APLICACIÓN DE LA RESONANCIA MAGNÉTICA NUCLEAR EN EL ANÁLISIS CUALITATIVO DE AMOXICICINA FUERA DE LA VIDA ÚTIL
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https://doi.org/10.47820/recima21.v3i3.1237Palabras clave:
Período de validez, RMN, amoxicilinaResumen
Este estudio presenta un análisis cualitativo del fármaco Amoxicixina suspensión 250mg/5ml, utilizando el método de Resonancia Magnética Nuclear (RMN). Se compararon los signos de ¹H-RMN y ¹³C-RMN de un patrón de amoxicilina con fármacos caducados (3 años) y en vida útil, y se observaron cambios en las señales referidas a la molécula de amoxicilina. Los fármacos no se sometieron a ningún tratamiento previo para su análisis y solo se disolvieron en dimetilsulxuro (DMSO-d6) para los experimentos y se realizaron con los mismos parámetros de ajuste del equipo. Para comparar los signos, los espectros se superpusieron y no se observó la ausencia de ninguno de los signos relacionados con el fármaco. El uso de la comparación de los signos fue muy intuitivo y fácil de interpretar y no se observaron diferencias significativas en los signos del fármaco en ambos fármacos, válidos y caducados.
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