INCIDENCE OF ACUTE PANCREATITIS FROM GLP-1 RECEPTOR AGONISTS USAGE
DOI:
https://doi.org/10.47820/recima21.v5i9.5669Keywords:
pancreatitis; incretins; glucagon-like peptide-1.Abstract
Incretins are appetite-regulating hormones secreted by the intestine in response to food intake. Glucagon-like peptide (GLP-1) is an example, with the action of increasing insulin release and decreasing glucagon release. GLP-1 mimetics, such as Liraglutide or Semaglutide, have been used to treat type 2 diabetes mellitus and, recently, to treat obesity. However, there is concern about their use due to the risk of worrying side effects, such as acute pancreatitis. Objectives: to evaluate the incidence of acute pancreatitis cases due to the use of GLP-1 analogue drugs. Materials and methods: This is an integrative review, in which the guiding question was “Can GLP-1 analogues lead to the development of acute pancreatitis?”. The search for articles was carried out in the PubMed database using the terms “Glucagon-like peptide”, “pancreatitis” and “GLP-1 analogs”, combined with each other by the Boolean operator AND. Results and discussion: The results demonstrated that GLP-1 analogs have a low potential to lead to the development of acute pancreatitis. Among the articles that found this correlation, some factors, such as certain previous pathologies of the patients, may have been a confounding factor, considering that these patients would already have a predisposition to develop acute pancreatitis. Conclusion: It is suggested that some agonists have a very low risk of developing pancreatitis, and individual risk factors for pancreatitis should be taken into account when prescribing such medication.
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