HORMONE REPLACEMENT THERAPY: PHYTOESTROGEN AND/OR SYNTHETIC DECREASES CLIMACTERIC SYMPTOMS?

Authors

DOI:

https://doi.org/10.47820/recima21.v3i1.1046

Keywords:

aim of this study was to compare synthetic

Abstract

The aim of this study was to compare synthetic hormone replacement therapies with phytoestrogens and their relationship with the signs and symptoms of menopause. The research method was through an integrative review of national and international scientific literature. The search platforms were: Scielo, EbscoHost, Pubmed, Portal Capes and VHL in the last 5 years, from April to May 2021, with the descriptors in health sciences (DeCS): Menopause, Hormonal replacement, phytoestrogen. The initial search resulted in 404 articles, from which 16 articles were selected, which responded to the proposed objective. The results show that synthetic and/or phytoestrogen hormone replacement therapies can be administered to minimize the signs and symptoms of menopause. All hormonal therapy requires a prior assessment of general health status, as well as a history of family illnesses. That done, these are effective treatment options for women to go through this stage of life, avoiding some complications caused by low estrogen.

Downloads

Download data is not yet available.

Author Biographies

Brenda Vargas

 

Universidade Luterana do Brasil (ULBRA)

Ana Maria Pujol Vieira dos Santos

Biologist, Professor of Biomedicine and Physical Education graduation courses and of the Master's in Health Promotion, Human Development and Society at Universidade Luterana do Brasil/Ulbra.

Maria Isabel Morgan Martins

Biologist from the University of Vale do Rio dos Sinos. Prof. Adjunct of the Postgraduate Program in Health Promotion and Human Development and Society at Universidade Luterana do Brasil - ULBRA.

References

ABEDI, P. et al. Effect of fennel vaginal cream on sexual function in postmenopausal women: a double blind randomized controlled trial. J. Med. Life. Romenia, v. 11, n. 1, jan. /Mar. 2018. Disponível em: <​​https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909942/>

COSTA, J. P. L., et al. ​​Randomized double-blind placebo-controlled trial of the effect of Morus nigra L. (black mulberry) leaf powder on symptoms and quality of life among climacteric women, International Journal of Gynecology & Obstetrics. São Paulo, v. 148, n.2, 2019. Disponível em: <https://obgyn.onlinelibrary.wiley.com/doi/abs/10.1002/ijgo.13057>

ESPITIA-DE-LA-HOZ, F. J. Terapia de reemplazo hormonal combinada con testosterona para el tratamiento del trastorno del deseo sexual hipoactivo en mujeres en climaterio. Arch Med. Manizales, v. 20, n.1, 2020. Disponível em: <https://pesquisa.bvsalud.org/portal/resource/pt/biblio-1053232>

FARIA, C. P. F. OLIVEIRA, F. Q. Fitoestrogênios como alternativa na terapia de reposição hormonal no climatério. Revista Brasileira de Ciências da vida. v. 5, n. 1, 2017.​​ Disponível em: <http://jornalold.faculdadecienciasdavida.com.br/index.php/RBCV/article/view/528>

FERREIRA, W. C. et al. Terapia de Reposição hormonal bioidêntica: eficaz e segura?. In Congresso Internacional em Saúde. n. 8, July/2021. Disponível em:

KIM, J. et al. Inhibitory effects of Leonurus sibiricus on weight gain after menopause in ovariectomized and high-fat diet-fed mice. J. Nat. Med. Tokyo, v. 70, n. 3, July/2016.Disponível em: <https://link.springer.com/article/10.1007/s11418-016-0971-7>

KUSHWAHA, P. et al. A neoflavonoid dalsissooal isolated from heartwood of dalbergia sissoo roxb. has bone forming effects in mice model for osteoporosis. Eur. J. Pharmacol. Amsterdam, v. 788, Oct. /2016. Disponível em: <https://europepmc.org/article/med/24803361>

RAHIMIKIAN, F. et al. Effect of Foeniculum vulgare Mill. (fennel) on menopausal symptoms in postmenopausal women: a randomized, triple-blind, placebo-controlled trial. Menopause. New York, v. 24, n. 9, Sept. /2017. Disponível em: <https://www.researchgate.net/publication/316992862_Effect_of_Foeniculum_vulgare_Mill_fennel_on_menopausal_symptoms_in_postmenopausal_women_a_randomized_triple-blind_placebo-controlled_trial>

