHAN, G. The Clinical Efficacy and Safety of Autologous Activated Platelet-Rich Plasma Injection in Androgenetic Alopecia. Skin Appendage Disord., 6, n. 1, Jan. 2020. 19-24.
CRUCIANI, M. et al. Platelet-rich plasma for the treatment of alopecia: a systematic review and meta-analysis. Blood Transfus., 21, n. 1, Jan. 2023. 24-36.
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