INTERACTION OF THE INFLAMASOME WITH RESPIRATORY DISEASES
DOI:
https://doi.org/10.47820/recima21.v4i1.2632Keywords:
Inflamasome., Asthma., COPD., Lung cancer., Tuberculosis., Covid-19.Abstract
Introduction: The inflamasome is a multiprotein complex formed in the cytosol that has as function to generate the active forms of il-1B and IL-18 cytokines that will promote the inflammatory response in the individual. Activation of the inflamasome has as a consequence pyptosis, an inflammatory form of programmed cell death of macrophages characterized by swelling of cells, loss of plasma membrane integrity and release of pro-inflammatory cytokines (IL-1B, IL-18, TNF-alfa, IL-6 e IL-8. Thus, the participation of the inflamasome is confirmed in the pathogenesis of various inflammatory diseases, whose action is shaped by the type of activation and thus creating a different pathogenicprofile for each disease. Objective: Thus, this study sought to address the inflammation activation in the pathogenesis of respiratory tract diseases. Methodology: This is a literature review conducted based on the analysis of journals from the academic platform: Center for Biotechnology Information (PubMed). The search was delimeted in a range from 2001 to 2021, using the keywords: Inflamassoma; Asthma; COPD; Lower tract infection; Lung cancer; Tuberculosis; Covid-19. Development: The results obtained in the studies showed that there is an influence of inflammation on pathogenesis of the respiratory tract. Conclusion: Based on the information obtained, it was possible to observe the importance of inflamasome in the development of pathogenesis of some diseases of the respiratory tract as such asthma, chronic obstructive pulmonary disease (COPD), acute infections respiratory tract, lung cancer, tuberculosis and Covid-19.
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