ASSOCIATION BETWEEN OBESITY AND PREMENOPAUSAL BREAST CANCER
DOI:
https://doi.org/10.47820/recima21.v3i10.2081Keywords:
Obesity, Breast cancer, PremenopausalAbstract
Considering the increase in the number of cases of cancer, especially breast cancer, it is evident the need to understand the risk factors of the disease. As obesity and cancer affect millions of people and have important consequences, it is necessary to identify the relationship between these two events. The aim of this study is to define whether there is an association between obesity and premenopausal breast cancer. An integrative literature review was conducted with the descriptors in Health Sciences "Obesity" AND "Breast cancer" AND "Premenopausal" in the following virtual libraries: MEDLINE, PUBMED, LILACS and SCIELO. Lines of evidence supporting the association of obesity with breast cancer include pathways related to inflammation, insulin resistance, and hormone synthesis. In premenopausal, studies indicate an inverse relationship between these two factors, i.e., obese patients would have a lower risk of cancer; with the exception of Asian women, who have an increased risk. However, obesity, when present, confers a worse prognosis, increased risk of recurrence and mortality from breast cancer in premenopausal women, especially because it is related to more aggressive tumor subtypes.
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