AS FUNÇÕES DA MICROGLIA NA PROGRESSÃO DO ASTROCITOMA – ARTIGO DE REVISÃO LITERÁRIA
DOI:
https://doi.org/10.47820/recima21.v4i11.4286Palavras-chave:
Microglia. Astrocitoma. Fenótipo M1 e M2. Mutação genética. Progressão tumoral.Resumo
Este artigo apresenta as interações entre o glioma conhecido como astrocitoma, que tem 4 graus de malignidade de acordo com a OMS, e a célula imunologia cerebral microglia e como os mecanismos desta célula podem afetar o astrocitoma com sua diferenciação fenotípica antitumoral (M1) e pro-tumoral (M2), assim como outros fatores que podem ajudar na progressão do tumor e como as mutações nos genes IDH1 e IDH2, TP53 e NF1 podem desencadear a formação do astrocitoma. Tendo como objetivo a análise da interação entre a microglia e o astrocitoma, sendo um dos canceres cerebrais mais comuns, e como a célula imune através de certos mecanismos combater a neoplasia, e através de outros mecanismos ela pode ajudar na progressão do tumor. Como método para análise desse tema foram utilizados livros eletrônicos e artigos científicos nacionais e internacionais indexados em base de dados como Google acadêmico, Scielo, Pubmed entre outros para a confecção deste trabalho, os artigos selecionados foram escolhidos quanto ao desenvolvimento, resultados e discussão sobre o assunto com informações relevantes para o projeto. Após a análise, foi possível estabelecer a importância da mutação genética e das células presentes na estrutura cerebral para o desencadeamento de tumores como o astrocitoma, a partir da mutação de genes como NF1, IDH1 e IDH2, além da mutação do gene TP53 que são importantes no desenvolvimento do tumor. Também é possível concluir que a microglia tem um papel importante na progressão do tumor, através de sua diferenciação em M2.
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