AUTOLOGOUS BIOSTIMULATORS: GOOD RESULTS WITH MORE SAFETY
DOI:
https://doi.org/10.47820/recima21.v4i10.4228Keywords:
Platelet-rich Plasma; Facial Rejuvenation; Fibrin Rich in Platelets; Platelet-derived Growth Factor.Abstract
With the advancement of treatments and protocols in the aesthetic universe, the search for collagen biostimulators has been growing exponentially in recent years, consequently to this popularization, there were an increase in the registration of its complications, which opens space for the use of a more natural material, obtaining similar results with much lower risks. In this paperwork, 23 articles that discussed the efficacy of autologous preparations only in aesthetic treatments were considered, bringing together the main products for use in aesthetics. Platelet-Rich Plasma (PRP), obtained from the patient's own blood, has a high concentration of platelets and growth factors, which promotes cell proliferation and differentiation, stimulating hyaluronic acid synthesis and extracellular matrix production, triggering tissue regeneration and improving skin elasticity. From PRP, PRGF (Plasma Ritch in Growth Factors) was developed, a leukocyte-free PRP, which can be customized into high and low density gel with centrifugation and incubation techniques. Platelet Rich Fibrin (PRF) is obtained without the use of additives, unlike the others, in which the collection is done in a tube with the anticoagulant sodium citrate. PRF is obtained in the form of a tense-elastic membrane or in liquid form, called i-PRF. Autologous products show promising results as collagen biostimulators, treating sagging and fine wrinkles and improving the skin's freshness, texture and hydration, but to define standard protocols and results, more studies will still be needed.
Downloads
References
Ribeiro C. Cosmetologia Aplicada a Dermoestética. 1st ed. São paulo: Pharmabooks; 2006.
Fagnani S, Lima AT, Ednigton L, Fernandes P, Dantas M, Nery Benevides A, et al. ENVELHECIMENTO CUTÂNEO. REVISTA DE TRABALHOS ACADÊMICOS-CAMPUS NITERÓI [Internet]. 2013 [cited 2023 Mar 14];0(1). Available from: http://revista.universo.edu.br/index.php?journal=1reta2&page=article&op=viewArticle&path%5B%5D=1464
Dos Santos Silva C, Cezaretti T, Ferreira P. O uso de PRP e PRF em procedimentos estéticos minimizando o envelhecimento cutâneo [Internet]. 2021. Available from: https://repositorio.animaeducacao.com.br/bitstream/ANIMA/22878/1/O%20uso%20do%20PRP%20e%20PRF%20em%20procedimentos%20esteticos%20minimizando%20o%20envelhecimento%20cutaneo.pdf
Leclerc O, Peters N, Scaglione A, Waring J, editors. From extreme to mainstream: The future of aesthetics injectables | McKinsey [Internet]. www.mckinsey.com. McKinsey & Company; 2021. Available from: https://www.mckinsey.com/industries/life-sciences/our-insights/from-extreme-to-mainstream-the-future-of-aesthetics-injectables
Jiménez Gómez N, Pino Castresana A, Segurado Miravalles G, Truchuelo Díez M, Troya Estavillo M, Anitua Aldecoa E, et al. Autologous platelet‐rich gel for facial rejuvenation and wrinkle amelioration: A pilot study. Journal of Cosmetic Dermatology. 2018 Nov 18;18(5):1353–60.
Sanches E, Magalhães M. COMPLICAÇÕES COM BIOESTIMULADORES INJETÁVEIS [Internet]. 2021 Aug. Available from: https://faculdadefacsete.edu.br/monografia/files/original/6e915276cd8f1116a07ed66efe3b465b.pdf
E Silva Neto JM de A, Silva JLV da, Mendonça AJPCD, Duarte IKF, Tenório Neto JF. O uso do ácido hialurônico na harmonização facial: Uma revisão de literatura. Revista Eletrônica Acervo Saúde. 2019 Oct 7;(32):e1269.
Pires YS, Ribeiro PMC. Harmonização Orofacial e o Uso do Ácido Hialurônico e Toxina Botulínica: O Poder de Restituir Autoestima / Orofacial Harmonization and the Use of Hyaluronic Acid and Botulinic Toxin: The Power to Restore Self-Esteem. ID on line REVISTA DE PSICOLOGIA. 2021 Jul 31;15(56):252–60.
Castro MB, Alcântara GA. Efeitos Adversos No Uso Do Ácido Hialurônico Injetável Em Preenchimentos Faciais. Brazilian Journal of Health Review. 2020;3(2):2995–3005.
