CONGENITAL CYTOMEGALOVIROSIS IN A PEDIATRIC PATIENT IMMUNOSUPPRESSED BY HIV VIRUS: A CASE STUDY
DOI:
https://doi.org/10.47820/recima21.v5i10.5707Keywords:
Integrative pediatrics, Communicable diseases, Infectious diseases, Cytomegalovirus infections,Abstract
Cytomegalovirus-CMV is capable of causing infection with a wide range of symptoms. Cytomegalovirus in pregnant women can leave sequelae in the fetus. Objective: To conduct a case study on congenital cytomegalovirus in a pediatric patient immunosuppressed by HIV. Methodology: This is a retrospective, descriptive study with a quantitative approach, with information obtained from secondary data in the medical records. Results: A newborn was admitted and transferred from another health unit with a diagnosis of congenital cytomegalovirus-CMV, confirmed by serology tests, urine PCR showed only hyaline rhinorrhea with no other complaints or symptoms. The real reason for the transfer was the CT result showing brain parenchyma with hypodensity of the white matter, suggestive of acute encephalitis by cytomegalovirus-CM). After evaluation of the tomography report, treatment was started. The newborn developed jaundice and late neonatal sepsis, respiratory distress syndrome and was consequently transferred to the neonatal ICU, where he remained on mechanical ventilation (MV) for 4 days and nasal CPAP for one month. During this period, he was given antibiotic therapy. After two months, the patient returned to the clinical ward bed in good general condition. The patient was discharged home and later, as scheduled, will continue outpatient care. The child apparently had no sequelae after three months of hospitalization. Conclusion: A good clinical evaluation, collection of information about the family history, differential diagnosis and laboratory confirmation can provide answers and improve management.
Downloads
References
Brito SEE, Moreira CAL, et al. Síndrome de mononucleose infecciosa com sorologia positiva para citomegalovírus e Epstein-Barr vírus. Relato de Caso. RP -Residência Pediátrica. 2016;6(1):31–34. http://residenciapediatrica.com.br/detalhes/190/sindrome-de-mononucleose-infecciosa-com-sorologia-positiva-para-citomegalovirus-e-epstein-barr-virus DOI: https://doi.org/10.25060/residpediatr-2016.v6n1-06
Antona D, et al. Seroprevalence of cytomegalovirus infection in France in 2010. Epidemiology and Infection. Epidemiol Infect. 2010;145(7):1471–1478. file:///C:/Users/33822280259/Downloads/seroprevalence-of-cytomegalovirus-infection-in-france-in-2010.pdf DOI: https://doi.org/10.1017/S0950268817000103
De Matos SB. Citomegalovírus: uma revisão da patogenia, epidemiologia e diagnóstico da infecção. Saúde. Com. 2016;7(1). https://periodicos2.uesb.br/index.php/rsc/article/view/193
Goodrum F, Caviness K, Zagallo P. Human Cytomegalovirus Persistence. National Institute of Health. 2013;14(5):644–655. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1462-5822.2012.01774.x DOI: https://doi.org/10.1111/j.1462-5822.2012.01774.x
Junie Liam. Cytomegalovirus infection in immunosuppressed patients after kidney transplantation. Clujul Med. 2013; 89(3):343–346. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990428/ DOI: https://doi.org/10.15386/cjmed-587
Kimberlin DW. et al. Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial. The Journal of Pediatrics. jan. 2017;143(1):16–25. https://pubmed.ncbi.nlm.nih.gov/12915819/ DOI: https://doi.org/10.1016/S0022-3476(03)00192-6
Marin LJ, et al. Prevalence and clinical aspects of CMV congenital Infection in a low-income population. Virology Journal. jan. 2017;1–5. https://pubmed.ncbi.nlm.nih.gov/27581616/ DOI: https://doi.org/10.1186/s12985-016-0604-5
Van Boven M, et al. Infectious reactivation of cytomegalovirus explaining age- and sex-specific patterns of seroprevalence. PLOS Computational Biology. 26 set. 2017;13(9):e1005719. https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005719 DOI: https://doi.org/10.1371/journal.pcbi.1005719
Voigt S, et al. Cytomegalovirus Seroprevalence Among Children and Adolescents in Germany: Data From the German Health Interview and Examination Survey for Children and Adolescents (KiGGS), 2003–2006. Open Forum Infectious Diseases. jan 2016;3(1):ofv193. https://pubmed.ncbi.nlm.nih.gov/26817022/ DOI: https://doi.org/10.1093/ofid/ofv193