REL, B. A. R., OLDRA, C. M., FRIGO, M, KOEHNLEIN, E. A. Fatores de risco para doenças cardiovasculares e ingestão dietética em mulheres climatéricas não usuárias de Terapia de Reposição Hormonal (TRH). Rev. Inst Adolfo Lutz. São Paulo, v. 78, 2019. Disponível em: <https://periodicos.saude.sp.gov.br/index.php/RIAL/article/view/35862>

RIBEIRO, E. Efeito da isoflavona associada ou não ao probiótico comparado a terapia hormonal nos sintomas urogenitais da menopausa: ensaio clínico randomizado. UEC, Campinas, 2019. Disponível em: <​​https://bdtd.ibict.br/vufind/Record/CAMP_16e3d2e4cebcc0a6cdcbc423c1c8a42b>

SELBAC, M. T, ​et al.​ ​Mudanças comportamentais e fisiológicas determinadas pelo ciclo biológico feminino – climatério a menopausa. Revista Aletheia. Canoas, vol. 51, n.1-2, dez/2018. Disponível em: <http://pepsic.bvsalud.org/pdf/aletheia/v51n1-2/v51n1-2a16.pdf>

SILVA, B. SIOCHETTA, T. M. BERLEZI, E. M. Medicinal plants used for treatment of menopause-related disorders. rev. Ciências Médicas e Biológicas. Salvador, v. 19, n. 1, jan/abril 2020. Disponível em: <https://repositorio.ufrn.br/bitstream/123456789/33354/1/UsoDePlantas_Pacheco_2021.pdf>

SILVA, M. M. et al., Contemporary evidence on the use of hormonal replacement therapy. v. 2, n. 2, 2019. Disponível em: <https://www.brazilianjournals.com/index.php/BJHR/article/view/1269>

SILVEIRA, A. L. R. et al. Evaluation of the knowledge level about hormonal replacement therapy in the climate of women assisted in an outpatient clinic of a private faculty in Minas Gerais. rev. Interdisciplinar Ciências Médicas. v. 4, n. 2, 2020. Disponível em: <http://revista.fcmmg.br/ojs/index.php/ricm/article/view/424>

SOUZA, M. T. et al. Revisão integrativa: O que é e como Fazer. Eistein. São Paulo, v. 8, n. 2, jan/2010. Disponível em: <https://www.scielo.br/j/eins/a/ZQTBkVJZqcWrTT34cXLjtBx/?format=pdf&lang=pt>

SOUZA, N. R. R. et al. Correlation Between hormonal replacement therapy in the menopause and the development of neoplasms. BJSCR. v. 25, n. 2, dez/2018. Disponível em: <https://www.mastereditora.com.br/periodico/20190103_213618.pdf>

SPRITZER, P. M.; REIS, F. M. Reposição homonal no climatério: Princípios terapêuticos embasados em evidências. Reprod Clim. v. 13, n. 1, 1998. Disponível em: <https://pesquisa.bvsalud.org/portal/resource/pt/lil-216532>

USHA, S. et al. Trends in Prescribing Menopausal Hormone Therapy and Bisphosphonates in Australia and Manitoba, Canada and Adherence to Recommendations. J Womens Heath (Larchmt). v. 29, n. 2, fev/2020. Disponível em: <​​https://pubmed.ncbi.nlm.nih.gov/31895627/>

WADA, T. et al. Impact of central and peripheral estrogen treatment on anxiety and depression phenotypes in a mouse model of postmenopausal obesity. PLoS One., Japão, v. 13, n. 12, 2018. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/30589890/>

ZINGUE, S. et al. Estrogenic effects of Ficus umbellata Vahl. (Moraceae) extracts and their ability to alleviate some menopausal symptoms induced by ovariectomy in Wistar rats. J. Ethnopharmacol. Limerick, v. 179, Feb. / 2016. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/26771069/>

Published

08/01/2022

How to Cite

Vargas, B., Pujol Vieira dos Santos, A. M., & Morgan Martins, M. I. (2022). HORMONE REPLACEMENT THERAPY: PHYTOESTROGEN AND/OR SYNTHETIC DECREASES CLIMACTERIC SYMPTOMS?. RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, 3(1), e311046. https://doi.org/10.47820/recima21.v3i1.1046