PROLONGED AND INTERMITTENT INFUSION OF MEROPENEM - IMPACTS ON MORTALITY AND BACTERIOLOGICAL EFFICACY IN PATIENTS WITH SEPSIS: A SYSTEMATIC REVIEW
DOI:
https://doi.org/10.47820/recima21.v6i5.6372Keywords:
Mortality. Sepsis. Continuous Infusion. Intermittent Infusion Meropenem.Abstract
Prolonged and intermittent infusion of meropenem are therapeutic strategies used in the treatment of severe infections caused by multidrug-resistant pathogens, especially in intensive care settings. Methodology: Consists of a systematic review carried out through the Scopus, PubMed® and SciELO databases, using the descriptors: rituximab, neuromyelitis optica and treatment. Studies published in the last 8 years, without language restrictions, that addressed the topic were included. Results and discussions: Some studies indicate that prolonged infusion can reduce mortality and improve clinical response in patients with severe conditions, such as sepsis and febrile neutropenia. However, there is no consensus on the impact on length of hospital stay or mortality, with some studies showing no significant differences in these aspects. Conclusions: It is concluded that the choice between prolonged and intermittent infusion should be made on an individualized basis, taking into account the severity of the infection, the patient's profile and bacterial resistance. More research is needed to accurately identify the scenarios in which prolonged infusion offers greater clinical benefit.
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