NETWORK OF LIPID MEDIATORS WITH AUTOIMMUNE DISEASES: A LITERATURE REVIEW

Abstract

Lipid mediators are organic molecules released in the inflammatory process that can be related to both physiological and pathological actions, as well as autoimmune diseases. At the onset of inflammation, pro-inflammatory lipid mediators contribute to vasodilation and recruitment of neutrophils; In the final stages, anti-inflammatory activation occurs, when the resolution process begins, resulting in the recruitment of cells at the injury site. Autoimmune diseases are able to arise from an exacerbated immune response, although etiologically distinct, these diseases are unified through the presence of unregulated immune components. This study sought to correlate the different lipid mediators with autoimmune diseases: Rheumatoid Arthritis, Systemic Lupus Erythematosus, Hashimoto's Thyroiditis and Multiple Sclerosis through a literature review. Bibliographic review using the academic Google, Medline, PubMed and SciELO as databases. The search was carried out on articles published from 2000 to 2020, in Portuguese and / or English. From the study it is possible to understand how a complexity of the immunoregulation of lipid mediators can elucidate the pathogenesis of autoimmune diseases, in addition to guiding future treatment strategies.