THE USE OF PROPOLIS IN THE DISINFECTION OF THE ROOT CANAL DURING ENDODONTIC TREATMENT

Authors

  • Gustavo Dudu-Silva
  • Gabriela Santos Dourado
  • Bruno Bueno-Silva

DOI:

https://doi.org/10.47820/recima21.v1i1.888

Keywords:

Propolis, Endodontic treatment, Irrigation solution, Natural products

Abstract

The endodontic success rate varies between 86% and 98%, but for these values ​​to be achieved, it is essential to remove any and all microorganisms from the root canal. To achieve long-term treatment success, excellent endodontic disinfection is required. During handling, instrumentation is essential, however, it alone does not promote complete elimination of bacteria, thus the importance of antimicrobial substances for the elimination of microorganisms arises. Currently, the main endodontic irrigants are Sodium Hypochlorite (NaOCl) and Chlorhexidine (CHX), but despite being widely used, they can be toxic and harmful to periapical tissues. Several substances are being researched in order to find the ideal antimicrobial solution and one of them is propolis. Therefore, the aim of this study is to evaluate the effectiveness of propolis in root canal disinfection, when compared to CHX and NaOCl, based on the literature. The propolis collected from plants by bees is a resinous and biocompatible substance, in addition to having antibacterial, anti-inflammatory, antitumor, antifungal, etc. properties. Based on the articles surveyed, it was observed that the Enterococcus faecalis species stood out as the main pathogen responsible for the failure of endodontic treatment. Research shows that propolis has shown effectiveness against Candida Albicans, Enterococcus faecalis, Staphylococcus aureus, Prevotella and Actinomyces, in different forms of research. Based on this study, we conclude that propolis, despite not being the most effective irrigating agent compared to the others, has been arousing interest in research because it is a solution that presents excellent results against endodontic microorganisms.

Downloads

Download data is not yet available.

Author Biography

  • Gustavo Dudu-Silva

    UNIVERSIDADE GUARULHOS/ Ser educacional/ UNIVERITAS

References

ALGHAMDI, F.; SHAKIR, M. The Influence of Enterococcus faecalis as a Dental Root Canal Pathogen on Endodontic Treatment: A Systematic Review. Cureus, v. 12, n. 3, p. 1-10, mar. 2020.

AWAWDEH, L.; JAMLEH, A.; AL BEITAWI, M. The Antifungal Effect of Propolis Endodontic Irrigant with Three Other Irrigation Solutions in Presence and Absence of Smear Layer: An In Vitro Study. Iranian Endodontic Journal, v. 13, n. 2, p. 234-239. 2018.

BUENO-SILVA, B.; FRANCHIN, M.; ALVES, CF.; DENNY, C.; COLÓN, DF.; CUNHA, TM.; ALENCAR, SM.; NAPIMOGA, MH.; ROSALEN, PL. Main pathways of action of Brazilian red propolis on the modulation of neutrophils migration in the inflammatory process. Phytomedicine, v. 23, n. 13, p. 1583-1590. 2016.

BUENO-SILVA, B.; KAWAMOTO, D.; ANDO-SUGUIMOTO, ES.; ALENCAR, SM.; ROSALEN, PL.; MAYER, MPA. Brazilian Red Propolis Attenuates Inflammatory Signaling Cascade in LPS-Activated Macrophages. PLoS ONE, v. 10, n. 12, p. 1-14. 2015.

BUENO-SILVA, B.; KAWAMOTO, D.; ANDO-SUGUIMOTO, ES.; CASARIN, RCV.; ALENCAR, SM.; ROSALEN, PL.; MAYER, MPA. Brazilian red propolis effects on peritoneal macrophage activity: Nitric oxide, cell viability, pro-inflammatory cytokines and gene expression. Journaul of Ethnopharmacology, v. 31, n. 207, p. 100-107. 2017.

CHUGAL, NM.; CLIVE, JM.; SPÅNGBERG, LS. Endodontic infection: some biologic and treatment factors associated with outcome. Oral Surgery, Oral Medicine, Oral Pathology Oral Radiology and Endodontics, v. 96, n. 1, p. 81-90, jul. 2003.

DUTNER, J.; MINES, P.; ANDERSON, A. Irrigation trends among American Association of Endodontists members: a Web-based survey. Journal of Endodontics, v. 38, n. 1, p. 37–40. 2012.

