INTERMITTENT FASTING: A VIEW ON DIABETES AND OBESITY

Authors

DOI:

https://doi.org/10.47820/recima21.v3i2.1096

Keywords:

Fasting, Intermittent fasting, Diabetes Mellitus, Obesity

Abstract

New modern habits are changing food dietary, for this reason, several diseases, including obesity and diabetes, are increasing in the world population. The rising demand for alternative treatment, for this reason, intermittent fasting has been put on evidence. To gather information regarding the possible effects of intermittent fasting on obesity and/or diabetes mellitus. A narrative literature review was carried out through advanced research in the PubMed, MEDLINE, SciELO, LILACS, and ScienceDirect databases with the following descriptors in English contained in the Health Sciences Descriptors (DeCS): “intermittent fasting”, “obesity” and “diabetes mellitus”. Twenty articles with Qualis A1, A2, B1, and B2, published on the period of 2016 to 2019, including all types of work, except case reports, all of those were involving the application or information about intermittent fasting associated with obesity and diabetes mellitus without specific results for intermittent fasting, with those criterion 2425 articles were found. Intermittent fasting intervention resulted in decreasing peripheral insulin resistance, weight, inflammation, and improvements in life quality. In conclusion, there are benefits to health promoted by intermittent fasting when compared with patients with diabetes mellitus and/or obesity, but these positive impacts on humans can't be confirmed without proper confirmation. More research in humans is needed to significantly assess the results obtained through intermittent fasting, especially studies with randomized controlled clinical trials, due to many studies nowadays are being made in animals, mostly on rodents.

Downloads

Download data is not yet available.

Author Biographies

  • Ray Braga Romero

    Universidade José do Rosário Vellano  - UNIFENAS

  • Lethícia Fernandes Jorge

    Graduanda em medicina na Universidade José do Rosário Vellano (UNIFENAS - Alfenas - Minas Gerais). Coordenadora de extensão da Liga Acadêmica de Genética Médica e presidente do Projeto Acompanhamento Social e Avaliação Clínica do Lar São Vicente de Paulo.

  • Sérgio Antônio Murad Neto

    Student of the 6th period of the medical course at the José do Rosário Vellano University (UNIFENAS). He was monitor of the subjects General Genetics I (2020/01), Functional Neuroanatomy I(2020/01) and Anatomy/Physiology(2020/1) . First Secretary of the League of Nutrology at Unifenas (2019), Scientific Coordinator of the League of Medical Genetics from Unifenas (2020) and First Secretary of the São Vicente de Paula de Alfenas Home Extension Project in 2020 and 2021. He is currently monitor of General Histology I (2021/1) and General Histology II (2021/2), First Secretary of the League of Medical Genetics at Unifenas (2021) and Coordinator of Events at the League of Angiology and Vascular Surgery at Unifenas (2021).

  • Carollayne Mendonça Rocha

    Carollayne Mendonça Rocha, 21 years old, medical student at the UNIFENAS-Universidade José do Rosário Vellano, currently a sixth semester student at the university.

  • Gabriel Henrique Ferracioli Alvarenga

    Atualmente Graduando em medicina na Universidade José do Rosário Vellano (UNIFENAS - Alfenas - Minas Gerais) desde 2019.Em 2019, foi representante de sala no primeiro semestre. Em 2020 foi coordenador científico da Liga Acadêmica de Oftalmologia, Vice-presidente da liga de Nutrologia, Presidente do Projeto de extensão diabetes eu cuido, monitor de ANATOMIA I e EMBRIOLOGIA também em 2020. Atualmente (2021) é presidente do projeto diabetes eu cuido, presidente do Diretório Acadêmico do curso de medicina da UNIFENAS, Tesoureiro do Projeto Acompanhamento Social e Avaliação Clínica do Lar São Vicente de Paulo . Realiza pesquisas visando a esfera clinica e cirurgia, e presentemente envolvido com pesquisa na linha de COVID-19.

