MOLECULAR MECHANISMS OF NEURONAL DEGENERATION IN PARKINSON'S DISEASE: A BIBLIOGRAPHICAL REVIEW

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DOI:

https://doi.org/10.47820/recima21.v5i1.4810

Keywords:

Parkinson's Disease, Nerve Degeneration, Signs and Symptoms, Therapeutics

Abstract

Introduction: Parkinson's disease (PD) is one of the most prevalent neurodegenerative conditions worldwide and is characterized by progressive degeneration of nerve cells, especially in the region of the brain known as the substantia nigra. This progressive, chronically debilitating disorder transcends its clinical manifestations, permeating the physical, cognitive and emotional spheres of those who experience its daily challenges. Methodology: This is a bibliographical review, using articles present in the following databases: PubMed, Scopus and SciELO. Original articles and systematic reviews in English and Portuguese published between 2020 and 2024 were included, which addressed Molecular Mechanisms of Neuronal Degeneration in PD. After analysis, 19 articles were selected to prepare this bibliographic review. Results and Discussion: From this review, the main molecular mechanisms associated with PD were presented: Alpha-synuclein Accumulation, Mitochondrial Dysfunctions, Oxidative Stress and Neuroimmune Inflammation.  Conclusion: It is evident that PD is a complex condition, characterized by an intricate interconnection between molecular mechanisms and clinical manifestations.

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Author Biographies

Ana Maria Santos Cardoso

Instituto de Educação Superior do Vale do Parnaíba-IESVAP.

 

Renata Azevedo Dutra Queiroz

IDOMED - Instituto de Educação Médica.

Luana Elisa Lugli

UNESA - Universidade Estácio de Sá.

Bruno Moreira Germano Borges de Oliveira

UNESA - Universidade Estácio de Sá.

Iago Antonio Godoi da Mata Queiroz

UNESA - Universidade Estácio de Sá.

Thiago Gomes Lima

Coautor neste artigo.

Karla Moura

Universidade São Francisco - USF.

Pedro Henrique Aires Bandeira

ITPAC Porto Nacional.

Beatriz Andrade Varella

FAHESP/IESVAP.

Vívian Saeger Pires

FAHESP/IESVAP.

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Published

18/01/2024

How to Cite

Santos Cardoso, A. M., Azevedo Dutra Queiroz , R., Elisa Lugli, L., Moreira Germano Borges de Oliveira, B., Antonio Godoi da Mata Queiroz, I., Gomes Lima, T., … Saeger Pires , V. (2024). MOLECULAR MECHANISMS OF NEURONAL DEGENERATION IN PARKINSON’S DISEASE: A BIBLIOGRAPHICAL REVIEW. RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, 5(1), e514810. https://doi.org/10.47820/recima21.v5i1.4810

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Vol. 5 No. 1 (2024): CLICK HERE TO ACCESS THE ARTICLES

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