ESTRELA, C.; ESTRELA, CRA.; BARBIN, EL.; SPANÓ, JCE.; MARCHESAN, MA.; PÉCORA, JD. Mechanism of action of sodium hypochlorite. Brazilian Dental Journal, v. 13, n. 1, p. 113-117. 2002.

ESTRELA, C.; ESTRELA, CRA.; DECURCIO, DA.; HOLLANDA, ACB.; SILVA, JA. Antimicrobial efficacy of ozonated water, gaseous ozone, sodium hypochlorite and chlorhexidine in infected human root canals. International Endodontic Journal, v. 40, n. 1, p. 85-93. 2007.

ESTRELA, C.; RIBEIRO, RG.; ESTRELA, CR.; PECORA, JD.; SOUSA-NETO, MD. Antimicrobial effect of 2% sodium hypochlorite and 2% chlorhexidine tested by different methods. Brazilian Dental Journal, v. 14, n. 1, p. 58-62. 2003.

ESTRELA, C; HOLLAND, R.; ESTRELA, CRA.; ALENCAR, AHG.; SOUZA-NETO, MD.; PÉCORA, JD. Characterization of Successful Root Canal Treatment. Brazilian Dental Journal, v. 25, n. 1, p. 3-11. 2014.

ESTRELA, CRA.; ESTRELA, C.; REIS, C.; BAMMANN, LL.; PÉCORA, JD. Control of microorganisms in vitro by endodontic irrigants. Brazilian Dental Journal, v. 14, n. 1, p. 187-192. 2003.

EUROPEAN SOCIETY OF ENDODONTOLOGY. Quality guidelines for endodontic treatment: consensus report of the European Society of Endodontology. International Endodontic Journal, v. 39, n. 1, p. 921–930. 2006.

EUROPEAN SOCIETY OF ENDODONTOLOGY. Undergraduate curriculum guidelines for endodontology. International Endodontic Journal, v. 34, n. 8, p. 574-80, dec. 2001.

GONDIM, BLC.; VIEIRA, TI.; CUNHA, DA.; SANTIAGO, BM. Atividade Antimicrobiana de Produtos Naturais Frente a Bactérias. Pesquisa Brasileira em Odontopediatria e Clínica Integrada, v. 11, n. 1, p. 123-127. 2011.

GUO, H.; GAO, C.; ZHANG, C.; ZHENG, S.; YUE, L. Morphology of bacterial flora in root canals associated with apical abscesses. Chinese Medical Journal (Engl), v. 127, n. 18, p. 3254-8. 2014.

HAAPASALO, M.; SHEN, Y.; QIAN, W.; GAO, Y. Irrigation in endodontics. Dental Clinics of North America, v. 54, n. 2, p. 291-312. 2010.

UGAR, SM.; KUKREJA, P.; HUGAR, SS.; GOKHALE, N.; ASSUDANI, H. Comparative Evaluation of Clinical and Radiographic Success of Formocresol, Propolis, Turmeric Gel, and Calcium Hydroxide on Pulpotomized Primary Molars: A Preliminary Study. International Journal of Clinical Pediatric Dentistry, v. 10, n. 1, p. 18-23, jan-mar. 2017.

JAISWAL, N.; SINHA, DJ.; SINGH, UP.; SINGH, K.; JANDIAL, UA.; GOEL, S. Evaluation of antibacterial efficacy of Chitosan, Chlorhexidine, Propolis and Sodium hypochlorite on Enterococcus faecalis biofilm: An in vitro study. Journal of Clinical and Experimental Dentistry, v. 9, n. 9, p. 1066-1074. 2017.

JOLLY, M.; SINGH, N.; RATHORE, M.; TANDON, S.; SHARMA, S. Propolis and commonly used intracanal irrigants. Comparative evaluation of inflammatory potential. Journal of Clinical Pediatric Dentistry, v. 37, n. 4, p. 373-6. 2020.

KAYAOGLU, G.; ÖMÜRLÜ, H.; AKCA, G.; GÜREL, M.; GENÇAY, Ö.; SORKUN, K.; SALIH, B. Antibacterial activity of Propolis versus conventional endodontic disinfectants against Enterococcus faecalis in infected dentinal tubules. Journal of Endodontics, v. 37, n. 3, p. 376-81. 2011.