  • Alessandra Cristina Pupin Silvério

    Possui graduação em farmácia-bioquímica pela Universidade Federal de Alfenas (1995), mestrado em Ciências Biológicas pela Universidade Federal de Alfenas (1999) e doutorado em Ciências farmacêuticas pela Universidade Federal de Alfenas (2016). Atualmente é professor titular da UNIVERSIDADE JOSÉ DO ROSÁRIO VELANO com tempo integral. Tem experiência na área de Farmácia como docente e pesquisadora, com ênfase em Avaliação e analises toxicológicas atuando principalmente nos seguintes temas: trabalhador rural, intoxicação, carboxiemoglobina, anticolinesterásicos e bolsa de sangue. Experiência como docente e pesquisadora em Medicina com ênfase em Bioquímica médica, diabetes e saúde coletiva, Professora nos cursos de Medicina, Farmácia , Biomedicina, nutrição e educação física. Coordenadora do Projeto Plantando e Colhendo Saúde responsável por saúde de trabalhadores rurais na regional de Saúde de Alfenas e Guaxupé - sul de Minas Gerais. Coordenadora do grupo de Pesquisa em Saúde Coletiva da UNIFENAS. MEMBRO DO COLEGIADO E NÚCLEO DOCENTE ESTRUTURANTE DO CURSO DE FARMÁCIA - MEMBRO DO NÚCLEO DOCENTE ESTRUTURANTE DO CURSO DE BIOMEDICINA- MEMBRO DO COMITÊ DE ÉTICA EM PESQUISA HUMANA - CONEP DA UNIVERSIDADE JOSÉ DO ROSÁRIO VELANO e MEMBRO DO CONSUNI - CONSELHO UNIVERSITÁRIO - UNIVERSIDADE JOSÉ DO ROSÁRIO VELLANO.

References

ANTONI, Rona et al. Effects of intermittent fasting on glucose and lipid metabolism. Proceedings Of The Nutrition Society. Cambridge, v.76, n.3, p. 361-368, Jan/Ago. 2017.

ANTONI, Rona et al. Investigation into the acute effects of total and partial energy restriction on postprandial metabolism among overweight/obese participants. British Journal Of Nutrition. [s.l.], v.115, n.6, p. 951-959, Mar. 2016.

BOUTANT, Marie et al. SIRT1 Gain of Function Does Not Mimic or Enhance the Adaptations to Intermittent Fasting. Cell Reports. [s.l.], v.14, n.9, p. 2068-2075, Mar. 2016.

CATENACCI, Victoria A. et al. A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity. Obesity (silver Spring). [s.l.], v.24, n.9, p. 1874-1883, Set. 2016.

CHENG, Aiwu et al. Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise, and Metabolic and Excitatory Challenges. Cell Metabolism. [s.l.], v.23, n.1, p. 128-142, Jan. 2016.

CORLEY, B. T. et al. Intermittent fasting in Type 2 diabetes mellitus and the risk of hypoglycaemia: a randomized controlled trial. Diabetic Medicine. Wellington, v.35, n.5, p. 588-594, Jan/Mai. 2018.

DA SILVA, Vanessa Oliveira; DOS SANTOS BATISTA, Átila. Efeitos do jejum intermitente para o tratamento da obesidade: uma revisão de literatura. Revista Da Associação Brasileira De Nutrição-RASBRAN. v. 12, n. 1, p. 164-178, 2021.

GOTTHARDT, Juliet D. et al. Intermittent Fasting Promotes Fat Loss With Lean Mass Retention, Increased Hypothalamic Norepinephrine Content, and Increased Neuropeptide Y Gene Expression in Diet-Induced Obese Male Mice. Endocrinology. [s.l.], v.157, n.2, p. 679-691, Fev. 2016.

