INFLUENCE OF EXCESS WEIGHT ON THE PHYSIOPATHOLOGY OF POLYCYSTIC OVARY SYNDROME
DOI:
https://doi.org/10.47820/recima21.v3i1.1049Keywords:
Female infertility, Obesity, Insulin Resistance, Women´s healthAbstract
Polycystic ovary syndrome (PCOS) is a very common metabolic endocrine disorder in women in the phase between menarche and menopause. Some elements, such as the genetic, environmental and socioeconomic factor, are related to the development of this disorder,as well as the presence of clinical-pathological conditions, such as obesity,it is very common to increase the symptoms of PCOS in the presence of excessive consumption of simple carbohydrates, saturated fats and trans.In view of the above, the present research aimed to verify the association between overweight and progression of polycystic ovary syndrome.The work is a narrative review of the literature, based on scientific articles from the bibliographic databases PubMed and SciELO,articles dated between 2016 and 2021 are used as a priority.Weight excess leads to hyperandrogenism, promoting increased production and biological action of androgens in the body, mainly testosterone.This state reflects irregular menstruation, infertility and the presence of cysts in the ovaries.Thus, it can be concluded that the excess weight is directly related to the installation and/or exacerbation of PCOS and that the dietotherapeutic and style control essential to treat this condition.
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References
Nazni P. Association of western diet & lifestyle with decreased fertility. Indian J Med Res. 2014 Nov;140 Suppl(Suppl 1):S78-81.
Zubiría MG, Gambaro SE, Rey MA, Carasi P, Serradell MLÁ, Giovambattista A. Deleterious Metabolic Effects of High Fructose Intake: The Preventive Effect of Lactobacillus kefiri Administration. Nutrients. 2017; 9(5): 470. doi: 10.3390/nu9050470.
Słupecka M, Romanowicz K, Woliński J. Maternal High-Fat Diet during Pregnancy and Lactation Influences Obestatin and Ghrelin Concentrations in Milk and Plasma of Wistar Rat Dams and Their Offspring. Int J Endocrinol. 2016; 2016: 5739763. doi: 10.1155/2016/5739763. Epub 2016
Weir CB, Jan A. BMI Classification Percentile And Cut Off Points. 2021 Jun 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–.
Hickey M, Doherty DA, Atkinson H, Sloboda DM, Franks S, Norman RJ, Hart R. Clinical, ultrasound and biochemical features of polycystic ovary syndrome in adolescents: implications for diagnosis. Hum Reprod. 2011; 26(6): 1469-77. doi: 10.1093/humrep/der102. Epub 2011
Andrade VHL, Borges RS, Costa-Silva DR, Martins LM, Cunha-Nunes LC, Silva BB, et al. Current aspects of polycystic ovary syndrome: A literature review. Revista da Associação Médica Brasileira [online]. 2016, v. 62, n. 9 https://doi.org/10.1590/1806-9282.62.09.867.
Milczarek M, Kucharska A, Borowiec A. Difficulties in diagnostics of polycystic ovary syndrome in adolescents - a preliminary study. Pediatr Endocrinol Diabetes Metab. 2019; 25(3): 122-126. English. doi: 10.5114/pedm.2019.87177.
Palomba S, Santagni S, Falbo A, La Sala GB. Complications and challenges associated with polycystic ovary syndrome: current perspectives. Int J Womens Health. 2015; 7: 745-63. doi: 10.2147/IJWH.S70314.
Vital-Reyes VS, Lopez-Alarcón MG, Inda-Icaza P, Márquez-Maldonado C. Alteraciones metabólicas sutiles en adolescentes con obesidad y síndrome de ovario poliquístico [Subtle metabolic alterations in adolescents with obesity and polycystic ovarian syndrome]. Gac Med Mex. 2017; 153(Supl. 2): S34-S41. Spanish. doi: 10.24875/GMM.M17000005.
Carolo AL, Mendes MC, Rosa E Silva ACJS, Vieira CS, Silva de Sá MF, Ferriani RA, Reis RMD. Nutritional Counseling Promotes Changes in the Dietary Habits of Overweight and Obese Adolescents with Polycystic Ovary Syndrome. Rev Bras Ginecol Obstet. 2017; 39(12): 692-696. English. doi: 10.1055/s-0037-1607458. Epub 2017
Mokhtari Z, Gibson DL, Hekmatdoost A. Nonalcoholic Fatty Liver Disease, the Gut Microbiome, and Diet. Adv Nutr. 2017; 8(2): 240-252. doi: 10.3945/an.116.013151.
