USE OF CANNABIDIOL AS AN ALTERNATIVE IN THE TREATMENT OF ATOPIC DERMATITIS AND PSORIASIS
DOI:
https://doi.org/10.47820/recima21.v4i11.4313Keywords:
cannabis, cannabidiol, dermatitis, psoriasis, treatmentAbstract
Atopic dermatitis and psoriasis are chronic inflammatory skin diseases with characteristic manifestations. Atopic dermatitis, associated with genetic predisposition, presents eczema due to a triad of causes: immune dysregulation, alteration of the skin microbiome and dysfunction of the skin barrier. There are theories that debate the sequence of these causes, with some claiming that barrier dysfunction triggers the immune response and others believing otherwise. Psoriasis is marked by the appearance of papulosquamous lesions and may be associated with psoriatic arthritis. Its pathophysiology is related to imbalances in the immune system, particularly involving CD4+, Th1 and Th17 cells. One plant, Cannabis sativa, has gained prominence in the treatment of these conditions due to the presence of cannabinoids, especially CBD. The endocannabinoid system, present in the human body, interacts with these cannabinoids, providing anti-inflammatory and antioxidant effects, which are beneficial for the treatment of atopic dermatitis and psoriasis. Studies point to the effectiveness of cannabinoids in inhibiting keratinocyte proliferation and modulating inflammatory components. However, further research is still needed to standardize doses and formulations, as well as to determine the safety and effectiveness of the medicinal use of Cannabis in dermatological conditions.
Downloads
References
DOMANSKY, C.R; BORGES, L.E. Manual para prevenção de lesões de pele. Recomendações baseadas em evidências. Rio de Janeiro: Editora Rubio,2012.
ANTUNES AA, et al. Guia prático de atualização em dermatite atópica - Parte I: etiopatogenia, clínica e diagnóstico. Arquivos de Asma, Alergia e Imunologia, 2017; 1(2): 131-56.
CZARNOWICKI T, et al. Atopic dermatitis endotypes and implications for targeted therapeutics. J Allergy Clin Immunol, 2019 Jan; 143(1): 1-11
BASLER K, et al. The role of tight junctions in skin barrier function and dermal absorption. J Control Release, 2016 Nov 28; 242: 105-118.
Belsito DV. The diagnostic evaluation, treatment, and prevention of allergic contact dermatitis in the new millennium. J Allergy Clin Immunol. 2000; 105:409-20.
WEIDINGER S, NOVAK N. Atopic dermatitis. Lancet, 2016; 387(10023): 1109-1122.
. DARLENSKI R, et al. Atopic dermatitis as a systemic disease. Clin Dermatol, 2014 May-Jun; 32(3): 409-13
Soutor C, Hordinsky M. Dermatologia clínica. Porto Alegre: Grupo A; 2014.
Rendon, A., & Schäkel, K. (2019). Psoriasis Pathogenesis and Treatment. International journal of molecular sciences, 20(6), 1475. https://doi.org/10.3390/ijms20061475
Kumar, V., Abbas, A., & Aster, J. (2016). Robbins & Cotran Patologia - Bases Patológicas das Doenças (9th edição). Grupo GEN. https://integrada.minhabiblioteca.com.br/books/9788595150966
Krueger, J. G., & Bowcock, A. (2005). Psoriasis pathophysiology: Current concepts of pathogenesis. Annals of the Rheumatic Diseases, 64(SUPPL. 2), 30–36. https://doi.org/10.1136/ard.2004.031120
11. Azulay, R. D. (2017). Dermatologia, (7ª edição.) Grupo GEN. https://integrada.minhabiblioteca.com.br/books/9788527732475
HAJAR T, et al. New and developing therapies for atopic dermatitis. An Bras Dermatol, 2018; 93(1): 104-107
CARVALHO VO, et al. Guia prático de atualização em dermatite atópica - Parte II: abordagem terapêutica. Arquivos de Asma, Alergia e Imunologia, 2017; 1(2): 157-82.