HANNA, Marina Dias et al. Efeitos metabólicos do Jejum Intermitente: uma revisão de literatura. Brazilian Journal of Development, v. 7, n. 3, p. 32624-32634, 2021.

HARVIE, Michelle N. et al. Intermittent energy restriction induces changes in breast gene expression and systemic metabolism. Breast Cancer Research. [s.l.], v.18, n.1, p. 57, Mai. 2016.

JOSLIN, P. M. N.; Bell, R. K.; Swoap, S. J.. Obese mice on a high-fat alternate-day fasting regimen lose weight and improve glucose tolerance. Journal Of Animal Physiology And Animal Nutrition (Berl). [s.l.], v.101, n.5, p. 1036-1045, Out. 2017.

KIM, Kyoung-han et al. Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage. Cell Research. [s.l.], v.27, n.11, p. 1309-1326, Nov. 2017.

LI, Guolin et al. Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota. Cell Metabolism. [s.l.], v.26, n.4, p. 672-685, Out. 2017.

LIU, Bo et al. Intermittent fasting increases energy expenditure and promotes adipose tissue browning in mice. Nutrition. Adelaide, v.66, p. 38-43, Dez/Out. 2019.

MARTEL, Cécile et al. Knockdown of angiopoietin-like 2 mimics the benefits of intermittent fasting on insulin responsiveness and weight loss. Experimental Biology And Medicine. Montreal, v.243, p. 45-49, Set/Nov. 2018.

MATTSON, Mark P.; Longo, Valter D.; Harvied, Michelle. Impact of intermittent fasting on health and disease processes. Ageing Research Reviews. [s.l.], v.39, p. 46-58, Out. 2017.

MORO, Tatiana et al. Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males. Journal Of Translational Medicine. [s.l.], v.14, n.1, p. 290, Out. 2016.

PATTERSON, Ruth e. et al. Intermittent Fasting and Human Metabolic Health. Journal Of The Academy Of Nutrition And Dietetics. San Diego, v.115, n.8, p. 1203-1212, Abr/Ago. 2015.

POTTER, Gregory D M et al. Nutrition and the circadian system. British Journal Of Nutrition. [s.l.], v.116, n.3, p. 434-442, Ago. 2016.

TINSLEY, Grant M. et al. Time-restricted feeding in young men performing resistance training: A randomized controlled trial. European Journal Of Sport Science. [s.l.], v.17, n.2, p. 200-207, Mar. 2017.

YANG, Wanwei et al. Alternate-day fasting protects the livers of mice against high-fat diet-induced inflammation associated with the suppression of Toll-like receptor 4/nuclear factor κB signaling. Nutrition Research. [s.l.], v.36, n.6, p. 586-593, Jun. 2016.

ZUO, Li et al. Comparison of High-Protein, Intermittent Fasting Low-Calorie Diet and Heart Healthy Diet for Vascular Health of the Obese. Frontiers In Physiology. [s.l.], v.7, p. 350, Ago. 2016.

Downloads

Published

30/01/2022

Issue

Vol. 3 No. 2 (2022): EDITORIAL - CLICK HERE TO ACCESS THE ARTICLES

Section

ARTIGOS

Categories

License

Copyright (c) 2022 RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Os direitos autorais dos artigos/resenhas/TCCs publicados pertecem à revista RECIMA21, e seguem o padrão Creative Commons (CC BY 4.0), permitindo a cópia ou reprodução, desde que cite a fonte e respeite os direitos dos autores  e contenham menção aos mesmos nos créditos. Toda e qualquer obra publicada na revista, seu conteúdo é de responsabilidade dos autores, cabendo a RECIMA21 apenas ser o veículo de divulgação, seguindo os padrões nacionais e internacionais de publicação. 

How to Cite

INTERMITTENT FASTING: A VIEW ON DIABETES AND OBESITY. (2022). RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, 3(2), e321096. https://doi.org/10.47820/recima21.v3i2.1096