KETAMINE AS A THERAPEUTIC INTERVENTION IN PSYCHOTIC DEPRESSION AND TREATMENT-REFRACTORY DEPRESSION
DOI:
https://doi.org/10.47820/recima21.v5i8.5624Keywords:
Depression, Ketamine, Self-Extermination, Psychotic DisordersAbstract
According to the World Health Organization (WHO), depression will be the second leading cause of global disability by 2030. This disease is characterized by its heterogeneity and subtypes, which are classified by symptom variations. Objectives: to evaluate the use of ketamine as an intervention for severe psychotic depression and depression refractory to treatment. Materials and methods: This is an integrative review, in which the guiding question was “Is ketamine effective as a therapeutic intervention for psychotic depression and depression refractory to treatment?”. The search for articles was carried out in PubMed using the terms “depression refractory to treatment”, “psychotic depression” and “ketamine”, combined with each other by Boolean operators. Results and discussion: Ketamine is the first drug found to have an impact on treatment-resistant depression with immediate effect. It also appears to reduce the occurrence of suicidal thoughts and provides a rapid antidepressant effect with maximum efficacy reached after 24 hours. Short-term ketamine treatment may be a safe and effective option for patients with a history of psychosis or ongoing psychotic symptoms. Conclusion: New antidepressants are needed to treat depression that does not respond adequately to conventional treatment. Recent clinical trials show that ketamine is likely to be a revolutionary antidepressant, as it acts rapidly against suicidal ideation, as evidenced by decreased suicidal ideation, distress, and improvement in hallucinations.
Downloads
References
ADELL, Albert. Brain NMDA receptors in schizophrenia and depression. Biomolecules, v. 10, n. 6, p. 947, 2020. DOI: https://doi.org/10.3390/biom10060947
AJUB, Elias; LACERDA, Acioly LT. Efficacy of esketamine in the treatment of depression with psychotic features: a case series. Biological psychiatry, v. 83, n. 1, p. e15-e16, 2018. DOI: https://doi.org/10.1016/j.biopsych.2017.06.011
ANDRADE, Chittaranjan. Ketamine for depression, 1: clinical summary of issues related to efficacy, adverse effects, and mechanism of action. The Journal of clinical psychiatry, v. 78, n. 4, p. 10108, 2017. DOI: https://doi.org/10.4088/JCP.17f11567
CARVALHO, Tayse Cardoso Ferreira et al. A depressão infantil e o pedagogo em cena. Research, Society and Development, v. 10, n. 17, p. e04101724633-e04101724633, 2021. DOI: https://doi.org/10.33448/rsd-v10i17.24633
COELHO, Lilian Maria Godeiro et al. Análise da eficácia e segurança do uso da cetamina endovenosa na depressão unipolar resistente ao tratamento: revisão sistemática de ensaios clínicos randomizados. 2018.
CUSIN, Cristina et al. Ketamine augmentation for outpatients with treatment-resistant depression: preliminary evidence for two-step intravenous dose escalation. Australian & New Zealand Journal of Psychiatry, v. 51, n. 1, p. 55-64, 2017. DOI: https://doi.org/10.1177/0004867416631828
DA FROTA RIBEIRO, Carolina Medeiros et al. The use of ketamine for the treatment of depression in the context of psychotic symptoms: to the editor. Biological psychiatry, v. 79, n. 9, p. e65-e66, 2016. DOI: https://doi.org/10.1016/j.biopsych.2015.05.016
DE MENDONÇA, Thereza Gabrielly Lopes et al. Análise da saúde psíquica nos profissionais da saúde em tempos de Covid-19 Analysis of psychic health in health professionals in times of Covid-19. Brazilian Journal of Health Review, v. 4, n. 4, p. 14652-14665, 2021. DOI: https://doi.org/10.34119/bjhrv4n4-023
FRANCO, Fernanda Moreira et al. Os efeitos do uso da cetamina em pacientes com depressão resistente ao tratamento. Brazilian Journal of Development, v. 6, n. 6, p. 36999-37016, 2020. DOI: https://doi.org/10.34117/bjdv6n6-293
GAŁUSZKO-WȨGIELNIK, Maria et al. Central nervous system-related safety and tolerability of add-on ketamine to standard of care treatment in treatment-resistant psychotic depression in patients with major depressive disorder and bipolar disorder. Frontiers in Neuroscience, v. 17, p. 1214972, 2023. DOI: https://doi.org/10.3389/fnins.2023.1214972
GAŁUSZKO-WĘGIELNIK, Maria et al. Ketamine as add-on treatment in psychotic treatment-resistant depression. Brain Sciences, v. 13, n. 1, p. 142, 2023. DOI: https://doi.org/10.3390/brainsci13010142
GRUNEBAUM, Michael F. et al. Ketamine for rapid reduction of suicidal thoughts in major depression: a midazolam-controlled randomized clinical trial. American Journal of Psychiatry, v. 175, n. 4, p. 327-335, 2018. DOI: https://doi.org/10.1176/appi.ajp.2017.17060647
KOWALCZYK, Mateusz et al. Ketamine—new possibilities in the treatment of depression: a narrative review. Life, v. 11, n. 11, p. 1186, 2021. DOI: https://doi.org/10.3390/life11111186
MANDAL, Suprio; SINHA, Vinod Kumar; GOYAL, Nishant. Efficacy of ketamine therapy in the treatment of depression. Indian journal of psychiatry, v. 61, n. 5, p. 480-485, 2019. DOI: https://doi.org/10.4103/psychiatry.IndianJPsychiatry_484_18
MASCARENHAS, Anderson Lima; NASCIMENTO, Marinalva Cerqueira; PASSOS, Marcos Paulo Santos. Uso da cetamina na depressão resistente ao tratamento: uma revisão integrativa. Research, Society and Development, v. 11, n. 16, p. e16111637628-e16111637628, 2022. DOI: https://doi.org/10.33448/rsd-v11i16.37628
MENDES, Karina Dal Sasso; SILVEIRA, Renata Cristina de Campos Pereira; GALVÃO, Cristina Maria. Uso de gerenciador de referências bibliográficas na seleção dos estudos primários em revisão integrativa. Texto & Contexto-Enfermagem, v. 28, p. e20170204, 2019.
