EFFICACY AND SAFETY OF COLLAGEN BIOSTIMULATORS IN THE TREATMENT OF SKIN LAXITY: A LITERATURE REVIEW

Authors

DOI:

https://doi.org/10.47820/recima21.v5i11.5927

Keywords:

Aging, Collagen, Rejuvenation

Abstract

Skin aging is characterized by significant changes in the dermis and epidermis, resulting from intrinsic and extrinsic factors, with laxity being one of the main problems arising from the loss of collagen and elastin. In this context, collagen biostimulators emerge as an alternative for skin rejuvenation by stimulating the natural production of collagen by the body’s cells. Thus, the present study aimed to evaluate the safety and efficacy of biostimulators used in aesthetic treatments, emphasizing the different application techniques, combinations of agents, and their implications for tissue quality, patient satisfaction, and incidence of adverse effects. The methodology consisted of a literature review, selecting articles published in the last five years from the PubMed and Google Scholar databases. Analyzing 14 selected studies, promising results were identified, indicating a significant improvement in skin quality, facial volume, and contours, accompanied by high patient satisfaction. Biostimulators demonstrated the ability to stimulate collagen production, contributing to skin rejuvenation naturally. Furthermore, the review highlights the importance of personalizing treatments, considering the individual needs of patients, to maximize results and minimize possible adverse effects. Despite the positive data, there is a need for additional research to investigate the safety profile and long-term efficacy of biostimulators in aesthetic clinical practice, aiming to establish more robust guidelines for their use.

Downloads

Download data is not yet available.

Author Biographies

  • Antonella Pinheiro Pereira

    Discente do curso de Biomedicina – Universidade Nilton Lins.

  • Viviane Marinho dos Santos

    Docente do curso de Biomedicina – Universidade Nilton Lins.

References

ALVES, Gabriela Fernandes Ferro; SANTOS, Gabriela Cardoso Sousa; PAULIN, Liana Bonfim Misson. Bioestimulação de colágeno e volumização tecidual em região de glabela: uma revisão da literatura. Revista ICESP, [s. l.], v. 2, n. 2, 2023.

AMARAL, Virginia Marcia et al. An Innovative Treatment Using Calcium Hydroxyapatite for Non-Surgical Facial Rejuvenation: The Vectorial-Lift Technique. Aesthetic Plastic Surgery, [s. l.], 2024. DOI: https://doi.org/10.1007/s00266-024-04071-5

BERNARDO, Rachel Thacyana Rorato et al. Effect of poly‐L‐lactic acid and polydioxanone biostimulators on type I and III collagen biosynthesis. Skin Research and Technology, [s. l.], v. 30, n. 4, p. e13681, 2024. DOI: https://doi.org/10.1111/srt.13681

BRAVO, Bruna Souza Felix; CARVALHO, Raquel De Melo. Safety in immediate reconstitution of poly‐ L ‐lactic acid for facial biostimulation treatment. Journal of Cosmetic Dermatology, [s. l.], v. 20, n. 5, p. 1435–1438, 2021. DOI: https://doi.org/10.1111/jocd.13597

CHERNOFF, Greg. Combining topical dermal infused exosomes with injected calcium hydroxylapatite for enhanced tissue biostimulation. Journal of Cosmetic Dermatology, [s. l.], v. 22, n. S1, p. 15–27, 2023. DOI: https://doi.org/10.1111/jocd.15695

DANYSZ, Wojciech et al. Can Sodium Thiosulfate Act as a Reversal Agent for Calcium Hydroxylapatite Filler? Results of a Preclinical Study. Clinical, Cosmetic and Investigational Dermatology, [s. l.], v. 13, p. 1059–1073, 2020. DOI: https://doi.org/10.2147/CCID.S271760

FARIA, Gladstone; BOGGIO, Ricardo; BELLINI, Marcelo. Glutaeal remodelling protocol: Volumization with hyaluronic acid and collagen biostimulation with poly‐L‐lactic acid. Skin Health and Disease, [s. l.], v. 3, n. 4, p. e244, 2023. DOI: https://doi.org/10.1002/ski2.244

