COAGULOPATHY BIOMARKERS IN PATIENTS WITH COVID-19

Abstract

Introduction: COVID-19 is responsible for provoking a deep inflammatory response, which has consequently several procoagulant mechanisms. The aim of this study is to expose the relationships between coagulopathy markers in COVID-19 - D-D-Dummer, PT, PTTa and fibrinogen - with mortality rates and prognosis in patients affected by the disease. Methodology: This is an integrative review of the literature on coagulation markers in COVID-19 in relation to prognosis and mortality.  The question that guided the research was "What is the relationship between coagulation markers (D-Dummer, PT, PTTa and Fibrinogen) and prognosis and mortality in COVID-19?". After applying the inclusion and exclusion criteria, 43 articles were found, of which 5 were selected to write the present study. Results and discussion: the procoagulatory picture in COVID-19 appears with more evidence as the disease worsens in patients, possibly due to the "cytokine storm" during the initial stage of infection. Coagulation markers are important in predicting prognosis and risk classification of patients, as they may indicate high risk of disease from hemostatic disorders. With mortality in question, no studies were found that related coagulability and mortality markers. Thus, it is not possible to establish a direct connection between these two factors. Final considerations: Therefore, it is concluded that coagulopathy markers in COVID-19 can help define the patient's prognosis. However, it cannot be directly related to mortality due to the multifactoriality of the clinic involved in the disease.