Wang C, et al. Cytomegalovirus IgM Seroprevalence among Women of Reproductive Age in the United States. PLOS ONE. 18 mar. 2016;11(3):e0151996. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0151996 DOI: https://doi.org/10.1371/journal.pone.0151996
Jaramillo DCR, Jaramillo MIH. Factores de riesgo y tratamento profiláctico em pacientes pediátricos porinfección de citomegalovírus post transplante renal. Dom. Cien. Abril-Junio 2023;9(3):1913-1932. https://dominiodelasciencias.com/ojs/index.php/es/article/view/3384/7615
Tan MSH, et al. A single-centre observational study comparing the impact of different cytomegalovirus prophylaxis strategies on cytomegalovirus infections in kidney transplant recipients. Proc Singap Healthc. 2021;30(2):117-24. https://journals.sagepub.com/doi/full/10.1177/2010105820953461 DOI: https://doi.org/10.1177/2010105820953461
Krech U, et al. Complement-fixing antibodies against cytomegalovirus in different parts of theworld. Bull World Health Organ. 2020;49(1):103-6. https://pubmed.ncbi.nlm.nih.gov/4363395/
Alfieri CM, et al. Cytomegalovirus Disease in Renal Transplanted Patients: Prevalence, Determining Factors, and Influence on Graftand Patients Outcomes. Pathogens. abrilde 2021;10(4):473. https://pubmed.ncbi.nlm.nih.gov/33919676/ DOI: https://doi.org/10.3390/pathogens10040473
Al Atbee MYN, Tuama HS. Cytomegalovirus infection afterrenal transplantation. J Med Life. enero 2022;15(1):71-7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8852648/ DOI: https://doi.org/10.25122/jml-2021-0209
Sarmiento JFC, et al. Sepsis por citomegalovirus en el paciente pediátrico. Revista Cubana de Pediatría. 2023;95:e3984. http://scielo.sld.cu/pdf/ped/v95/1561-3119-ped-95-e3984.pdf
Chiopris G, Veronese P, Cusenza F, Procaccianti M, Perrone S, Daccò V, et al. Congenital cytomegalovirus infection: Update on diagnosis and treatment. V8. Microorganisms. 2020;8(10):1-17. DOI: https://doi.org/10.3390/microorganisms8101516 DOI: https://doi.org/10.3390/microorganisms8101516
Patel RM, Shenvi N, Knezevic A, Hinkes M, Bugg GW, Stowell SR, et al. Observational study of cytomegalovirus from breast milk and necrotising enterocolitis. Arch Dis Child Fetal Neonatal. 2020;105(3):259-65. DOI: https://doi.org/10.1136/archdischild-2018-316613 DOI: https://doi.org/10.1136/archdischild-2018-316613
Goelz R, Hamprecht K, Klingel K, Poets CF. Intestinal manifestations of postnatal and congenital cytomegalovirus infection in term and preterm infants. J Clin Virol. 2016;83:29-36. DOI: https://doi.org/10.1016/j.jcv.2016.08.289 DOI: https://doi.org/10.1016/j.jcv.2016.08.289
Dipasquale V, Cucinotta U, Romano C. Acute malnutrition in children: Pathophysiology, clinical effects and treatment. Nutrients. 2020;12:8. DOI: https://doi.org/10.3390/nu12082413 DOI: https://doi.org/10.3390/nu12082413
Bourke CD, Jones KDJ, Prendergast AJ. Current Understanding of Innate Immune Cell Dysfunction in Childhood Undernutrition. Front Immunol. 2019;10. DOI: https://doi.org/10.3389/fimmu.2019.01728 DOI: https://doi.org/10.3389/fimmu.2019.01728
Mitsuiki N, Tamanuki K, Sei K, Ito J, Kishi A, Kobayashi K, et al. Severe neonatal CMV infection complicated with thrombotic microangiopathy successfully treated with ganciclovir. J Infect Chemother. 2017;23(2):107-10. DOI: https://doi.org/10.1016/j.jiac.2016.08.007 DOI: https://doi.org/10.1016/j.jiac.2016.08.007
Downloads
Published
How to Cite
License
Copyright (c) 2024 RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218
This work is licensed under a Creative Commons Attribution 4.0 International License.
Os direitos autorais dos artigos/resenhas/TCCs publicados pertecem à revista RECIMA21, e seguem o padrão Creative Commons (CC BY 4.0), permitindo a cópia ou reprodução, desde que cite a fonte e respeite os direitos dos autores e contenham menção aos mesmos nos créditos. Toda e qualquer obra publicada na revista, seu conteúdo é de responsabilidade dos autores, cabendo a RECIMA21 apenas ser o veículo de divulgação, seguindo os padrões nacionais e internacionais de publicação.