VASCULAR DEMENTIA: EXPLORING MECHANISMS, DIAGNOSIS, AND INTERVENTIONS - A LITERATURE REVIEW
DOI:
https://doi.org/10.47820/recima21.v5i3.4981Keywords:
Vascular dementia; Pathophysiology; Diagnosis; Therapeutic interventions; Clinical challenges.Abstract
Introduction: Vascular dementia, secondary to vascular brain lesions, is the second most common form of dementia. With an ageing population and an increase in vascular diseases, its burden on health systems is growing. This review addresses advances in understanding the mechanisms, diagnosis and management of vascular dementia. Objective: To explore the mechanisms underlying vascular dementia, examine advanced diagnostic methods and clinical challenges, discuss therapeutic interventions and management strategies, and highlight future perspectives and research challenges. Methods: A literature review was conducted, including original studies and reviews published without time limit. Inclusion and exclusion criteria were applied, and the search was carried out in various electronic databases. Discussion: Advances in understanding pathophysiology, vascular risk factors and their impact, and advanced diagnostic methods were highlighted. Therapeutic interventions, management strategies and palliative care were discussed. Conclusion: Vascular dementia is a global health challenge, requiring an integrated and individualized approach. Future research should target more specific therapies, while a multidisciplinary approach is crucial. This review summarizes recent advances and highlights the continued importance of research and clinical practice in vascular dementia.
Downloads
References
DE LEEUW, F. E.; VAN GIJN, J. Vascular dementia. Practical Neurology, v. 3, n. 2, p. 86, 2003. DOI: https://doi.org/10.1046/j.1474-7766.2003.04132.x
DURON, E.; HANON, Olivier. Vascular risk factors, cognitive decline, and dementia. Vascular health and risk management, v. 4, n. 2, p. 363-381, 2008. DOI: https://doi.org/10.2147/VHRM.S1839
GORELICK, Philip B.; COUNTS, Scott E.; NYENHUIS, David. Vascular cognitive impairment and dementia. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, v. 1862, n. 5, p. 860-868, 2016. DOI: https://doi.org/10.1016/j.bbadis.2015.12.015
IADECOLA, Costantino. The pathobiology of vascular dementia. Neuron, v. 80, n. 4, p. 844-866, 2013. DOI: https://doi.org/10.1016/j.neuron.2013.10.008
KHAN, Ayesha et al. Update on vascular dementia. Journal of geriatric psychiatry and neurology, v. 29, n. 5, p. 281-301, 2016. DOI: https://doi.org/10.1177/0891988716654987
KORCZYN, Amos D.; VAKHAPOVA, Veronika; GRINBERG, Lea T. Vascular dementia. Journal of the neurological sciences, v. 322, n. 1-2, p. 2-10, 2012. DOI: https://doi.org/10.1016/j.jns.2012.03.027
LEE, Ae Young. Vascular dementia. Chonnam medical journal, v. 47, n. 2, p. 66-71, 2011. DOI: https://doi.org/10.4068/cmj.2011.47.2.66
O'BRIEN, John; THOMAS, Alan. Vascular dementia. The Lancet, v. 386, n. 10004, p. 1698-1706, 2015. DOI: https://doi.org/10.1016/S0140-6736(15)00463-8
RAMOS, Alberto R.; DIB, Salim I.; WRIGHT, Clinton B. Vascular dementia. Current translational geriatrics and experimental gerontology reports, v. 2, p. 188-195, 2013. DOI: https://doi.org/10.1007/s13670-013-0054-5
RÖNNEMAA, Elina et al. Vascular risk factors and dementia: 40-year follow-up of a population-based cohort. Dementia and geriatric cognitive disorders, v. 31, n. 6, p. 460-466, 2011. DOI: https://doi.org/10.1159/000330020
SAHATHEVAN, Ramesh; BRODTMANN, Amy; DONNAN, Geoffrey A. Dementia, stroke, and vascular risk factors; a review. International Journal of Stroke, v. 7, n. 1, p. 61-73, 2012. DOI: https://doi.org/10.1111/j.1747-4949.2011.00731.x
VAN DER FLIER, Wiesje M. et al. Vascular cognitive impairment. Nature Reviews Disease Primers, v. 4, n. 1, p. 1-16, 2018. DOI: https://doi.org/10.1038/nrdp.2018.3
VENKAT, Poornima; CHOPP, Michael; CHEN, Jieli. Models and mechanisms of vascular dementia. Experimental neurology, v. 272, p. 97-108, 2015. DOI: https://doi.org/10.1016/j.expneurol.2015.05.006
VISWANATHAN, Anand; ROCCA, Walter A.; TZOURIO, Christophe. Vascular risk factors and dementia: how to move forward?. Neurology, v. 72, n. 4, p. 368-374, 2009. DOI: https://doi.org/10.1212/01.wnl.0000341271.90478.8e
WIESMANN, Maximilian; KILIAAN, Amanda J.; CLAASSEN, Jurgen AHR. Vascular aspects of cognitive impairment and dementia. Journal of Cerebral Blood Flow & Metabolism, v. 33, n. 11, p. 1696-1706, 2013. DOI: https://doi.org/10.1038/jcbfm.2013.159
Downloads
Published
License
Copyright (c) 2024 RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218
This work is licensed under a Creative Commons Attribution 4.0 International License.
Os direitos autorais dos artigos/resenhas/TCCs publicados pertecem à revista RECIMA21, e seguem o padrão Creative Commons (CC BY 4.0), permitindo a cópia ou reprodução, desde que cite a fonte e respeite os direitos dos autores e contenham menção aos mesmos nos créditos. Toda e qualquer obra publicada na revista, seu conteúdo é de responsabilidade dos autores, cabendo a RECIMA21 apenas ser o veículo de divulgação, seguindo os padrões nacionais e internacionais de publicação.