MENEZES, Itiana Castro; JURUENA, Mário Francisco. Diagnóstico de depressões unipolares e bipolares e seus especificadores. Medicina (Ribeirão Preto), v. 50, n. Supl 1, p. 64-71, 2017. DOI: https://doi.org/10.11606/issn.2176-7262.v50isupl1.p64-71
MORA, Rafael et al. Ketamina en el tratamiento de la ideación suicida asociada a depresión resistente. A propósito de un caso. Psiquiatria Biologica, v. 24, n. 1, p. 24-27, 2017. DOI: https://doi.org/10.1016/j.psiq.2016.11.002
NETTO, Antônio Bernardes et al. DEPRESSÃO PSICÓTICA ASSOCIADA A ESTRESSE PÓS-TRAUMÁTICO: ESTUDO DE CASO. Revista Brasileira de Neurologia e Psiquiatria, v. 26, n. 2, 2022.
PENNYBAKER, Steven J. et al. Ketamine and psychosis history: antidepressant efficacy and psychotomimetic effects postinfusion. Biological psychiatry, v. 82, n. 5, p. e35-e36, 2017. DOI: https://doi.org/10.1016/j.biopsych.2016.08.041
RIO, Carla Mafalda de Castro Ferreira Martins do. Depressão Unipolar e depressão bipolar: um espectro da doença depressiva?. 2011.
SOUZA, Marcela Tavares de; SILVA, Michelly Dias da; CARVALHO, Rachel de. Revisão integrativa: o que é e como fazer. Einstein (São Paulo), v. 8, p. 102-106, 2010. DOI: https://doi.org/10.1590/s1679-45082010rw1134
TAVARES, Diego Freitas. Avaliação da eficácia, segurança e tolerabilidade da estimulação magnética transcraniana modalidade theta-burst (TBS) nos transtornos bipolar e depressivo maior com características mistas: um ensaio clínico randomizado, controlado, duplo-cego e de grupo paralelos. 2021. Tese de Doutorado. Universidade de São Paulo.
VASILIU, Octavian. Esketamine for treatment‑resistant depression: A review of clinical evidence. Experimental and therapeutic medicine, v. 25, n. 3, p. 1-10, 2023. DOI: https://doi.org/10.3892/etm.2023.11810
WILKINSON, Samuel T. et al. The effect of a single dose of intravenous ketamine on suicidal ideation: a systematic review and individual participant data meta-analysis. American journal of psychiatry, v. 175, n. 2, p. 150-158, 2018. DOI: https://doi.org/10.1176/appi.ajp.2017.17040472
WŁODARCZYK, Adam et al. Single arketamine in treatment resistant depression: Presentation of 3 cases with regard to sick-leave duration. Asian Journal of Psychiatry, v. 96, p. 104016, 2024. DOI: https://doi.org/10.1016/j.ajp.2024.104016
XU, Ying et al. Effects of low-dose and very low-dose ketamine among patients with major depression: a systematic review and meta-analysis. International Journal of Neuropsychopharmacology, v. 19, n. 4, p. pyv124, 2016. DOI: https://doi.org/10.1093/ijnp/pyv124
Downloads
Published
License
Copyright (c) 2024 RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218
This work is licensed under a Creative Commons Attribution 4.0 International License.
Os direitos autorais dos artigos/resenhas/TCCs publicados pertecem à revista RECIMA21, e seguem o padrão Creative Commons (CC BY 4.0), permitindo a cópia ou reprodução, desde que cite a fonte e respeite os direitos dos autores e contenham menção aos mesmos nos créditos. Toda e qualquer obra publicada na revista, seu conteúdo é de responsabilidade dos autores, cabendo a RECIMA21 apenas ser o veículo de divulgação, seguindo os padrões nacionais e internacionais de publicação.
