DEPRESSION IN THE ELDERLY: CONTRIBUTING FACTORS AND THERAPEUTIC INTERVENTIONS - A LITERATURE REVIEW

Authors

DOI:

https://doi.org/10.47820/recima21.v5i6.5383

Keywords:

Depression in the elderly. Contributing factors. Therapeutic interventions. Prevalence. Treatment.

Abstract

Depression in the elderly is a significant public health problem, affecting 10% to 15% of this population globally. Biological, psychological, and social factors, including neurochemical changes, significant losses, and social isolation, aggravated by chronic comorbidities, contribute to this picture. Objective: This article aims to conduct a literature review on the factors contributing to depression in the elderly and the most effective therapeutic interventions. Methods: A systematic literature review was conducted in databases such as PubMed, Web of Science, Scopus, and Google Scholar, covering publications from 2004 to 2024. Inclusion criteria included original studies and reviews on depression in the elderly, in English, Portuguese or Spanish. Case reports, editorials, and studies focused on other medical conditions were excluded. Results and Discussion: The prevalence of depression in the elderly is influenced by socioeconomic conditions, social support, and physical health. Biological factors include neurochemical and hormonal changes, while psychological factors encompass significant losses and physical and cognitive decline. Social isolation is a critical factor. Chronic comorbidities aggravate the risk of depression and complicate treatment. Pharmacological interventions, such as antidepressants, are effective but require careful management. Psychosocial therapies, such as cognitive behavioral therapy and reminiscence therapy, are essential, as are social support programs and community activities. Conclusion: Depression in the elderly requires a multifaceted and integrated approach, combining pharmacological and psychosocial treatments with social support. Public health policies should promote the mental health of the elderly, investing in social support programs and training of specialized professionals. 

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Author Biographies

  • Mateus Sousa Gonçalves

    Acadêmico de Medicina.

  • Yasmim Vilela Rodrigues

    Acadêmica de Medicina.

  • Nathália de Melo Carmanini

    Acadêmica de Medicina.

  • Adler Alencar dos Santos

    Acadêmico de Medicina.

  • Thaís De Oliveira Martins

    Acadêmica de Medicina.

References

AHMADPANAH, Mohammad et al. Detached mindfulness reduced both depression and anxiety in elderly women with major depressive disorders. Psychiatry research, v. 257, p. 87-94, 2017. DOI: https://doi.org/10.1016/j.psychres.2017.07.030

ALEXOPOULOS, George S. Mechanisms and treatment of late-life depression. Translational psychiatry, v. 9, n. 1, p. 188, 2019. DOI: https://doi.org/10.1038/s41398-019-0514-6

ALMEIDA, Osvaldo P. et al. Depression, antidepressants and the risk of cardiovascular events and death in older men. Maturitas, v. 128, p. 4-9, 2019. DOI: https://doi.org/10.1016/j.maturitas.2019.06.009

ALMEIDA, Osvaldo P. Prevention of depression in older age. Maturitas, v. 79, n. 2, p. 136-141, 2014. DOI: https://doi.org/10.1016/j.maturitas.2014.03.005

ASSIL, S. M.; ZEIDAN, Z. A. Prevalence of depression and associated factors among elderly Sudanese: a household survey in Khartoum State. EMHJ-Eastern Mediterranean Health Journal, v. 19, n. 5, p. 435-440, 2013. DOI: https://doi.org/10.26719/2013.19.5.435

CACIOPPO, John T.; HAWKLEY, Louise C.; THISTED, Ronald A. Perceived social isolation makes me sad: 5-year cross-lagged analyses of loneliness and depressive symptomatology in the Chicago Health, Aging, and Social Relations Study. Psychology and aging, v. 25, n. 2, p. 453, 2010. DOI: https://doi.org/10.1037/a0017216

CASEY, David A. Depression in older adults: a treatable medical condition. Primary Care: Clinics in Office Practice, v. 44, n. 3, p. 499-510, 2017. DOI: https://doi.org/10.1016/j.pop.2017.04.007

CORRÊA, Mariana Lima et al. Depression in the elderly of a rural region in Southern Brazil. Ciencia & Saude Coletiva, v. 25, p. 2083-2092, 2020. DOI: https://doi.org/10.1590/1413-81232020256.18392018

DEPRESSION, W. H. O. Other common mental disorders: global health estimates. Geneva: World Health Organization, 2017.

DINIZ, Breno S. et al. Late-life depression and risk of vascular dementia and Alzheimer's disease: systematic review and meta-analysis of community-based cohort studies. The British Journal of Psychiatry, v. 202, n. 5, p. 329-335, 2013. DOI: https://doi.org/10.1192/bjp.bp.112.118307

FIGEE, Martijn et al. Deep brain stimulation induces striatal dopamine release in obsessive-compulsive disorder. Biological psychiatry, v. 75, n. 8, p. 647-652, 2014. DOI: https://doi.org/10.1016/j.biopsych.2013.06.021

GABRYELEWICZ, T. et al. Prevalence of major and minor depression in elderly persons with mild cognitive impairment—MADRS factor analysis. International journal of geriatric psychiatry, v. 19, n. 12, p. 1168-1172, 2004. DOI: https://doi.org/10.1002/gps.1235

