OMEGA-3 AND ASPIRIN AS ADJUNCTS TO PERIODONTAL THERAPY: LITERATURE REVIEW

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DOI:

https://doi.org/10.47820/recima21.v3i5.1295

Keywords:

Polyunsaturated fatty acids, acetylsalicylic acid, periodontal treatment

Abstract

Studies on the effects of lipoxin metabolites (arachidonic acid) and omega-3 (ω-3) polyunsaturated fatty acids (specialized pro-resolving mediators) in association with the potentiating effects of acetylsalicylic acid (ASA) on the modulation and inflammatory resolution of periodontal disease, showed beneficial results as an adjuvant therapy to the treatment of periodontal disease. The present study aims to review the current literature on the effects of ω-3 and its combination with ASA in the treatment of periodontal disease. Double-blind, parallel design, randomized, placebo-controlled clinical trials were used as the literary basis for this literature review. The data obtained demonstrate improvements in periodontal clinical parameters, in the reduction of levels of pro-inflammatory biomarkers and in the modulation and resolution of the inflammatory response of periodontal disease, evidencing a favorable intervention in the inflammatory condition. It is noted that host immunomodulation therapy with ω-3 demonstrates benefits in clinical and inflammatory parameters according to current literature.

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Author Biographies

Rafael Nascimento de Brito Silva

Graduado em Odontologia pela Universidade Guarulhos. Atualmente, é mestrando em periodontia no programa de pós-graduação da Universidade Guarulhos.

Nidia Castro dos Santos

Dra. Castro dos Santos completou sua graduação em Odontologia na Universidade Estadual Paulista (UNESP) em São José dos Campos. É especialista em Periodontia. Possui mestrado em Microbiologia e Imunologia e doutorado em Periodontia pela UNESP. Realizou estágio de doutoramento no Forsyth Institute (Estados Unidos), no Centro de Pesquisa Clínica e Translacional, e pós-doutorado em Periodontia na Universidade Guarulhos. Atualmente é docente permanente do Programa de Pós-graduação em Odontologia na Universidade Guarulhos.

Magda Feres

Dra. Feres é periodontista (especialização e mestrado), Doutora em Biologia Oral pela Universidade de Harvard (EUA) e Pós-doutora em Microbiologia pelo Forsyth Institute (EUA). Ela é a coordenadora do Programa de Pós-Graduação em Odontologia da Universidade Guarulhos (único programa em Universidade particular com nota de excelência da CAPES) e Associate Professor do Forsyth.

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01/05/2022

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Nascimento de Brito Silva, R., Castro dos Santos, N., & Feres, M. (2022). OMEGA-3 AND ASPIRIN AS ADJUNCTS TO PERIODONTAL THERAPY: LITERATURE REVIEW. RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, 3(5), e351295. https://doi.org/10.47820/recima21.v3i5.1295

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