INFLUENCE OF INTESTINAL MICROBIOTA ON THE PREVALENCE OF DIABETES MELLITUS AT THE PROVINCIAL HOSPITAL OF BENGUELA FROM OCTOBER 2011 TO OCTOBER 2012
DOI:
https://doi.org/10.47820/recima21.v6i7.6556Keywords:
Intestinal microbiota. Diabetes Mellitus. Dysbiosis.Abstract
This study investigated the relationship between gut microbiota and the prevalence of Diabetes Mellitus (DM) in patients treated at the Provincial Hospital of Benguela, Angola, between October 2011 and October 2012. It is a retrospective and cross-sectional study that analyzed sociodemographic, clinical, and laboratory data from 6,446 patients, focusing on risk factors such as obesity, physical inactivity, and dietary habits. The results revealed a DM prevalence of 16.9%, with a higher incidence in women (52%) and in the age groups of 20-25 years (26.7%) and 40-45 years (21.6%). Obesity (BMI ≥ 30 kg/m²) was observed in 12% of patients, and 55% were sedentary. The literature review highlighted that gut dysbiosis is associated with the pathophysiological mechanisms of DM, such as systemic inflammation and insulin resistance, mediated by short-chain fatty acids (SCFAs). It was concluded that dysbiosis, exacerbated by inadequate diet and the use of antibiotics, can significantly influence the prevalence of DM. Strategies such as probiotics, prebiotics, and fecal microbiota transplantation have been suggested as adjuncts in disease control. The study reinforces the need for public policies and multidisciplinary interventions to promote healthy habits and awareness about intestinal microbiota.
Downloads
References
ANTÓNIO, R. L. B. Causas da recaída dos pacientes com diabetes mellitus tratados no Hospital Militar de Cabinda-Angola e a sua relação com as Políticas Públicas da Saúde. Rosária Lumbo Bueia António, v. 13, n. 2018, 2023.
BETTELHEIM, K. A. et al. "The origin of serotypes of Escherichia coli in babies after normal delivery". Journal of Hygiene, 2009.
CANI, P. D. et al. "Metabolic endotoxemia initiates obesity and insulin resistance". Diabetes, 2007. DOI: https://doi.org/10.2337/db06-1491
COPPA, G. V. et al. "Human milk oligosaccharides and their role in infant health". Journal of Pediatric Gastroenterology and Nutrition, 2004.
COSTA, A. F. et al. "Carga do diabetes mellitus tipo 2 no Brasil". Cadernos de Saúde Pública, v. 33, n. 2, e 00197915, 2017. DOI: https://doi.org/10.1590/0102-311x00197915
DE VADDER, F. et al. "Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits". Cell, 2014. DOI: https://doi.org/10.1016/j.cell.2013.12.016
DEHINGIA, M. et al. Gut bacterial diversity of the tribes of India and comparison with the worldwide data. Scientific Reports, v. 5, 18563, 2015. DOI: https://doi.org/10.1038/srep18563
DERRIEN, M. et al. Akkermansia muciniphila and its role in regulating host functions. Microbial Pathogenesis, v. 106, p. 171–181, 2017. DOI: https://doi.org/10.1016/j.micpath.2016.02.005
DÍAZ, O. D. Programa Nacional de Diabetes. Havana, Cuba: PND, 2000.
DiBAISE, J. K. et al. "Gut microbiota and its possible relationship with obesity". Mayo Clinic Proceedings, 2012.
FLOROWSKA, A. et al. Prebiotics as functional food ingredients preventing diet-related diseases. Food & Function, v. 7, p. 2147–2155, 2016. DOI: https://doi.org/10.1039/C5FO01459J
FRANCINO, M. P. "Antibiotics and the Human Gut Microbiome". Frontiers in Microbiology, 2016.
GARDNER, D.; SHOBACK, D. O que é a diabete/Controlar a diabetes: Material educacional de suporte ao ensino da Diabetes Mellitus. 9. ed. Lisboa, Portugal: McGraw Hill, 2011.
GUARIGUATA, L. et al. Atlas de la Diabetes, comité de la sexta edición. Madrid, Espanha: Merck and Co, Inc, 2013.
GUARNER, F.; MALAGELADA, J. R. "Gut flora in health and disease". The Lancet, v. 361, n. 9356, p. 512-519, 2003. DOI: https://doi.org/10.1016/S0140-6736(03)12489-0
KNIP, M.; SILJANDER, H. The role of the intestinal microbiota in type 1 diabetes mellitus. Nature Reviews Endocrinology, v. 12, p. 154–167, 2016. DOI: https://doi.org/10.1038/nrendo.2015.218
MACKIE, R. I. et al. "Developmental microbial ecology of the neonatal gastrointestinal tract". American Journal of Clinical Nutrition, 1999. DOI: https://doi.org/10.1093/ajcn/69.5.1035s
MARIETTA, E. V. et al. Low incidence of spontaneous type 1 diabetes in non-obese diabetic mice raised on gluten-free diets. PLoS ONE, v. 8, e78687, 2013. DOI: https://doi.org/10.1371/journal.pone.0078687
MARQUEZINE, G. F.; MANCINI, M. C. "Diabetes Mellitus: classificação e diagnóstico". Revista Brasileira de Medicina, v. 65, n. 1, p. 1-6, 2008.
MATSUDA, M. et al. "Gut microbiota and type 2 diabetes mellitus". Journal of Diabetes Investigation, 2015.
MINISTÉRIO DA SAÚDE. VIGITEL 2014: Vigilância de fatores de risco e proteção para doenças crônicas por inquérito telefônico. Brasília: Ministério da Saúde, 2015.
