USE OF CANNABIDIOL AS AN ALTERNATIVE IN THE TREATMENT OF ATOPIC DERMATITIS AND PSORIASIS
DOI:
https://doi.org/10.47820/recima21.v4i11.4313Keywords:
cannabis, cannabidiol, dermatitis, psoriasis, treatmentAbstract
Atopic dermatitis and psoriasis are chronic inflammatory skin diseases with characteristic manifestations. Atopic dermatitis, associated with genetic predisposition, presents eczema due to a triad of causes: immune dysregulation, alteration of the skin microbiome and dysfunction of the skin barrier. There are theories that debate the sequence of these causes, with some claiming that barrier dysfunction triggers the immune response and others believing otherwise. Psoriasis is marked by the appearance of papulosquamous lesions and may be associated with psoriatic arthritis. Its pathophysiology is related to imbalances in the immune system, particularly involving CD4+, Th1 and Th17 cells. One plant, Cannabis sativa, has gained prominence in the treatment of these conditions due to the presence of cannabinoids, especially CBD. The endocannabinoid system, present in the human body, interacts with these cannabinoids, providing anti-inflammatory and antioxidant effects, which are beneficial for the treatment of atopic dermatitis and psoriasis. Studies point to the effectiveness of cannabinoids in inhibiting keratinocyte proliferation and modulating inflammatory components. However, further research is still needed to standardize doses and formulations, as well as to determine the safety and effectiveness of the medicinal use of Cannabis in dermatological conditions.
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