KOÇ, S.; DEL FABBRO, M. Does the Etiology of Pulp Necrosis Affect Regenerative Endodontic Treatment Outcomes? A Systematic Review and Meta-analyses. Journal of Evidence-Based Dental Practice, v. 20, n. 1, p. 1-10, mar. 2020.

KUMAR, J.; SHARMA, R.; SHARMA, M.; PRABHAVATHI, V.; PAUL, J.; CHOWDARY, CD. Presence of Candida albicans in Root Canals of Teeth with Apical Periodontitis and Evaluation of their Possible Role in Failure of Endodontic Treatment. Journal of International Oral Heal, v. 7, n. 1, p. 42-5. 2015.

KURUVILLA, JR.; KAMATH, MP. Antimicrobial activity of 2.5% sodium hypochlorite and 0.2% chlorhexidine gluconate separately and combined, as endodontic irrigants. Journal of Endodontics, v. 24, n. 7, p. 472-6, jul. 1998.

MATTIGATTI, S.; RATNAKAR, P.; MOTURI, S.; VARMA, S.; RAIRAM, S. Antimicrobial effect of conventional root canal medicaments vs propolis against Enterococcus faecalis, Staphylococcus aureus and Candida albicans. Journal Contemporary Dental Practice, v. 13, n. 3, p. 305-9. 2012.

METO, A.; METO, A.; BIMBARI, B.; SHYTAJ, K.; OZCAN, M. Anti-Inflammatory and Regenerative Effects of Albanian Propolis in Experimental Vital Amputations. European Journal of Prosthodontics and Restorative Dentistry, v. 24, n. 3, p. 145-51. 2016

MURAD, CF.; SASSONE, LM.; FAVERI, M.; HIRATA, R Jr.; FIGUEIREDO, L.; FERES, M. Microbial diversity in persistent root canal infections investigated by checkerboard DNA-DNA hybridization. Journal of Endodontics, v. 40, n. 7, p. 899-906. 2004.

NAIR, PNR.; HENRY, S.; CANO, V.; VERA, J. Microbial status of apical root canal system of human mandibular first molars with primary apical periodontitis after ‘one-visit’ endodontic treatment. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, v. 99, n. 1, p. 231-252. 2005.

NEELAKANTAN, P.; ROMERO, M.; VERA, J.; DAOOD, U.; KHAN, AU.; YAN, A.; CHEUNG, GSP. Biofilms in Endodontics—Current Status and Future Directions. International Journal of Molecular Sciences, v. 18, n. 8, p. 1748. 2017.

NEIVA, KG.; CATALFAMO, DL.; HOLLIDAY, S.; WALLET, SM.; PILEGGI, R. Propolis decreases lipopolysaccharide-induced inflammatory mediators in pulp cells and osteoclasts. Dental Traumatology, v. 30, n. 5, p. 362-7. 2014.

PARK, YK.; ALENCAR, SM.; AGUIAR, CL. Botanical origin and Chemical composition of Brazilian propolis. Journal of Agricultural and Food Chemistry, v. 50, n. 1, p. 2502-2506. 2002.

PAROLIA, A.; KUMAR, H.; RAMAMURTHY, S.; DAVAMANI, F.; PAU, A. Effectiveness of chitosan-propolis nanoparticle against Enterococcus faecalis biofilms in the root canal. BMC Oral Health, v. 20, n. 1, p. 339-353. 2020.

PAROLIA, A.; KUMAR, H.; RAMAMURTHY, S.; MADHESWARAN, T.; DAVAMANI, F.; PICHIKA, MR.; MAK, KK.; FAWZY, AS; DAOOD, U.; PAU, A. Effect of Propolis Nanoparticles against Enterococcus faecalis Biofilm in the Root Canal. Molecules, v. 26, n.3, p. 715-32. 2021.

PRADA, I.; MICÓ-MUÑOZ, P.; GINER-LLUESMA, T.; MICÓ-MARTÍNEZ, P.; COLLA-DO-CASTELLANO, N.; MANZANO-SAIZ, A. Influence of microbiology on endodontic failure. Literature review. Medicina Oral Patologia Oral y Cirugia Bucal, v. 1;24, n. 3, p. 364-72, may. 2019.