MUSSO, G. et al. Interactions between gut microbiota and host metabolism predisposing to obesity and diabetes. Annual Review of Medicine, v. 62, p. 361–380, 2011. DOI: https://doi.org/10.1146/annurev-med-012510-175505
OMS. Global status report on noncommunicable diseases. Genebra: World Health Organization, 2012.
OMS. Relatório sobre a prevalência de diabetes em Angola. [S. l.]: Organização Mundial da Saúde, 2011.
OPAS. Rastreamento e diagnóstico de diabetes mellitus gestacional no Brasil. [S. l.]: Organização Pan-Americana da Saúde, 2017.
PASCOAL, R. M. da C. Estudo da prevalência de casos de diabetes mellitus diagnosticados no laboratório de análises clínicas do Hospital Geral de Benguela outubro 2011- outubro 2012. [S. l.]: Hospital Geral de Benguela, 2020.
RAMPELLI, S. et al. Metagenome sequencing of the Hadza hunter-gatherer gut microbiota. Current Biology, v. 25, p. 1682–1693, 2015. DOI: https://doi.org/10.1016/j.cub.2015.04.055
RIBEIRO, A. L. et al. Diabetes mellitus. (Caderno de atenção básica nº6 Série A. Normas e Manuais Técnicos). Brasília: Ministério da Saúde, 2006.
ROUND, J. L.; MAZMANIAN, S. K. "The gut microbiota shapes intestinal immune responses". Nature Reviews Immunology, 2009. DOI: https://doi.org/10.1038/nri2515
SÁEZ-LARA, M. J. et al. "Effects of probiotics and synbiotics on obesity, insulin resistance syndrome, type 2 diabetes and non-alcoholic fatty liver disease". Journal of Functional Foods, 2015. DOI: https://doi.org/10.3390/ijms17060928
SARRETA, F. O. As políticas públicas de saúde. São Paulo: Unesp, 2009.
SAVAGEM, D. C. "Microbial ecology of the gastrointestinal tract". Annual Review of Microbiology, 1977. DOI: https://doi.org/10.1146/annurev.mi.31.100177.000543
SCHNORR, S. L. et al. Gut microbiome of the Hadza hunter-gatherers. Nature Communications, v. 5, 3654, 2014. DOI: https://doi.org/10.1038/ncomms4654
SENDER, R.; FUCHS, S.; MILO, R. "Revised estimates for the number of human and bacteria cells in the body". PLoS Biology, v. 14, n. 8, e1002533, 2016. DOI: https://doi.org/10.1371/journal.pbio.1002533
SINGH, R. K. et al. Influence of diet on the gut microbiome and implications for human health. Journal of Translational Medicine, v. 15, n. 73, 2017. DOI: https://doi.org/10.1186/s12967-017-1175-y
SINGHI, S. C.; KUMAR, S. "Probiotics in critically ill children". F1000Research, v. 5, p. 407, 2016. DOI: https://doi.org/10.12688/f1000research.7630.1
SOCIEDADE BRASILEIRA DE DIABETES. Diretrizes da Sociedade Brasileira de Diabetes 2015-2016. São Paulo: Sociedade Brasileira de Diabetes, 2016.
TIAN, Y. et al. Vitamin A deficiency alters host and gut microbial metabolism. Journal of Nutritional Biochemistry, v. 54, p. 28–34, 2017. DOI: https://doi.org/10.1016/j.jnutbio.2017.10.011
TOJO, R. et al. "Intestinal microbiota in health and disease: role of bifidobacteria in gut homeostasis". World Journal of Gastroenterology, 2014. DOI: https://doi.org/10.3748/wjg.v20.i41.15163
TURNBAUGH, P. J. et al. "An obesity-associated gut microbiome with increased capacity for energy harvest". Nature, 2006. DOI: https://doi.org/10.1038/nature05414
VALLADARES, R. et al. Lactobacillus johnsonii mitigates the development of type 1 diabetes in BB-DP rats. PLoS ONE, v. 5, e10507, 2010. DOI: https://doi.org/10.1371/journal.pone.0010507
VELLOSO, L. A. et al. TLR4 at the crossroads of nutrients, gut microbiota, and metabolic inflammation. Endocrine Reviews, v. 36, p. 245–271, 2015. DOI: https://doi.org/10.1210/er.2014-1100
VRIEZE, A. et al. "Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome". Gastroenterology, 2012.
XIA, T. et al. Dietary ZnO nanoparticles alter intestinal microbiota and inflammation in piglets. Oncotarget, v. 8, p. 64878–64891, 2017. DOI: https://doi.org/10.18632/oncotarget.17612
ZIMMERMANN, M. B. et al. Iron fortification effects on gut microbiota in African children. American Journal of Clinical Nutrition, v. 92, p. 1406–1415, 2010. DOI: https://doi.org/10.3945/ajcn.110.004564
Downloads
Published
License
Copyright (c) 2025 RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218
This work is licensed under a Creative Commons Attribution 4.0 International License.
Os direitos autorais dos artigos/resenhas/TCCs publicados pertecem à revista RECIMA21, e seguem o padrão Creative Commons (CC BY 4.0), permitindo a cópia ou reprodução, desde que cite a fonte e respeite os direitos dos autores e contenham menção aos mesmos nos créditos. Toda e qualquer obra publicada na revista, seu conteúdo é de responsabilidade dos autores, cabendo a RECIMA21 apenas ser o veículo de divulgação, seguindo os padrões nacionais e internacionais de publicação.