HELVIK, Anne-Sofie et al. A psychometric evaluation of the Hospital Anxiety and Depression Scale for the medically hospitalized elderly. Nordic journal of psychiatry, v. 65, n. 5, p. 338-344, 2011. DOI: https://doi.org/10.3109/08039488.2011.560684

JONGENELIS, Keith et al. Prevalence and risk indicators of depression in elderly nursing home patients: the AGED study. Journal of affective disorders, v. 83, n. 2-3, p. 135-142, 2004. DOI: https://doi.org/10.1016/j.jad.2004.06.001

KASTENSCHMIDT, Erin K.; KENNEDY, Gary J. Depression and anxiety in late life: diagnostic insights and therapeutic options. Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine, v. 78, n. 4, p. 527-545, 2011. DOI: https://doi.org/10.1002/msj.20266

KOPF, Daniel; HEWER, Walter. Prevention of depression in old age: individual and societal relevance. Zeitschrift fur Gerontologie und Geriatrie, v. 57, n. 3, p. 175-178, 2024. DOI: https://doi.org/10.1007/s00391-024-02306-3

KULLBERG, Marie-Louise et al. Parental bonding: Psychometric properties and association with lifetime depression and anxiety disorders. Psychological Assessment, v. 32, n. 8, p. 780, 2020. DOI: https://doi.org/10.1037/pas0000864

LEVIN, O. S.; VASENINA, E. E. Depression and cognitive decline in elderly: causes and consequences. Zhurnal Nevrologii i Psikhiatrii Imeni SS Korsakova, v. 119, n. 7, p. 87-94, 2019. DOI: https://doi.org/10.17116/jnevro201911907187

LOPRESTI, Adrian L. et al. Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study. Journal of affective disorders, v. 167, p. 368-375, 2014. DOI: https://doi.org/10.1016/j.jad.2014.06.001

LYNESS, Jeffrey M. et al. Outcomes of minor and subsyndromal depression among elderly patients in primary care settings. Annals of internal medicine, v. 144, n. 7, p. 496-504, 2006. DOI: https://doi.org/10.7326/0003-4819-144-7-200604040-00008

MAIER, Alexander et al. Risk factors and protective factors of depression in older people 65+. A systematic review. PloS one, v. 16, n. 5, p. e0251326, 2021. DOI: https://doi.org/10.1371/journal.pone.0251326

MERDJANOFF, Alexis A. et al. Housing transitions and recovery of older adults following Hurricane Sandy. The Journals of Gerontology: Series B, v. 74, n. 6, p. 1041-1052, 2019. DOI: https://doi.org/10.1093/geronb/gby126

PARK, Mijung; UNÜTZER, Jürgen. Geriatric depression in primary care. Psychiatric Clinics, v. 34, n. 2, p. 469-487, 2011. DOI: https://doi.org/10.1016/j.psc.2011.02.009

SALK, Rachel H.; HYDE, Janet S.; ABRAMSON, Lyn Y. Gender differences in depression in representative national samples: Meta-analyses of diagnoses and symptoms. Psychological bulletin, v. 143, n. 8, p. 783, 2017. DOI: https://doi.org/10.1037/bul0000102

SEIDLER, Zac E. et al. The role of masculinity in men's help-seeking for depression: a systematic review. Clinical psychology review, v. 49, p. 106-118, 2016. DOI: https://doi.org/10.1016/j.cpr.2016.09.002

SJÖBERG, Linnea et al. Prevalence of depression: Comparisons of different depression definitions in population-based samples of older adults. Journal of affective disorders, v. 221, p. 123-131, 2017. DOI: https://doi.org/10.1016/j.jad.2017.06.011

SUN, X. et al. Depressive costs: medical expenditures on depression and depressive symptoms among rural elderly in China. Public Health, v. 181, p. 141-150, 2020 DOI: https://doi.org/10.1016/j.puhe.2019.12.011

TAKEDA, Masatoshi; TANAKA, Toshihisa. Depression in the elderly. Geriatrics & gerontology international, v. 10, n. 4, p. 277-279, 2010. DOI: https://doi.org/10.1111/j.1447-0594.2010.00644.x

TAYLOR, Warren D. Depression in the elderly. New England journal of medicine, v. 371, n. 13, p. 1228-1236, 2014. DOI: https://doi.org/10.1056/NEJMcp1402180

TIONG, Wei Wei et al. Prevalence and risk factors of depression in the elderly nursing home residents in Singapore. Aging & mental health, v. 17, n. 6, p. 724-731, 2013. DOI: https://doi.org/10.1080/13607863.2013.775638

VINK, Dagmar; AARTSEN, Marja J.; SCHOEVERS, Robert A. Risk factors for anxiety and depression in the elderly: a review. Journal of affective disorders, v. 106, n. 1-2, p. 29-44, 2008. DOI: https://doi.org/10.1016/j.jad.2007.06.005

Published

17/06/2024

How to Cite

DEPRESSION IN THE ELDERLY: CONTRIBUTING FACTORS AND THERAPEUTIC INTERVENTIONS - A LITERATURE REVIEW. (2024). RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, 5(6), e565383. https://doi.org/10.47820/recima21.v5i6.5383