Association NE. Can cannabis help your eczema? What you need to know. [Internet]. National Eczema Association. 2017. Available from: https://nationaleczema.org/blog/can-marijuana-help/
Siegfried EC, Jaworski JC, Kaiser JD, Hebert AA. Systematic review of published trials: long-term safety of topical corticosteroids and topical calcineurin inhibitors in pediatric patients with atopic dermatitis. BMC pediatrics. 2016;16:75.
Eichenfield LF, Tom WL, Berger TG, Krol A, Paller AS, Schwarzenberger K, et al. Guidelines of care for the management of atopic dermatitis: Section 2. Management and treatment of atopic dermatitis with topical therapies. J Am Acad Dermatol. 2014;71:116-32
Sigurgeirsson B, Boznanski A, Todd G, Vertruyen A, Schuttelaar ML, Zhu X, et al. Safety and efficacy of pimecrolimus in atopic dermatitis: a 5-year randomized trial. Pediatrics. 2015;135(4):597-606
Sheriff, T., Lin, M. J., Dubin, D., & Khorasani, H. (2019). The potential role of cannabinoids in dermatology. J. Dermatolog Treat, 31 (8), 839-845.https://pubmed.ncbi.nlm.nih.gov/31599175/#:~:text=Cannabinoids%20have%20demonstrated%20anti%2Dinflammatory,promising%20alternative%20to%20traditional%20treatments
Bíró T, Tóth BI, Haskó G, Paus R, Pacher P. The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities. Trends in Pharmacological Sciences [Internet]. 2009 Aug;30(8):411–20. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757311/
Jarząb S. Cannabidiol – characteristic and application in cosmetology and dermatology [Internet]. Aesthetic Cosmetology. 2021 [cited 2023 Jun 17]. Available from: https://aestheticcosmetology.com/cannabidiol-characteristic-and-application-in- cosmetology-and-dermatology/
Grupta, A. K., & Talukder, M. (2021). Cannabinoids for skin diseases and hairre growth. Wiley Online Library, 20 (9), 2703-2711.https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.14352#:~:text=Skin%20disorders%20and%20hair%20growth,hair%20growth%20via%20multiple%20mechanisms
Cristino L, Bisogno T, Di Marzo V. Cannabinoid and the expanded endocannabinoid system in neurological disorders Nature Reviews Neurology [Internet]. 12 de janeiro de 2020 [citado 4 de fevereiro de 2020];16(1):9–29. Available at: http://www.nature.com/articles/s41582-019-0284-z
Baswan SM, Klosner AE, Glynn K, Rajgopal A, Malik K, Yim S, et al. Therapeutic Potential of Cannabidiol (CBD) for Skin Health and Disorders. Clinical, Cosmetic and Investigational Dermatology [Internet]. 2020; 13:927–42. Available from: https://pubmed.ncbi.nlm.nih.gov/33335413/
Viana LS, Aires Silva T, Antunes VM de S, Gonzaga RV. Efeito do óleo de Canabidiol (CBD) sobre a acne. Research, Society and Development. 2021 Nov 2;10(14): e306101422075.
Lee SF, Newton C, Widen R, Friedman H, Klein TW. Differential expression of cannabinoid CB2 receptor mRNA in mouse immune cell subpopulations and following B cell stimulation. Eur J Pharmacol. 2001;423(2-3):235-41.
Howlett AC. Cannabinoid receptor signaling. Handb Exp Pharmacol. 2005; 168:53- 79.
Marsicano G, Moosmann B, Hermann H, Lutz B, Behl C. Neuroprotective Properties of cannabinoids against oxidative stress: role of the cannabinoid receptor CB1. J Neurochem. 2002;80(3):448-56.
MARZO, Bisogno T, De Petrocellis L. Endocannabinoids: new targets for drug development. Curr Pharm Des. 2000 Sep;6(13):1361-80. doi: 10.2174/1381612003399365. PMID: 10903398.
MOREIRA, E. M. F., & de Sousa, M. N. A. (2021). USO TERAPÊUTICO DA CANNABIS SATIVA PARA O TRATAMENTO DE DOENÇAS. Journal of Medicine and Health Promotion, 6(1), 292-301.)
