USE OF CANNABIDIOL IN SCIATIC COMPRESSION NEUROPATHY: EXPERIMENTAL STUDY
DOI:
https://doi.org/10.47820/recima21.v5i1.5259Keywords:
Cannabidiol, Sciatic Neuropathy, Wistar RatsAbstract
Introduction: Peripheral neuropathy comprises a wide spectrum of syndromes, characterized by injuries to one or more peripheral nerves, and may be related to metabolic, degenerative, infectious diseases and physical trauma. The management of symptoms remains a major challenge, considering that in many situations, the adverse effects of drugs outweigh their advantages, impacting the quality of life of patients. Aims: To evaluate the effectiveness of cannabidiol in sensorimotor functional recovery resulting from crushing the sciatic nerve. Methods: After CEUA approval, 15 female Wistar rats (Rattus norvegicus), with a mean age of three months and weight of 250 ± 20 g, from the Science Facility were used. Animal from UNIFESO. The animals were divided into: Control Group (CG, n = 5); no surgical procedure; Trauma Group (TGR, n = 5); crushing of the sciatic nerve of the left abdominal limb, followed by surgical synthesis; Cannabidiol Group (CDBG, n = 5); procedure like the previous one, followed by oral administration of 60 mg/kg/day of cannabidiol for seven days. All groups were submitted to locomotion tests, with assessment of the degree of lameness by the modified Muzzi Score, and histological analysis of the sciatic nerve. Results: When comparing the GCDB with the GTR, the lameness score was significantly higher (30.43%) in the treated animals (P < 0.05). Histological findings also demonstrated a greater precocity of the regenerative process in GCBD. Conclusions: The results were promising, considering the pathophysiological complexity of peripheral neuropathy and the need for more robust complementary studies with greater analytical rigor.
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