IMMUNOGENICITY ASSOCIATED WITH BOTULINUM TOXIN TREATMENT
DOI:
https://doi.org/10.47820/recima21.v4i1.4227Keywords:
Botulinum Toxin, Immunogenicity, ImmunoresistanceAbstract
Introduction: Skin aging is an inevitable and natural factor of all human beings. In order to achieve prevention of the signs of aging and improvement of self-esteem, such as smoothing wrinkles and expression lines, aesthetic treatments have been increasing, with treatments based on botulinum toxin being the most sought after worldwide, however, little is addressed about immune resistance and long-term effects. Objective: To discuss the effects of botulinum toxin treatment over the years and the causes of resistance and the "vaccine effect". Method: Literature review work, having as source of research articles published in national and international journals. Discussion: In addition to intrinsic aging, we have to consider the extrinsic, which is related to external factors and the lifestyle of the individual, several factors influence the immunogenicity of botulinum neurotoxins, such as: factors related to the product, the manufacturing process, the antigenic protein load and the presence of accessory proteins, the immune system has cumulative memory and studies show that the formation of antibodies in patients of aesthetic treatments is rare, and those who developed antibodies, received doses of the formulation above the indicated, with an interval of less than one month between injections or else suffered cross-reaction to other antibodies resulting from multiple tetanus vaccines, since the botulinum toxin protein has parts of its structure homologous to the structure produced by Clostridium tetani.
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Aoki KR. Botulinum toxin: a successful therapeutic protein.[Internet]Curr Med Chem. 2004;11(23):3085-92. [cited 2023 May 12] Available from:https://www.Eurekaselect.com/ article/7848.
Meunier FA, Herreros J, Schiavo G, Poulain B, Molgó J. Molecular mechanism of action of botulinal neurotoxins and the synaptic remodeling they induce in vivo at skeletal neuromuscular junction. [Internet] In: Massaro EJ. Handbook of neurotoxicology. Totowa: Human Press; 2002 Barbosa DBM, Brito A de S. A utilização da toxina botulínica tipo a para alcançar a estética facial. Revista Terra & Cultura: Cadernos de Ensino e Pesquisa [Internet]. 2020 Jul 3;36(70):75–86.[cited 2023 May 12] Available from: http://periodicos.unifil.br/ index.php/Revistateste/ article/view/1354.
Kumar R, Dhaliwal H, Kukreja R, Singh B. The Botulinum Toxin as a Therapeutic Agent: Molecular Structure and Mechanism of Action in Motor and Sensory Systems. Seminars in Neurology. [Internet] 2016 Feb 11;36 (01):010–9. [cited 2023 May 12] Available from: https://www.thiemeconnect.de/products/ejournals/abstract/10.1055/s-0035-1571215.
Jankovic J. Botulinum toxin: State of the art. Movement Disorders. [Internet] 2017 Jun 22; 32(8):1131–8 [cited 2023 May 12] Available from: https://movementdisorders.onlinelibrary. wiley.com/doi/10.1002/mds.27072.
Lacordia MHFA, Januário FS-M, Pereira JCC. Estrabismo após toxina botulínica para fins estéticos. [Internet]. Rev brasoftalmol 2011 May; 70(3): 179–81.[cited 2023 May 12] Available from:https://doi.org/10.1590/S0034-72802011000300009.
Caroline Dos Reis L, Uchôas Luz D, Alves Da Silva A, Flaviana R, Fernandes, Bacelar De Assis I.Desvendando o uso da toxina botulínica na estética e em enfermidades/discovering the use of botulinic toxin in aesthetics and in diseases[Internet]. 2020 [cited 2023 May 12] Available from: https:// encurtador.com.br/TYZ48.
Poli MA, Lebeda FJ. An overview of clostridial neurotoxins.[Interner] In: Massaro EJ. Handbook of neurotoxicology. Totowa: Human Press; 2002. p. 293-30 [cited 2023May 12] Available from: https://link.springer.com/chapter/ 10.1007/978-1-59259-132-9_16.