RUKSAKIET, K.; HANÁK, L.; FARKAS, N.; HEGYI, P.; SADAENG, W.; CZUMBEL, LM.; SANG-NGOEN, T.; GARAMI, A.; MIKÓ, A.; VARGA, G.; LOHINAI, Z. Antimicrobial Efficacy of Chlorhexidine and Sodium Hypochlorite in Root Canal Disinfection: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Journal of Endodontics, v. 46, n. 8, p. 1032-1041.e7, aug. 2020.

SFORCIN, J.M. Biological Properties and Therapeutic Applications of Propolis. Phytotherapy Research, v. 30, n. 6, p. 894–905. 2016.

SFORCIN, J.M.; BANKOVA, V. Propolis: Is there a potential for the development of new drugs?. Journal of Ethnopharmacology, v. 133, n. 1, p. 253–260. 2011.

SFORCIN, J.M.; BANKOVA, V.; KUROPATNICKI, A.K. Medical Benefits of Honeybee Products. Evidence-Based Complementary and Alternative Medicine, v. 2017, n. 1, p. 1-2. 2017.

SILVA, F.; FRANCISCO, NLSG.; BRUM, SC.; BARBOSA, CCN.; SOARES, LC. ATIVIDADE ANTIMICROBIANA DE SOLUÇÕES IRRIGADORAS NO PREPARO BIOMECÂNICO DE CANAIS RADICULARES FRENTE A Enterococus faecalis. Brazilian Journal of Surgery and Clinical Research, v. 15, n. 1, p. 34-38. 2016.

SILVA, J.C.; RODRIGUES, S.; FEÁS, X.; ESTEVINHO, L.M. Antimicrobial activity, phenolic profile and role in the inflammation of propolis. Food and Chemical Toxicology, v. 50, n. 1, p. 1790–1795. 2012.

SIQUEIRA, AL.; DANTAS, CG.; GOMES, MZ.; PADILHA, FF.; ALBUQUERQUE JUNIOR, RLC.; Cardoso, JC. Estudo da ação antibacteriana do extrato hidroalcoólico de própolis vermelha sobre Enterococcus faecalis. Revista de Odontologia Da UNESP, v. 43, n. 6, p. 359–366. 2014.

SOCRANSKY, SS.; SMITH, C.; MARTIN, L.; PASTER, BJ.; DEWHIRST, FE.; LEVIN, AE. ‘‘Checkerboard’’ DNA-DNA hybridization. Biotechniques, v. 17, n. 4, p. 788-92. 1994.

TORETI, VC.; SATO, HH.; PASTORE, GM.; PARK, YK. Recent progress of propolis for its biological and chemical compositions and its botanical origin. Evidence-Based Complementary Alternative Medicine, v. 2013, n. 1, p. 1-13. 2013.

UĞUR AYDIN, Z.; AKPINAR, KE.; HEPOKUR, C.; ERDÖNMEZ, D. Assessment of toxicity and oxidative DNA damage of sodium hypochlorite, chitosan and propolis on fibroblast cells. Brazilian Oral Research, v. 32 n. 29, p. 119-126, nov. 2018.

UZEL, A.; SORKUN, K.; ONCAG, O.; COGULU, D.; GENCAY, O.; SALIH, B. Chemical compositions and antimicrobial activities of four different Anatolian propolis samples. Microbiol Research, v. 160 n. 2, p. 189-95. 2005.

VERMA, MK.; PANDEY, RK.; KHANNA, R.; AGARWAL, J. The antimicrobial effectiveness of 25% propolis extract in root canal irrigation of primary teeth. Journal of Indian Society of Pedodontics and Preventive Dentistry, v. 32, n. 2, p. 120-4. 2014.

WANDER, P. Taking the sting out of dentistry. Dental Practice, v. 25, n.1, p. 3-4. 1995.

Published

08/11/2021

Issue

Section

COURSE COMPLETION WORK - TCC

Categories

How to Cite

THE USE OF PROPOLIS IN THE DISINFECTION OF THE ROOT CANAL DURING ENDODONTIC TREATMENT. (2021). RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, 1(1), e210888. https://doi.org/10.47820/recima21.v1i1.888