Abdou RM, Zhu L, Baker RD, Baker SS. Gut Microbiota of Nonalcoholic Fatty Liver Disease. Dig Dis Sci. 2016; 61(5): 1268-81. doi: 10.1007/s10620-016-4045-1. Epub 2016
Szczuko M, Sankowska P, Zapałowska-Chwyć M, Wysokiński P. Studies on the quality nutrition in women with polycystic ovary syndrome (PCOS). Rocz Panstw Zakl Hig. 2017; 68(1): 61-67.
Vatopoulou A, Tziomalos K. Management of obesity in adolescents with polycystic ovary syndrome. Expert Opin Pharmacother. 2020; 21(2): 207-211. doi: 10.1080/14656566.2019.1701655. Epub 2020 Jan 1.
Batista Filho M, Rissin A. A transição nutricional no Brasil: tendências regionais e temporais. Cadernos de Saúde Pública. 2003;19(suppl 1):S181–91. Epub 28 Ago 2006.
Committee on Accelerating Progress in Obesity Prevention; Food and Nutrition Board; Institute of Medicine. Accelerating Progress in Obesity Prevention: Solving the Weight of the Nation. Glickman D, Parker L, Sim LJ, Del Valle Cook H, Miller EA, editors. Washington (DC): National Academies Press (US); 2012 May 8.
Varlamov O. Western-style diet, sex steroids and metabolism. Biochim Biophys Acta Mol Basis Dis. 2017 May;1863(5):1147-1155. doi: 10.1016/j.bbadis.2016.05.025. Epub 2016 Jun 3.
Freeman AM, Pennings N. Insulin Resistance. 2021 Jul 10. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–.
Garg D, Tal R. Inositol Treatment and ART Outcomes in Women with PCOS. Int J Endocrinol. 2016; 2016:1979654. doi: 10.1155/2016/1979654. Epub 2016 Oct 4.
Paixão L, Ramos RB, Lavarda A, Morsh DM, Spritzer PM. Animal models of hyperandrogenism and ovarian morphology changes as features of polycystic ovary syndrome: a systematic review. Reprod Biol Endocrinol. 2017 Feb 10;15(1):12. doi: 10.1186/s12958-017-0231-z.
Hartstra AV, Bouter KE, Bäckhed F, Nieuwdorp M. Insights into the role of the microbiome in obesity and type 2 diabetes. Diabetes Care. 2015 Jan;38(1):159-65. doi: 10.2337/dc14-0769.
Boulangé CL, Neves AL, Chilloux J, Nicholson JK, Dumas ME. Impact of the gut microbiota on inflammation, obesity, and metabolic disease. Genome Med. 2016 Apr 20;8(1):42. doi: 10.1186/s13073-016-0303-2.
Scheithauer TP, Dallinga-Thie GM, de Vos WM, Nieuwdorp M, van Raalte DH. Causality of small and large intestinal microbiota in weight regulation and insulin resistance. Mol Metab. 2016 Jun 10;5(9):759-70. doi: 10.1016/j.molmet.2016.06.002.
Jiao N, Baker SS, Nugent CA, Tsompana M, Cai L, Wang Y, Buck MJ, Genco RJ, Baker RD, Zhu R, Zhu L. Gut microbiome may contribute to insulin resistance and systemic inflammation in obese rodents: a meta-analysis. Physiol Genomics. 2018 Apr 1;50(4):244-254. doi: 10.1152/physiolgenomics.00114.2017. Epub 2018 Jan 26.
He F, Li Y. The gut microbial composition in polycystic ovary syndrome with insulin resistance: findings from a normal-weight population. J Ovarian Res. 2021 Mar 27;14(1):50. doi: 10.1186/s13048-021-00799-9.
Barko PC, McMichael MA, Swanson KS, Williams DA. The Gastrointestinal Microbiome: A Review. J Vet Intern Med. 2018 Jan;32(1):9-25. doi: 10.1111/jvim.14875. Epub 2017 Nov 24.
Liu R, Zhang C, Shi Y, Zhang F, Li L, Wang X, Ling Y, Fu H, Dong W, Shen J, Reeves A, Greenberg AS, Zhao L, Peng Y, Ding X. Dysbiosis of Gut Microbiota Associated with Clinical Parameters in Polycystic Ovary Syndrome. Front Microbiol. 2017 Feb 28; 8:324. doi: 10.3389/fmicb.2017.00324.
Torres PJ, Siakowska M, Banaszewska B, Pawelczyk L, Duleba AJ, Kelley ST, Thackray VG. Gut Microbial Diversity in Women With Polycystic Ovary Syndrome Correlates With Hyperandrogenism. J Clin Endocrinol Metab. 2018 Apr 1;103(4):1502-1511. doi: 10.1210/jc.2017-02153.
