DEPRESSION AND DYSBIOSIS: SCIENTIFICS EVIDENCES
DOI:
https://doi.org/10.47820/recima21.v3i2.1108Keywords:
The literature points out that depression mayAbstract
Introduction: The literature points out that depression may be associated with an imbalance in the brain-gut-microbiota axis. Objective: The present study aims to discuss the relationship between dysbiosis and depression. Methodology: The search for articles was carried out in the following databases: Pubmed, Google Scholar, LILACS and Scielo, published between 2010 and 2021, using the descriptors “intestinal dysbiosis”, “microbiota”, “depression”. Results: 337 articles were found, published between 2012 and 2021 and we used 9 articles that make up this literature review. Results: Reports demonstrate that there is an imbalance between bacteria found in healthy individuals compared to patients with depression, suggesting that gut microbiota bacteria play a role in the development and/or maintenance of depression. However, the research presents itself without a characteristic microbiological pattern, which can be influenced by dietary, ethnic patterns or due to the presence of co-morbidities. CONCLUSION: Although there is strong evidence that there is a correlation between depression and dysbiosis, further studies are needed to trace the complete mechanism between these two conditions.
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- FLECK, M. P. d. A.; LAFER, B.; SOUGEY, E. B.; DEL PORTO, J. A. et al. Diretrizes da Associação Médica Brasileira para o tratamento da depressão (versão integral). Brazilian Journal of Psychiatry. v. 25, p. 114-122, 2003.
- RANG, R.; RITTER, J. M.; FLOWER, R. J.; HENDERSON, G. Rang&dale farmacologia. Elsevier, 2015.
- ROSA, J. R. da; SOUZA, M. C. de; ZANELLA, M.The interrelation ships between depression and intestinal dysbiosis: an integrative review. Research, Society and Development, [S. l.], v. 9, n. 10, 2020.
- MAKRIS, A.P; KARIANAKI.M; TSAMIS, K.I; STAVROULA, A.P. The role of thegut-brainaxis in depression: endocrine, neural, and immune pathways. Hormones, v 20, p.1-12,August 2020.
- CARDING, S.; VERBEKE, K.; VIPOND, D. T.; CORFE, B. M. et al. Dysbiosis of the gut microbiota in disease. Microbial Ecology in Health and Disease, v. 26, n. 1, p. 26191, 2015/12/01 2015.
- DE SOUSA, F. R.; DE CARVALHO, L. M. F.; LANDIM, L. A. Depressão e disbiose. Nutrição Brasil, v. 18, n. 3, p. 175-181, 2019.
- CHEUNG, S. G.; GOLDENTHAL, A. R.; UHLEMANN, A.-C.; MANN, J. J. et al.Systematic Review ofGut Microbiota and Major Depression. Frontiers in psychiatry v. 10, n. 34, 2019-February-11, 2019.
- JIANG, H.; LING, Z.; ZHANG, Y.; MAO, H. et al.Altered fecal microbiota composition in patientswith major depressivedisorder. Brain, Behavior, and Immunity, v. 48, p. 186-194, 2015.
- SUN, L.; ZHANG, H.; CAO, Y.; WANG, C. et al.Fluoxetine ameliorates dysbiosis in a depression model induced by chronicun predicted mild stress in mice. International journal of medical sciences, v. 16, n. 9, p. 1260-1270, 2019.
- CHEN, Y.-h.; XUE, F.; YU, S.-f.; LI, X.-s. et al.Gut microbiota dysbiosis in depressedwomen: The associationofsymptomseverityand microbiota function. Journal of Affective Disorders, v. 282, p. 391-400, 2021.
- KELLY, J. R.; BORRE, Y.; C, O. B.; PATTERSON, E. et al.Transferring the blues: Depression-associated gut microbiota induces neuro behavior alchangesintherat. J Psychiatr Res, v. 82, p. 109-118, Nov 2016.
- ZHENG, P.; ZENG, B.; ZHOU, C.; LIU, M. et al.Gutmicrobiomeremodelinginducesdepressive-like behaviorsthrough a pathwaymediatedbythehost'smetabolism. Mol Psychiatry, v. 21, n. 6, p. 786-796, Jun 2016.
- NASERIBAFROUEI, A.; HESTAD, K.; AVERSHINA, E.; SEKELJA, M. et al. Correlation between the human fecal microbiota and depression. Neurogastroenterol Motil, v. 26, n. 8, p. 1155-1162, Aug 2014.
-AIZAWA, E.; TSUJI, H.; ASAHARA, T.; TAKAHASHI, T. et al.PossibleassociationofBifidobacteriumand Lactobacillus in thegut microbiota ofpatientswith major depressivedisorder. J Affect Disord, v. 202, p. 254-257, Sep 15 2016.
- LIN, P.; DING, B.; FENG, C.; YIN, S. et al. Prevotella and Klebsiella proportions in fecal microbial communities are potentialcharacteristicparameters for patientswith major depressivedisorder. J Affect Disord, v. 207, p. 300-304, Jan 1 2017.
-MAES, M.; KUBERA, M.; LEUNIS, J. C.; BERK, M. Increased IgA andIgM responses againstgut Commensals in chronicdepression: furtherevidence for increasedbacterialtranslocationorleakygut. J Affect Disord, v. 141, n. 1, p. 55-62, Dec 1 2012.
- DEL PORTO, J. A. Conceito e diagnóstico. Brazilian Journal of Psychiatry. v. 21, p. 06-11, 1999.
- SCORZA, F. A.; GUERRA, A.; CAVALHEIRO, E. A.; CALIL, H. M. Neurogênese e depressão: etiologia ou nova ilusão? Brazilian Journal of Psychiatry. v. 27, p. 249-253, 2005.
- PAIXÃO, L. A.; DOS SANTOS CASTRO, F. F. J. U. C. d. S. Colonização da microbiota intestinal e sua influência na saúde do hospedeiro. Universitas ciencias da saúde. v. 14, n. 1, p. 85-96, 2016.
- MAGNE, F.; GOTTELAND, M.; GAUTHIER, L.; ZAZUETA, A. et al. The Firmicutes/Bacteroidetes Ratio: A Relevant Marker of Gut Dysbiosis in Obese Patients? Nutrients, v. 12, n. 5, p. 1474, 2020.
- NEISH, Andrew S. Microbes in gastrointestinal healthanddisease. Gastroenterology, v. 136, n. 1, p. 65-80, 2009.
- WEISS, G. A.; HENNET, T. Mechanismsandconsequencesof intestinal dysbiosis. Cell Mol Life Sci, v. 74, n. 16, p. 2959-2977, Aug 2017.
-MARESE, Angélica Cristina Milan; FICAGNA, Eduardo Jose et al. The mainmechanismsthat correlate gut microbiota withpathogenesisofdepression. FAG Journal of Health, v. 1, n. 3, p. 232, 2019.
- CAPUCO, A.; URITS, I.; HASOON, J.; CHUN, R. et al.Current Perspectives onGutMicrobiomeDysbiosisandDepression. Advances in Therapy, v. 37, n. 4, p. 1328-1346, 2020.
- MORAES, A. C et al. Microbiota intestinal e risco cardiometabólico: mecanismos e modulação dietética. Arquivos Brasileiros de Endocrinologia & Metabologia [online]. v. 58, n. 4, pp. 317-327, 2014.
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