IMUNOGENICIDADE ASSOCIADA AO TRATAMENTO COM TOXINA BOTULÍNICA

Kamila Aquino de Souza; Laura Teixeira Rodrigues da Silva; Gabriel Lima de Freitas

doi:10.47820/recima21.v4i1.4227

Authors

Kamila Aquino de Souza https://orcid.org/0009-0009-3118-3827
Laura Teixeira Rodrigues da Silva https://orcid.org/0009-0000-5452-8634
Gabriel Lima de Freitas

DOI:

https://doi.org/10.47820/recima21.v4i1.4227

Keywords:

Botulinum Toxin, Immunogenicity, Immunoresistance

Abstract

Introduction: Skin aging is an inevitable and natural factor of all human beings. In order to achieve prevention of the signs of aging and improvement of self-esteem, such as smoothing wrinkles and expression lines, aesthetic treatments have been increasing, with treatments based on botulinum toxin being the most sought after worldwide, however, little is addressed about immune resistance and long-term effects. Objective: To discuss the effects of botulinum toxin treatment over the years and the causes of resistance and the "vaccine effect". Method: Literature review work, having as source of research articles published in national and international journals. Discussion: In addition to intrinsic aging, we have to consider the extrinsic, which is related to external factors and the lifestyle of the individual, several factors influence the immunogenicity of botulinum neurotoxins, such as: factors related to the product, the manufacturing process, the antigenic protein load and the presence of accessory proteins, the immune system has cumulative memory and studies show that the formation of antibodies in patients of aesthetic treatments is rare, and those who developed antibodies, received doses of the formulation above the indicated, with an interval of less than one month between injections or else suffered cross-reaction to other antibodies resulting from multiple tetanus vaccines, since the botulinum toxin protein has parts of its structure homologous to the structure produced by Clostridium tetani.

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Author Biographies

Kamila Aquino de Souza

Graduanda do Curso de Biomedicina - Complexo Educacional Faculdade Metropolitanas Unidas (FMU).

Laura Teixeira Rodrigues da Silva

Graduanda do Curso de Biomedicina - Complexo Educacional Faculdade Metropolitanas Unidas (FMU).

Gabriel Lima de Freitas

Biomédico Pós graduado em Cosmetologia e Estética Avançada.

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