Insenser M, Murri M, Del Campo R, Martínez-García MÁ, Fernández-Durán E, Escobar-Morreale HF. Gut Microbiota and the Polycystic Ovary Syndrome: Influence of Sex, Sex Hormones, and Obesity. J Clin Endocrinol Metab. 2018 Jul 1;103(7):2552-2562. doi: 10.1210/jc.2017-02799.
Thursby E, Juge N. Introduction to the human gut microbiota. Biochem J. 2017 May 16;474(11):1823-1836. doi: 10.1042/BCJ20160510.
Thackray VG. Sex, Microbes, and Polycystic Ovary Syndrome. Trends Endocrinol Metab. 2019 Jan;30(1):54-65. doi: 10.1016/j.tem.2018.11.001. Epub 2018 Nov 29.
Qi X, Yun C, Sun L, Xia J, Wu Q, Wang Y, Wang L, Zhang Y, Liang X, Wang L, Gonzalez FJ, Patterson AD, Liu H, Mu L, Zhou Z, Zhao Y, Li R, Liu P, Zhong C, Pang Y, Jiang C, Qiao J. Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome. Nat Med. 2019 Aug;25(8):1225-1233. doi: 10.1038/s41591-019-0509-0. Epub 2019 Jul 22. Erratum in: Nat Med. 2019 Sep;25(9):1459.
Ley RE. Gut microbiota in 2015: Prevotella in the gut: choose carefully. Nat Rev Gastroenterol Hepatol. 2016 Feb;13(2):69-70. doi: 10.1038/nrgastro.2016.4.
Lukens JR, Gurung P, Vogel P, Johnson GR, Carter RA, McGoldrick DJ, Bandi SR, Calabrese CR, Vande Walle L, Lamkanfi M, Kanneganti TD. Dietary modulation of the microbiome affects autoinflammatory disease. Nature. 2014 Dec 11;516(7530):246-9. doi: 10.1038/nature13788. Epub 2014 Sep 28.
Guo Y, Qi Y, Yang X, Zhao L, Wen S, Liu Y, Tang L. Association between Polycystic Ovary Syndrome and Gut Microbiota. PLoS One. 2016 Apr 19;11(4):e0153196. doi: 10.1371/journal.pone.0153196.
Sherman SB, Sarsour N, Salehi M, Schroering A, Mell B, Joe B, Hill JW. Prenatal androgen exposure causes hypertension and gut microbiota dysbiosis. Gut Microbes. 2018;9(5):400-421. doi: 10.1080/19490976.2018.1441664. Epub 2018 May 31.
Barrea L, Frias-Toral E, Verde L, Ceriani F, Cucalón G, Garcia-Velasquez E, Moretti D, Savastano S, Colao A, Muscogiuri G. PCOS and nutritional approaches: Differences between lean and obese phenotype. Metabol Open. 2021 Sep 13; 12:100123. doi: 10.1016/j.metop.2021.100123.
Rodriguez Paris V, Solon-Biet SM, Senior AM, Edwards MC, Desai R, Tedla N, Cox MJ, Ledger WL, Gilchrist RB, Simpson SJ, Handelsman DJ, Walters KA. Defining the impact of dietary macronutrient balance on PCOS traits. Nat Commun. 2020 Oct 16;11(1):5262. doi: 10.1038/s41467-020-19003-5.
Moran LJ, Ko H, Misso M, Marsh K, Noakes M, Talbot M, Frearson M, Thondan M, Stepto N, Teede HJ. Dietary composition in the treatment of polycystic ovary syndrome: a systematic review to inform evidence-based guidelines. J Acad Nutr Diet. 2013 Apr;113(4):520-45. doi: 10.1016/j.jand.2012.11.018. Epub 2013 Feb 16.
Meng Y, Bai H, Wang S, Li Z, Wang Q, Chen L. Efficacy of low carbohydrate diet for type 2 diabetes mellitus management: A systematic review and meta-analysis of randomized controlled trials. Diabetes Res Clin Pract. 2017 Sep;131:124-131. doi: 10.1016/j.diabres.2017.07.006. Epub 2017 Jul 8.
Faghfoori Z, Fazelian S, Shadnoush M, Goodarzi R. Nutritional management in women with polycystic ovary syndrome: A review study. Diabetes Metab Syndr. 2017 Nov;11 Suppl 1:S429-S432. doi: 10.1016/j.dsx.2017.03.030. Epub 2017 Apr 5.
Barrea L, Arnone A, Annunziata G, Muscogiuri G, Laudisio D, Salzano C, Pugliese G, Colao A, Savastano S. Adherence to the Mediterranean Diet, Dietary Patterns and Body Composition in Women with Polycystic Ovary Syndrome (PCOS). Nutrients. 2019 Sep 23;11(10):2278. doi: 10.3390/nu11102278.
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