FIGUEREDO, Vinícius O. et al. Efficacy and Safety of 2 Injection Techniques for Hand Biostimulatory Treatment With Diluted Calcium Hydroxylapatite. Dermatologic Surgery, [s. l.], v. 46, n. 1, p. S54–S61, 2020. DOI: https://doi.org/10.1097/DSS.0000000000002334

IANHEZ, Mayra et al. Complications of collagen biostimulators in Brazil: Description of products, treatments, and evolution of 55 cases. Journal of Cosmetic Dermatology, [s. l.], v. 23, n. 9, p. 2829–2835, 2024. DOI: https://doi.org/10.1111/jocd.16343

MASSIDDA, Enrico. Starting Point for Protocols on the Use of Hyperdiluted Calcium Hydroxylapatite (Radiesse®) for Optimizing Age-Related Biostimulation and Rejuvenation of Face, Neck, Décolletage and Hands: A Case Series Report. Clinical, Cosmetic and Investigational Dermatology, [s. l.], v. 16, p. 3427–3439, 2023. DOI: https://doi.org/10.2147/CCID.S420068

MIRANDA, Clessya Rocha. Association of PDO threads and technologies—Facial treatment protocols. Journal of Cosmetic Dermatology, [s. l.], v. 22, n. 3, p. 804–809, 2023. DOI: https://doi.org/10.1111/jocd.15530

NECA, Cinthia Silva Moura et al. Uso do bioestimulador de colágeno corporal para tratamento da flacidez. Research, Society and Development, [s. l.], v. 11, n. 16, p. e600111637464, 2022. DOI: https://doi.org/10.33448/rsd-v11i16.37464

NOWAG, Bartosch et al. Biostimulating fillers and induction of inflammatory pathways: A preclinical investigation of macrophage response to calcium hydroxylapatite and poly‐L lactic acid. Journal of Cosmetic Dermatology, [s. l.], v. 23, n. 1, p. 99–106, 2024. DOI: https://doi.org/10.1111/jocd.15928

OLIVEIRA, Larissa Valverde de; FERREIRA, Larissa Gorayb. A ação do bioestimulador de colágeno no rejuvenescimento corporal da pele. Revista Científica UNILAGO, [s. l.], v. 1, n. 1, 2023.

PAPAIORDANOU, Francine et al. Colágeno e pele: da estrutura às evidências de sua suplementação oral. Surgical & Cosmetic Dermatology, [s. l.], v. 14, 2022. Disponível em: http://www.surgicalcosmetic.org.br/details/949/en-US/colageno-e-pele--da-estrutura-as-evidencias-de-sua-suplementacao-oral. Acesso em: 11 set. 2024. DOI: https://doi.org/10.5935/scd1984-8773.20221400110

SARUBI, Juliana et al. Targeted and Individualized Gluteal Poly-L-Lactic Acid Injection for Optimal Aesthetic Results in the Gluteal Region. The Journal of Clinical and Aesthetic Dermatology, [s. l.], v. 16, n. 6, p. 30–36, 2023.

SIGNORI, Roberta et al. Efficacy and Safety of Poly-l-Lactic Acid in Facial Aesthetics: A Systematic Review. Polymers, [s. l.], v. 16, n. 18, p. 2564, 2024. DOI: https://doi.org/10.3390/polym16182564

WILLIS, Kateryn Michelle Perez; GALVEZ, Rosario Ramirez. Granuloma after the Injection of Poly-D,L-Lactic Acid (PDLLA) Treated with Triamcinolone. Case Reports in Dermatological Medicine, [s. l.], v. 2024, p. 1–4, 2024. DOI: https://doi.org/10.1155/2024/6544506

WINK, Natália Ferrari; SCHNEIDER, Taiane. Bioestimuladores de colágeno E suas aplicações na estética: uma revisão bibliográfica. Revista REVIVA, [s. l.], v. 3, n. 2, 2024.

Published

16/11/2024

How to Cite

EFFICACY AND SAFETY OF COLLAGEN BIOSTIMULATORS IN THE TREATMENT OF SKIN LAXITY: A LITERATURE REVIEW. (2024). RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, 5(11), e5115927. https://doi.org/10.47820/recima21.v5i11.5927