Bernard Poulain, Michel R. Popoff, Jordi Molgó. How do the Botulinum Neurotoxins block neurotransmitter release: from botulism to the molecular mechanism of action. The Botulinum Journal, 2008, 1 (1), pp.14-87. [cited 2023 May 12] Available from: ⟨10.1504/TBJ.2008.018951⟩. ⟨hal-00303601⟩.
Turton K, Chaddock JA, Acharya KRavi. Botulinum and tetanus neurotoxins: structure, function and therapeutic utility. [Internet] Trends in Biochemical Sciences. 2002 Nov;27(11):552–8. [cited 2023 May 12] Available from: https://www.sciencedirect.com/ science/article/abs/pii/S0968000402021771.
Hicks RP, Hartell MG, Nichols DA, Bhattacharjee AK, van Hamont JE, Skillman DR. The medicinal chemistry of botulinum, ricin and anthrax toxins.[Internet] Curr Med Chem. 2005;12(6):667-90[cited 2023 May 12] Available from: https://pubmed.ncbi.nlm.nih.gov/ 15790305/. p 305-47 [cited 2023 May 12] Available from: https://hal.science/hal-00194091/.
Paiva A, Meunier FA, Molgó J, Aoki KR, Dolly JO. Functional repair of motor endplates after botulinum neurotoxin type A poisoning: biphasic switch of synaptic activity between nerve sprouts and their parent terminals.Proc Natl Acad Sci [Internet] USA. 1999;96(6):3200-5 [cited 2023 May 12] Available from: https:// www.ncbi.nlm.nih.gov/pmc/articles/PMC15919/.
FUJITA, R. L. R.; HURTADO, C. C. N., Aspectos relevantes do uso da toxina botulínica no tratamento estético e seus diversos mecanismos de ação. Rev. Saber Científico Internet] v. 8, n. 1, p.120–133, 2019, Porto Velho. [cited 2023 May 12] Available from: https:// revista.saolucas.edu.br/index.php /resc/article/ view/ 1069/pdf>. Acesso em: 20 de março de 2022.
SPOSITO, M. M. M., Toxina Botulínica do Tipo A: mecanismo de ação. [Internet] Rev. Acta Fisiátr, v.16, n.1, p. 25-37, 2009, São Paulo.[cited 2023 May 12] Available from: https://www.revistas.usp.br/actafisiatrica/ article/view/103037/ 101317 > .
Gart Michael, Gutowski Karol. Overview of Botulinum Toxins for Aesthetic Uses. Clinics in Plastic Surgery [Internet]. 2016 May 04 43(3):459-71.[cited 2023 Apr 11]; Available from: https://pubmed.ncbi.nlm.nih.gov/27363760/.
Archana M S. Toxin yet not toxic: Botulinum toxin in dentistry. The Saudi dental journal [Internet]. 2016 Jan 01 [cited 2023 Apr 4];28:63-9. DOI doi:10.1016/j.sdentj.2015.08.002 .Available:from:https://pubmed.ncbi.nlm.nih.gov/27486290/.
Naumann, M., et al. (2010). Meta-analysis of neutralizing antibody conversion with onabotulinumtoxinA (BOTOX®) across multiple indications. [Internet] Movement disorders: official journal of the Movement Disorder Society, 25(13), 2211–2218. [cited 2023 May 12] Available from: https://doi. org/10.1002/mds.23254.
Atassi MZ, Dolimbek BZ, Jankovic J, Steward LE, Aoki KR. Regions of botulinum neurotoxin A light chain recognized by human anti-toxin antibodies from cervical dystonia patients immunoresistant to toxin treatment. [Internet] Immunobiology. 2011 Jul; 216 (7):782–92. [cited 2023 May 12]. Available from: https://pubmed.ncbi.nlm.nih.gov/21281977/.
Baizabal-Carvallo José,Feld Jordan &Jankovic Joseph. Flu-like symptoms and associated immunological response following therapy with botulinum toxins. Neurotoxicity research [Internet]. 2013 May 16 2013(24):298-306. [cited 2023 Apr 4]; Available from: https://pubmed. ncbi.nlm.nih.gov/23677449/.
