ANTÍGENO LEUCOCITÁRIO HUMANO DE CLASSE III: REVISÃO INTEGRATIVA

Autores

DOI:

https://doi.org/10.47820/recima21.v5i3.4891

Palavras-chave:

Complexo de Histocompatibilidade, Polimorfismo, Doenças, Saúde, Imunologia, Genética

Resumo

O Antígeno Leucocitário Humano de Classe III (HLA de Classe III) detém polimorfismos genéticos que se correlacionam com a etiopatogênese, suscetibilidade e gravidade de doenças que afetam os seres humanos. Objetivo: o estudo visa esclarecer o papel dos polimorfismos e as ações presentes do HLA de Classe III na sintomatologia e na patogênese de doenças crônicas, autoimunes, inflamatórias, carcinogênicas e infecciosas que afetam a humanidade. Metodologia: Trata-se de uma Revisão Integrativa, com base no acrônimo PCC e incluindo as bases de dados Biblioteca Virtual de Saúde (BVS), Capes Periódicos, Google Scholar, Embase, Medical Literature Analysis and Retrieval System Online (MEDLINE), Bibliografia Brasileira de Odontologia (BBO), ScienceDirect e Scopus. Utilizou-se como descritores termos de interesse encontrados no Medical Subject Headings (MeSH) e no Descritores das Ciências da Saúde (DeCS). Resultados: foram recuperados 56 estudos, sendo que 35 artigos de caso-controle, 3 artigos de estudo in vivo, 2 artigos de revisão de literatura, 15 artigos de estudo de coorte e 1 artigo de relato de caso. Os polimorfismos do HLA de Classe III devem-se a mutações isoladas e coordenadas com outros locus gênicos. Conclusão: os polimorfismos do HLA de Classe III podem corroborar diretamente ou indiretamente para doenças que afetam algumas populações humanas.

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Biografia do Autor

  • Luan Nascimento Mesquita

    Universidade Federal do Pará.

  • Brenda Pinto de Moraes

    Universidade da Amazônia.

  • Herika dos Santos Anijar

    Escola Superior da Amazonia.

  • Fernanda Farias de Alcântara Marchesan

    Universidade Federal do Pará.

  • Erika Vanessa Oliveira Jorge

    Universidade Federal do Pará.

  • Rebeca Fontenele Pinheiro

    Universidade do Estado do Pará.

  • Kássia Helena Silva Leitão

    Universidade do Estado do Pará.

  • Patricia Jeanne de Souza Mendonça Mattos

    Fundação Hemopa.

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04/03/2024

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ANTÍGENO LEUCOCITÁRIO HUMANO DE CLASSE III: REVISÃO INTEGRATIVA. (2024). RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, 5(3), e534891. https://doi.org/10.47820/recima21.v5i3.4891