PHAGE THERAPY: AN INNOVATIVE APPROACH TO TREATING INFECTIONS CAUSED BY RESISTANT BACTERIA
DOI:
https://doi.org/10.47820/recima21.v6i2.6264Keywords:
Bacteriophages, Phage Therapy, Bacterial Resistence, AntibioticsAbstract
Among the problems facing infectious diseases today, bacterial resistance to antibiotics is a significant threat to public health, especially in terms of treating infections. Thus, in an era of antibiotic resistance, bacteriophages have become a potential therapeutic product against infections. Bacteriophages are viruses that infect bacteria with high specificity and can also be designed, using genetic engineering, to exterminate antibiotic-resistant strains. At least 1 million people a year are affected by resistant infections in Brazil, the most worrying bacteria being Klebsiella pneumoniae, Escherichia coli and Acinetobacter baumanii. Phage therapy can be divided into two main approaches: personalized and non-personalized, with the former having better results. Phages proved to be well tolerated and safe, regardless of the route used. However, clinical trials still lack complete systematization of the methodology, and it is crucial to promote and invest in well-structured clinical trials to guarantee better results for patients
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