Wanitphakdeedecha R, Kantaviro W, Suphatsathienkul P, Tantrapornpong P, Yan C, Apinumtham C, et al. Association Between Secondary Botulinum Toxin A Treatment Failure in Cosmetic Indication and Anti-Complexing Protein Antibody Production. [Internet] Dermatology and Therapy. 2020 May 22;10(4):707–20.[cited 2023 May 12] Available from: https://pubmed.ncbi.nlm.nih.gov/32445175/
Park JY, Sunga O, Wanitphakdeedecha R, Frevert J. Neurotoxin Impurities. [Internet] Plastic and Reconstructive Surgery - Global Open. 2020 Jan ;8(1) :e2627 [cited 2023 May 12] Available from: https://pubmed.ncbi.nlm. nih.gov/32095419/.
Naumann Markus, et al. Immunogenicity of botulinum toxins. Journal of neural transmission [Internet]. 2012 Sep 25 [cited 2023 Apr 4];120(2):275-90. DOI 10.1007/s00702-012-0893-9. Available from: https://pubmed.ncbi.nlm. nih.gov/ 23008029/.
Hanna PA, Jankovic J, Vincent A. Comparison of mouse bioassay and immunoprecipitation assay for botulinum toxin antibodies. [Internet] Journal of Neurology, Neurosurgery & Psychiatry. 1999 May 1;66(5):612–6. [cited 2023 May 12] Available from: https://pubmed. ncbi.nlm.nih.gov/10209172/
Brin MF, Comella CL, Jankovic J, Lai F, Naumann M. Long-term treatment with botulinum toxin type A in cervical dystonia has low immunogenicity by mouse protection assay.[Internet] Movement Disorders. 2008 Jul 30;23 (10):1353–60. [cited 2023 May 12]. Available from: https://movementdisorders .onlinelibrary.wiley.com/ doi/ 10.1002/mds.22157.
Benecke Reiner. Clinical relevance of botulinum toxin immunogenicity. BioDrugs [Internet]. 2012 Apr 01 [cited 2023 Apr 4];26:e1-e9. DOI 10.2165/11599840-000000000-00000. Available from: https://pubmed.ncbi. nlm.nih.gov/22385408/.
Aoki K. Botulinum Toxin: A Successful Therapeutic Protein.[Internet] Current Medicinal Chemistry. 2004 Dec 1;11(23):3085–92. [cited on 2023 May 12] Available from: htps:// www.eurekaselect.com/article/7848.
Eduarda Pautz CAMPOS, Vicente C. Toxina botulínica tipo A: Ações farmacológicas e uso na estética facial: Pharmacological actions and use in facial aesthetics. Revista sáude Multidisciplinar[Internet].2021;9(1).[cited 2023 May 12] Available from: http://revistas.famp. edu.br/revistasaudemulti disciplinar/article/view/167.
Dressler D. Clinical presentation and management of antibody-induced failure of botulinum toxin therapy. [Internet] Movement Disorders. 2004;19(S8):S92–100. [cited 2023 May 12] Available from:https:// pubmed.ncbi.nlm.nih.gov/ 15027060/.
Bellows S, Jankovic J. Immunogenicity Associated with Botulinum Toxin Treatment.[Internet] Toxins. 2019 Aug 26;11(9):491. [cited 2023 May 12] Available from: https:// www.ncbi.nlm.nih .gov/pmc/articles/PMC6784164/.
Flynn TC.. Advances in the use of botulinum neurotoxins in facial esthetics. Journal of cosmetic dermatology [Internet]. 2012 Mar 11 [cited 2023 Apr 4];11:42–50. DOI https://doi.org/10.1111/j.1473-2165.2011.00593.x. Available from https://pubmed.ncbi .nlm.nih.gov/22360334/.
Stengel G, Bee EK. Antibody-induced secondary treatment failure in a patient treated with botulinum toxin type A for glabellar frown lines. Clinical interventions in aging [Internet]. 2011 Nov 09 [cited 2023 Apr 4];6:281–284. DOI https:// doi.org/10.2147/CIA.S18997.Available from: https://pubmed.ncbI.nlm.nih.gov/ 22162643/.
Silva VCM. O rejuvenescimento facial na Biomedicina Estética [Internet]. Universidade Federal de Pernambuco 2022 [cited 2023 May 13]. Available from: https:// repositorio.ufpe. br/handle/123456789/45422.
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