LUCENA, João Gabriel Almeida de. Canabinóides: do uso abusivo à aplicação terapêutica. Araraquara 77 f , 2021.
Coimbra BZ, Bertozzi JG, Borges ED, Pitliuk R, Fucci TPP da CS, Abreu MAMM de. Canabinóides como possível alternativa no tratamento de psoríase. Research, Society and Development [Internet]. 2022 Sep 18 [cited 2023 May 4];11(11): e450111134651–e450111134651. Available from: https://rsdjournal.org/index.php/rsd/article/view/34651
SCHIER , Alexandre Rafael de Mello et al. Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug. Brazilian Journal of Psychiatry [online]. 2012, v. 34, suppl one [Acessado 20 Junho 2022], pp. 104-110. Disponível em: <https://doi.org/10.1590/S1516-44462012000500008>. Epub 19 Jun 2012. ISSN 1809-452X. https://doi.org/10.1590/S1516-44462012000500008.
ELSAID, Sonja; KLOIBER, Stefan; LE FOLL, Bernard. Effects of cannabidiol (CBD) in neuropsychiatric disorders: A review of pre-clinical and clinical findings. In: PROGRESS IN MOLECULAR BIOLOGY AND TRANSLATIONAL SCIENCE. [S. l.]: Elsevier, 2019. v. 167, p. 25–75. Disponível em: https://doi.org/10.1016/bs.pmbts.2019.06.005. Acesso em: 24 mar. 2020.
Scheau, C., Badarau, I. A., Mihai, L. G., Scheau, A. E., Costache, D. O., Constantin, C., Calina, D., Caruntu, C., Costache, R. S., & Caruntu, A. (2020). Cannabinoids in the Pathophysiology of Skin Inflammation. Molecules (Basel, Switzerland), 25(3), 652. https://doi.org/10.3390/molecules25030652
Friedman, A. J., Momeni, K., & Kogan, M. (2020). Topical Cannabinoids for the Management of Psoriasis Vulgaris: Report of a Case and Review of the Literature.Journal of drugs in dermatology: JDD,19(8), 795. https://doi.org/10.36849/JDD.2020.5229
Ramot, Y., Sugawara, K., Zákány, N., Tóth, B. I., Bíró, T., & Paus, R. (2013). A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ. PeerJ, 1, e40. https://doi.org/10.7717/peerj.40
Norooznezhad, A. H., & Norooznezhad, F. (2017). Cannabinoids: Agents for treatment of psoriasis via suppression of angiogenesis and inflammation. Medical hypotheses, 99, 15–18. https://doi.org/10.1016/j.mehy.2016.12.003
Shao, K., Stewart, C., & Grant-Kels, J. M. (2021). Cannabis and the skin. Clinics in dermatology, 39(5), 784–795. https://doi.org/10.1016/j.clindermatol.2021.05.006
Lima, E. de A., & Lima, M. de A. (2011). Imunopatogênese da psoríase: revisando conceitos. Anais Brasileiros de Dermatologia, 86(6), 1151–1158. https://doi.org/10.1590/s0365-05962011000600014
Milano, R., & Friedman, A. (2019). Cannabinoids: potecial ole in inflammatory and neoplastic skin diseases. Am J Clin Dermatol, 20 (2), 167-180.https://pubmed.ncbi.nlm.nih.gov/30542832
Downloads
Published
How to Cite
License
Copyright (c) 2023 RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218
This work is licensed under a Creative Commons Attribution 4.0 International License.
Os direitos autorais dos artigos/resenhas/TCCs publicados pertecem à revista RECIMA21, e seguem o padrão Creative Commons (CC BY 4.0), permitindo a cópia ou reprodução, desde que cite a fonte e respeite os direitos dos autores e contenham menção aos mesmos nos créditos. Toda e qualquer obra publicada na revista, seu conteúdo é de responsabilidade dos autores, cabendo a RECIMA21 apenas ser o veículo de divulgação, seguindo os padrões nacionais e internacionais de publicação.
