RELATIONSHIP BETWEEN SPHINGOMYELIN LEVELS AND PARKINSON'S DISEASE: EVIDENCE AND PERSPECTIVES
DOI:
https://doi.org/10.47820/recima21.v5i9.5632Keywords:
Neurodegenerative Diseases. Metabolism. Lipids.Abstract
Parkinson's disease (PD) is the second most common neurodegenerative disease (ND) after Alzheimer's disease (AD). Studies over two decades have revealed the association between PD and defects in lysosomal sphingolipid metabolism. Objectives: to identify if there are changes in sphingomyelin in Parkinson's disease. Materials and methods: This is an integrative review, in which the guiding question was “Are sphingomyelins altered in Parkinson's disease?”. The search for articles was carried out in PubMed and Google Scholar using the terms “sphingomyelin” and “parkinson's disease”, combined with the Boolean operator “AND”. Results and discussion: Sphingomyelin belongs to a class of lipids called sphingolipids. Disruption in the sphingomyelin signaling pathway is associated with several neurodegenerative disorders, including Parkinson's disease. Serum lipids were significantly altered between those with and without Parkinson's disease. Sphingomyelin is essential for the myelin sheath, impulse transmission, synaptic plasticity, neurotransmitter receptor localization, and integrity of the blood-brain barrier. Conclusion: we concluded in our study that sphingomyelin levels are reduced in Parkinson's disease.
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