SEPSIS: AN OVERVIEW OF CAUSES, SYMPTOMS AND CURRENT TREATMENTS - A LITERATURE REVIEW
DOI:
https://doi.org/10.47820/recima21.v5i3.4973Keywords:
Sepsis. Systemic inflammatory response syndrome. Etiology. Diagnosis and treatment.Abstract
Introduction: Sepsis is a severe clinical syndrome triggered by a dysregulated systemic inflammatory response of the body to an infection. Its complexity lies in its clinical variability and the need for rapid intervention to improve patient outcomes. Objective: This study aims to review recent advances in the understanding of sepsis, including its pathophysiology, early diagnosis and treatment, highlighting challenges and emerging therapeutic strategies. Methods: A literature review was conducted through a search of electronic databases, selecting relevant studies published in the last 15 years that have contributed to the understanding of sepsis. Results and Discussion: Challenges in the identification and treatment of sepsis include clinical heterogeneity, antimicrobial resistance and variability in response to treatment. Recent advances, such as early biomarkers and adjuvant therapies, offer hope for a more effective approach. Conclusion: Despite persistent challenges, advances in the understanding and management of sepsis provide opportunities to improve patient outcomes. Interdisciplinary collaboration and ongoing research are key to addressing this global challenge and reducing the morbidity and mortality associated with sepsis.
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References
EVANS, Laura et al. Executive summary: surviving sepsis campaign: international guidelines for the management of sepsis and septic shock 2021. Critical care medicine, v. 49, n. 11, p. 1974-1982, 2021.
FLEISCHMANN-STRUZEK, Carolin et al. The global burden of paediatric and neonatal sepsis: a systematic review. The Lancet Respiratory Medicine, v. 6, n. 3, p. 223-230, 2018. DOI: https://doi.org/10.1016/S2213-2600(18)30063-8
MARTÍN-RAMÍREZ, Jair Francisco et al. Sepsis. Medicina interna de México, v. 30, n. 2, p. 159-175, 2014.
PAN, Shangwen et al. Sepsis-induced brain dysfunction: pathogenesis, diagnosis, and treatment. Oxidative Medicine and Cellular Longevity, v. 2022, 2022. DOI: https://doi.org/10.1155/2022/1328729
RANIERI, V. Marco et al. Drotrecogin alfa (activated) in adults with septic shock. New England Journal of Medicine, v. 366, n. 22, p. 2055-2064, 2012. DOI: https://doi.org/10.1056/NEJMoa1202290
RHEE, Chanu et al. Incidence and trends of sepsis in US hospitals using clinical vs claims data, 2009-2014. Jama, v. 318, n. 13, p. 1241-1249, 2017. DOI: https://doi.org/10.1001/jama.2017.13836
RHODES, Andrew et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive care medicine, v. 43, p. 304-377, 2017.
RUAN, Qiurong et al. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive care medicine, v. 46, n. 5, p. 846-848, 2020. DOI: https://doi.org/10.1007/s00134-020-05991-x
RUDD, Kristina E. et al. Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study. The Lancet, v. 395, n. 10219, p. 200-211, 2020.
SCHUETZ, Philipp et al. Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections. Evidence‐Based Child Health: A Cochrane Review Journal, v. 8, n. 4, p. 1297-1371, 2013. DOI: https://doi.org/10.1002/ebch.1927
SEYMOUR, Christopher W. et al. Assessment of clinical criteria for sepsis: for the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). Jama, v. 315, n. 8, p. 762-774, 2016. DOI: https://doi.org/10.1001/jama.2016.0288
SEYMOUR, Christopher W. et al. Time to treatment and mortality during mandated emergency care for sepsis. New England Journal of Medicine, v. 376, n. 23, p. 2235-2244, 2017. DOI: https://doi.org/10.1056/NEJMoa1703058
SEYMOUR, Christopher W.; ROSENGART, Matthew R. Septic shock: advances in diagnosis and treatment. Jama, v. 314, n. 7, p. 708-717, 2015. DOI: https://doi.org/10.1001/jama.2015.7885
SHAPIRO, Nathan I. et al. A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis. Critical care medicine, v. 37, n. 1, p. 96-104, 2009. DOI: https://doi.org/10.1097/CCM.0b013e318192fd9d
SINGER, Mervyn et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). Jama, v. 315, n. 8, p. 801-810, 2016. DOI: https://doi.org/10.1001/jama.2016.0287
VENET, Fabienne; MONNERET, Guillaume. Advances in the understanding and treatment of sepsis-induced immunosuppression. Nature Reviews Nephrology, v. 14, n. 2, p. 121-137, 2018. DOI: https://doi.org/10.1038/nrneph.2017.165
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