Woerle B, Hanke CW, Sattler G. Poly-L-lactic acid: a temporary filler for soft tissue augmentation. Journal of drugs in dermatology: JDD [Internet]. 2004;3(4):385–9. Available from: https://pubmed.ncbi.nlm.nih.gov/15303782/
Zerbinati N, D’Este E, Parodi PC, Calligaro A. Microscopic and ultrastructural evidences in human skin following calcium hydroxylapatite filler treatment. Archives of Dermatological Research. 2017 Mar 21;309(5):389–96.
Loghem JV, Yutskovskaya YA, Philip Werschler W. Calcium hydroxylapatite: over a decade of clinical experience. The Journal of Clinical and Aesthetic Dermatology [Internet]. 2015 Jan 1;8(1):38–49. Available from: https://pubmed.ncbi.nlm.nih.gov/25610523/
Faria TR, Júnior JB. Possíveis Intercorrências Causadas Pelo Preenchimento Facial Com Ácido Hialurônico. Conexão Ciência (Online). 2020 Nov 10;15(3):71–83.
Chorążewska M, Piech P, Pietrak J, Kozioł M, Obierzyński P, Maślanko M, et al. The use of platelet-rich plasma in anti-aging therapy (overview). Journal of Education, Health and Sport [Internet]. 2017 Nov 12 [cited 2023 Sep 13];7(11):162–75. Available from: https://apcz.umk.pl/JEHS/article/view/5031
Pinto JMN, Pizani NS. Aplicabilidade em dermatologia do plasma rico em plaquetas. Surgical & Cosmetic Dermatology [Internet]. 2015 [cited 2023 Sep 29];7(1):61–4. Available from: http://www.redalyc.org/articulo.oa?id=265538320015
15 Costa M, Muniz E, De Freitas B. USO DO PLASMA RICO EM PLAQUETAS NO TRATAMENTO DA ALOPECIA ANDROGENÉTICA [Internet]. 2022. Available from: https://repositorio.ufpe.br/bitstream/123456789/48594/1/TCC_Mariana_biomedicina_2022_vers%C3%A3o%20final_com%20ficha%20catalogr%C3%A1fica.pdf
Anitua E, Muruzabal F, Tayebba A, Riestra A, Perez VL, Merayo-Lloves J, et al. Autologous serum and plasma rich in growth factors in ophthalmology: preclinical and clinical studies. Acta Ophthalmologica. 2015 Apr 2;93(8):e605–14.
Giannini S, Cielo A, Bonanome L, Rastelli C, Derla C, Corpaci F, et al. Comparison between PRP, PRGF and PRF: lights and shadows in three similar but different protocols. European Review for Medical and Pharmacological Sciences [Internet]. 2015;19(6):927–30. Available from: https://pubmed.ncbi.nlm.nih.gov/25855914/
Godfrey L, Martínez‐Escribano J, Roo E, Pino A, Anitua E. Plasma rich in growth factor gel as an autologous filler for facial volume restoration. Journal of Cosmetic Dermatology. 2020 Feb 11;19(10):2552–9.
Hassan H, Quinlan DJ, Ghanem A. Injectable platelet‐rich fibrin for facial rejuvenation: A prospective, single‐center study. Journal of Cosmetic Dermatology. 2020 Sep 23;19(12):3213–21
Costa M, Muniz E, De Freitas B. USO DO PLASMA RICO EM PLAQUETAS NO TRATAMENTO DA ALOPECIA ANDROGENÉTICA [Internet]. 2022. Available from: https://repositorio.ufpe.br/bitstream/123456789/48594/1/TCC_Mariana_biomedicina_2022_vers%C3%A3o%20final_com%20ficha%20catalogr%C3%A1fica.pdf
Redaelli A, Romano D, Marcianó A. Face and neck revitalization with platelet-rich plasma (PRP): clinical outcome in a series of 23 consecutively treated patients. J Drugs Dermatol. 2010 May;9(5):466-72. PMID: 20480789.
Díaz-Ley B, Cuevast J, Alonso-Castro L, Calvo MI, Ríos-Buceta L, Orive G, et al. Benefits of plasma rich in growth factors (PRGF) in skin photodamage: Clinical response and histological assessment. Dermatologic Therapy. 2015 Apr 10;28(4):258–63.
Downloads
Published
How to Cite
License
Copyright (c) 2023 RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218
This work is licensed under a Creative Commons Attribution 4.0 International License.
Os direitos autorais dos artigos/resenhas/TCCs publicados pertecem à revista RECIMA21, e seguem o padrão Creative Commons (CC BY 4.0), permitindo a cópia ou reprodução, desde que cite a fonte e respeite os direitos dos autores e contenham menção aos mesmos nos créditos. Toda e qualquer obra publicada na revista, seu conteúdo é de responsabilidade dos autores, cabendo a RECIMA21 apenas ser o veículo de divulgação, seguindo os padrões nacionais e internacionais de publicação.
