MOLECULAR MECHANISMS OF NEURONAL DEGENERATION IN PARKINSON'S DISEASE: A BIBLIOGRAPHICAL REVIEW
DOI:
https://doi.org/10.47820/recima21.v5i1.4810Keywords:
Parkinson's Disease, Nerve Degeneration, Signs and Symptoms, TherapeuticsAbstract
Introduction: Parkinson's disease (PD) is one of the most prevalent neurodegenerative conditions worldwide and is characterized by progressive degeneration of nerve cells, especially in the region of the brain known as the substantia nigra. This progressive, chronically debilitating disorder transcends its clinical manifestations, permeating the physical, cognitive and emotional spheres of those who experience its daily challenges. Methodology: This is a bibliographical review, using articles present in the following databases: PubMed, Scopus and SciELO. Original articles and systematic reviews in English and Portuguese published between 2020 and 2024 were included, which addressed Molecular Mechanisms of Neuronal Degeneration in PD. After analysis, 19 articles were selected to prepare this bibliographic review. Results and Discussion: From this review, the main molecular mechanisms associated with PD were presented: Alpha-synuclein Accumulation, Mitochondrial Dysfunctions, Oxidative Stress and Neuroimmune Inflammation. Conclusion: It is evident that PD is a complex condition, characterized by an intricate interconnection between molecular mechanisms and clinical manifestations.
Downloads
References
AHMAD, Mir Hilal et al. Neurobiology of depression in Parkinson’s disease: Insights into epidemiology, molecular mechanisms and treatment strategies. Ageing research reviews, p. 101840, 2023. DOI: https://doi.org/10.1016/j.arr.2022.101840
ARMSTRONG, Melissa J.; OKUN, Michael S. Diagnosis and treatment of Parkinson disease: a review. Jama, v. 323, n. 6, p. 548-560, 2020. DOI: https://doi.org/10.1001/jama.2019.22360
BORSCHE, Max et al. Mitochondria and Parkinson’s disease: clinical, molecular, and translational aspects. Journal of Parkinson's disease, v. 11, n. 1, p. 45-60, 2021. DOI: https://doi.org/10.3233/JPD-201981
CHEN, Rong et al. “α-Synuclein in Parkinson's disease and advances in detection.” Clinica chimica acta. international journal of clinical chemistry, v. 529, p. 76-86, 2022. DOI: https://doi.org/10.1016/j.cca.2022.02.006
CHURCH, Frank C. Treatment options for motor and non-motor symptoms of Parkinson’s disease. Biomolecules, v. 11, n. 4, p. 612, 2021. DOI: https://doi.org/10.3390/biom11040612
DAY, Jacob Oliver; MULLIN, Stephen. The genetics of Parkinson’s disease and implications for clinical practice. Genes, v. 12, n. 7, p. 1006, 2021. DOI: https://doi.org/10.3390/genes12071006
HALLI-TIERNEY, Anne D.; LUKER, Jacquelynn; CARROLL, Dana G. Parkinson disease. American family physician, v. 102, n. 11, p. 679-691, 2020.
KUMAR, Shivam; GOYAL, Lav; SINGH, Shamsher. Tremor and rigidity in patients with Parkinson’s disease: Emphasis on epidemiology, pathophysiology and contributing factors. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders), v. 21, n. 7, p. 596-609, 2022. DOI: https://doi.org/10.2174/1871527320666211006142100
MAGALHÃES, Francisco et al. Teorias causais, sintomas motores, sintomas não-motores, diagnóstico e tratamento da Doença de Parkinson: uma revisão bibliográfica. Research, Society and Development, v. 11, n. 7, p. e10811729762-e10811729762, 2022. DOI: https://doi.org/10.33448/rsd-v11i7.29762
PAJARES, Marta et al. Inflammation in Parkinson’s disease: mechanisms and therapeutic implications. Cells, v. 9, n. 7, p. 1687, 2020. DOI: https://doi.org/10.3390/cells9071687
RAJAN, Suraj; KAAS, Bonnie. Parkinson's disease: risk factor modification and prevention. In: Seminars in neurology. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USA: Thieme Medical Publishers, 2022. p. 626-638. DOI: https://doi.org/10.1055/s-0042-1758780
SIMON, David K.; TANNER, Caroline M.; BRUNDIN, Patrik. Parkinson disease epidemiology, pathology, genetics, and pathophysiology. Clinics in geriatric medicine, v. 36, n. 1, p. 1-12, 2020. DOI: https://doi.org/10.1016/j.cger.2019.08.002
SINGER, Carlos; REICH, Stephen G. Parkinson Disease. Clinics in geriatric medicine, v. 36, n. 1, p. xiii-xiv, 2020. DOI: https://doi.org/10.1016/j.cger.2019.10.001
STANDAERT, David G. et al. Disease mechanisms as subtypes: Inflammation in Parkinson disease and related disorders. In: Handbook of Clinical Neurology. [S. l.]: Elsevier, 2023. p. 95-106. DOI: https://doi.org/10.1016/B978-0-323-85555-6.00011-4
TANSEY, Malú Gámez et al. Inflammation and immune dysfunction in Parkinson disease. Nature Reviews Immunology, v. 22, n. 11, p. 657-673, 2022. DOI: https://doi.org/10.1038/s41577-022-00684-6
TROISI, Jacopo et al. Metabolomics in Parkinson's disease. Advances in clinical chemistry, v. 104, p. 107-149, 2021. DOI: https://doi.org/10.1016/bs.acc.2020.09.003
VIJIARATNAM, Nirosen et al. Progress towards therapies for disease modification in Parkinson's disease. The Lancet Neurology, v. 20, n. 7, p. 559-572, 2021. DOI: https://doi.org/10.1016/S1474-4422(21)00061-2
WALLER, Sophie et al. The initial diagnosis and management of Parkinson's disease. Australian Journal of General Practice, v. 50, n. 11, p. 793-890, 2021. DOI: https://doi.org/10.31128/AJGP-07-21-6087
YASUHARA, Takao. Neurobiology research in parkinson’s disease. International journal of molecular sciences, v. 21, n. 3, p. 793, 2020. DOI: https://doi.org/10.3390/ijms21030793
Downloads
Published
License
Copyright (c) 2024 RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218
This work is licensed under a Creative Commons Attribution 4.0 International License.
Os direitos autorais dos artigos/resenhas/TCCs publicados pertecem à revista RECIMA21, e seguem o padrão Creative Commons (CC BY 4.0), permitindo a cópia ou reprodução, desde que cite a fonte e respeite os direitos dos autores e contenham menção aos mesmos nos créditos. Toda e qualquer obra publicada na revista, seu conteúdo é de responsabilidade dos autores, cabendo a RECIMA21 apenas ser o veículo de divulgação, seguindo os padrões nacionais e internacionais de publicação.
