HUMAN LEUKOCYTE ANTIGEN CLASS III: INTEGRATIVE REVIEW

Authors

DOI:

https://doi.org/10.47820/recima21.v5i3.4891

Keywords:

Major Histocompatibility Complex, Polymorphism, Diseases, Health, Immunology, Genetics

Abstract

Human Leukocyte Antigen Class III (HLA Class III) holds genetic polymorphisms that correlate with the etiopathogenesis, susceptibility and severity of diseases that affect humans. Objective: The study aims to clarify the role of polymorphisms and the actions present in HLA Class III in the symptoms and pathogenesis of chronic, autoimmune, inflammatory, carcinogenic and infectious diseases that affect humanity. Methodology: This is an Integrative Review, based on the acronym PCC and including the databases Virtual Health Library (VHL), Capes Periódicos, Google Scholar, Embase, Medical Literature Analysis and Retrieval System Online (MEDLINE), Brazilian Bibliography of Dentistry (BBO), ScienceDirect and Scopus. Terms of interest found in the Medical Subject Headings (MeSH) and in the Health Sciences Descriptors (DeCS) were used as descriptors. Results: 56 studies were retrieved, including 35 case-control articles, 3 in vivo study articles, 2 literature review articles, 15 cohort study articles and 1 case report article. HLA Class III polymorphisms are due to isolated and coordinated mutations with other gene loci. Conclusion: HLA Class III polymorphisms can directly or indirectly corroborate diseases that affect some human populations.

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Author Biographies

  • Luan Nascimento Mesquita

    Universidade Federal do Pará.

  • Brenda Pinto de Moraes

    Universidade da Amazônia.

  • Herika dos Santos Anijar

    Escola Superior da Amazonia.

  • Fernanda Farias de Alcântara Marchesan

    Universidade Federal do Pará.

  • Erika Vanessa Oliveira Jorge

    Universidade Federal do Pará.

  • Rebeca Fontenele Pinheiro

    Universidade do Estado do Pará.

  • Kássia Helena Silva Leitão

    Universidade do Estado do Pará.

  • Patricia Jeanne de Souza Mendonça Mattos

    Fundação Hemopa.

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Published

04/03/2024

How to Cite

HUMAN LEUKOCYTE ANTIGEN CLASS III: INTEGRATIVE REVIEW. (2024). RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, 5(3), e534891. https://doi.org/10.47820/recima21.v5i3.4891