EFFICACY OF RETINOIC ACID IN REJUVENATING TREATMENT: A LITERATURE REVIEW
DOI:
https://doi.org/10.47820/recima21.v5i11.5909Keywords:
Rejuvenation. Retinoids. Skin.Abstract
Anti-aging medicine focuses on improving quality of life during aging, considering the influence of environmental factors such as pollution, tobacco, poor diet, stress, and irregular sleep. Anti-aging cosmetic products, especially those containing retinoic acid, have gained attention for their skin rejuvenation properties. Therefore, this article reviews the literature on the efficacy of retinoic acid in treating fine lines and wrinkles, analyzing its mechanisms of action, application protocols, efficacy, safety, and associated side effects. The methodology included a review of articles published between 2019 and 2024 in the PubMed database and the Virtual Health Library. The results indicate that retinoids, particularly retinoic acid, are effective in improving the visible manifestations of skin aging, promoting cell turnover and collagen formation. However, side effects such as irritation and peeling are common, making management strategies essential. Therefore, it is concluded that retinoic acid is a promising option for anti-aging treatment, requiring specific protocols to maximize its efficacy and minimize adverse effects.
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CAMPIONE, E. et al. Clinical efficacy and reflectance confocal microscopy monitoring in moderate‐severe skin aging treated with a polyvinyl gel containing retinoic and glycolic acid: An assessor‐blinded 1‐month study proof‐of‐concept trial. Journal of Cosmetic Dermatology, [s. l.], v. 20, n. 1, p. 310–315, 2021. DOI: https://doi.org/10.1111/jocd.13463
CARAZO, A. et al. Vitamin A Update: Forms, Sources, Kinetics, Detection, Function, Deficiency, Therapeutic Use and Toxicity. Nutrients, [s. l.], v. 13, n. 5, p. 1703, 2021. DOI: https://doi.org/10.3390/nu13051703
COSTA, P. F. da; LOPES, D. A. da C. Cosmecêuticos com ação regeneradora na pele com ativos retinóides. Revista da Saúde da AJES, [s. l.], v. 7, n. 14, 2021.
DEINA, A. et al. O PAPEL DOS ANTIOXIDANTES NA PREVENÇÃO E NO TRATAMENTO DO ENVELHECIMENTO CUTÂNEO. [S. l.: s. n.], s. d
GUERRA, M. N. A.; FONSECA, A. F. S.; SOBRINHO, H. M. R. Uso de Cosmecêuticos no Rejuvenescimento Facial. Revista Educação em Saúde, [s. l.], v. 8, n. 1, p. 219–233, 2020. DOI: https://doi.org/10.29237/2358-9868.2020v8i1.p219-233
HALAI, P. et al. Retinoids in the treatment of photoageing: A histological study of topical retinoid efficacy in black skin. Journal of the European Academy of Dermatology and Venereology, [s. l.], v. 38, n. 8, p. 1618–1627, 2024. DOI: https://doi.org/10.1111/jdv.20043
JOHNER, K.; NETO, C. F. G. Análise dos fatores de risco para o envelhecimento da pele: aspectos nutricionais / Analysis of risk factors for skin aging: nutritional aspects. Brazilian Journal of Health Review, [s. l.], v. 4, n. 3, p. 10000–10018, 2021. DOI: https://doi.org/10.34119/bjhrv4n3-035
MELLODY, K. T. et al. Multifaceted amelioration of cutaneous photoageing by (0.3%) retinol. International Journal of Cosmetic Science, [s. l.], v. 44, n. 6, p. 625–635, 2022. DOI: https://doi.org/10.1111/ics.12799
OLIVEIRA, B. A.; PEREIRA, T. A. Avaliação da frequência de uso do ácido retinóico (tretinoína) em formulações cosméticas em uma farmácia de manipulação da cidade de sacramento – mg para o tratamento do envelhecimento facial. 2019. Trabalho de Conclusão de Curso (Grduação) - Universidade de Uberaba, Uberaba, MG, 2019.
QUAN, T. Human Skin Aging and the Anti-Aging Properties of Retinol. Biomolecules, [s. l.], v. 13, n. 11, p. 1614, 2023. DOI: https://doi.org/10.3390/biom13111614
RAO, S.; GOLDBERG, D. Clinical and histologic findings after use of a novel combined retinol, tripeptide, and glaucine containing cream in the treatment of PHOTO‐AGED skin. Journal of Cosmetic Dermatology, [s. l.], v. 22, n. 10, p. 2765–2768, 2023. DOI: https://doi.org/10.1111/jocd.15945
SADICK, N. et al. An Advanced, Physician-Strength Retinol Peel Improves Signs of Aging and Acne Across a Range of Skin Types Including Melasma and Skin of Color. Journal of Drugs in Dermatology, [s. l.], v. 18, n. 9, 2019.
SHU, P. et al. Efficacy and mechanism of retinyl palmitate against UVB-induced skin photoaging. Frontiers in Pharmacology, [s. l.], v. 14, p. 1278838, 2023. DOI: https://doi.org/10.3389/fphar.2023.1278838
SILVA, A. E. L. D.; GOMES, R. R. C.; ARAÚJO NETO, J. F. D. Análise da atitude do consumidor frente a obtenção de dermocosméticos. Revista Ibero-Americana de Humanidades, Ciências e Educação, [s. l.], v. 7, n. 11, p. 298–313, 2021. DOI: https://doi.org/10.51891/rease.v7i11.3070
SOUZA, F. K. M. D.; MACHADO, K. E. Benefícios da utilização da vitamina A tópica e seus derivados na prevenção do envelhecimento cutâneo /Benefits of the use of vitamin A topical and its derivatives in the prevention of skin aging. ID on line. Revista de psicologia, [s. l.], v. 16, n. 60, p. 702–717, 2022. DOI: https://doi.org/10.14295/idonline.v16i60.3456
SPIERINGS, N. M. K. Evidence for the Efficacy of Over-the- counter Vitamin A Cosmetic Products in the Improvement of Facial Skin Aging. Journal of Clinical and Aesthetic Dermatology, [s. l.], v. 14, n. 9, 2021.
SZYMAŃSKI, Ł. et al. Retinoic Acid and Its Derivatives in Skin. Cells, [s. l.], v. 9, n. 12, p. 2660, 2020. DOI: https://doi.org/10.3390/cells9122660
ZHONG, J. et al. Topical retinoids: Novel derivatives, nano lipid‐based carriers, and combinations to improve chemical instability and skin irritation. Journal of Cosmetic Dermatology, [s. l.], v. 23, n. 10, p. 3102–3115, 2024. DOI: https://doi.org/10.1111/jocd.16415
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