HORMONE REPLACEMENT THERAPY IN CLIMACTERIC AND MENOPAUSAL WOMEN AND CARDIOVASCULAR RISK: A SYSTEMATIC REVIEW
DOI:
https://doi.org/10.47820/recima21.v3i10.1949Keywords:
Combined Hormone Replacement Therapy, Climacteric, Menopause, Estrogens, Cardiovascular RiskAbstract
Objective: To verify in the scientific literature the involvement of hormone replacement therapy (HRT) in the development of cardiovascular diseases in menopausal women. Methods: An integrative review was conducted, using as criteria the search in scientific databases PubMed, Scielo and MEDLINE in order to search for papers published in the format of original scientific article, published between the years 2015 and 2021. Results: It was observed that the initiation of hormone replacement therapy, when done close to menopause, tends to have lower cardiovascular health risks when compared to late initiations to the period. Consonant to this, other theses corroborate the idea that, when deprived in the organism, estrogen tends to damage the physiology of the vessel wall, resulting in cardiovascular mortality in the postmenopausal period. On the other hand, besides the ovarian hormone, it is also necessary to evaluate other factors surrounding the menopause morbidity process, such as smoking, obesity, and sedentary lifestyle. Final considerations: Cardioprotective benefits of hormone replacement therapy (HRT) can be seen, depending on the period of life of women.
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