INTRAVENOUS FERRIC CARBOXYMALTOSE IN THE TREATMENT OF HEART FAILURE: EFFECTS ON PATIENTS WITH PRESERVED AND REDUCED EJECTION FRACTION
DOI:
https://doi.org/10.47820/recima21.v6i3.6266Keywords:
Heart failure. Iron deficiency. Preserved ejection fraction. Reduced ejection fraction. Intravenous ferric carboxymaltose.Abstract
Iron deficiency significantly impacts heart failure (HF), exacerbating mitochondrial dysfunction and oxidative stress. Studies suggest that iron replenishment, especially via ferric carboxymaltose (FCM), improves functional capacity and prognosis in patients with HF and iron deficiency. This study aims to analyze the effects of FCM in different ejection fraction profiles, contributing to the improvement of therapeutic management of HF. Objective: To review the literature on the efficacy of intravenous iron replenishment with FCM in patients with HF, both with reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF), evaluating its impacts on functional capacity, symptoms, and hospitalizations. Methods: The review was conducted with articles from the last 16 years, consulting PubMed, Scielo, Embase, and MedLine. Five original studies and reviews were selected, focusing on the efficacy of intravenous ferric carboxymaltose in heart failure, with strict inclusion and exclusion criteria. Results and Discussion: Treatment with ferric carboxymaltose (FCM) showed significant benefits in patients with heart failure and iron deficiency, improving functional capacity, symptoms, and quality of life. FCM supplementation increased exercise capacity and ventricular function, with no severe adverse effects. However, limitations such as the small number of patients and lack of changes in some biomarkers suggest the need for further studies. Conclusion: FCM therapy improved exercise capacity and cardiovascular function in heart failure, but limitations suggest the need for more studies to assess long-term effects and in different profiles.
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