PSORIASIS, ETIOLOGY AND ITS PSYCHOLOGICAL ASPECTS
DOI:
https://doi.org/10.47820/recima21.v5i1.5958Keywords:
Psoriasis. Autoimmune disease. Treatment. Pathophysiology. Quality of life. Psychological management.Abstract
Psoriasis, an autoimmune dermatological disease defined by the presence of eczema, scaly and reddish lesions on the skin. This condition considerably influences the quality of life of sufferers due to the psychological and physical impact. The etiology of psoriasis is heterogeneous, involving genetic predisposition, dysregulation of the immune system, and environmental factors. This disease is mediated by the immune system, where an atypical activation of T lymphocytes occurs. The exacerbated immune response leads to the release of pro-inflammatory cytokines such as IL-17, IFN-γ, IL-6, TNF-α and IL-8 that promote the increase of keratinocytes and skin inflammation. Dendritic cells and T lymphocytes play a crucial role in the maintenance of plaques, helping for a continuous inflammatory cycle. Psoriasis can severely impair quality of life, impacting social interaction and performance at work and studies. Therefore, psychological health management is essential for the overall treatment of psoriasis. These treatments for psoriasis can change according to the severity of the disease and include: systemic drug treatments, topical corticosteroids, light therapy, and complementary therapies.
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