DIFFERENCES BETWEEN TETRAHYDROCANNABIOL AND CANNABIDIOL AND THEIR CLINICAL USES AMONG STUDENTS AT A UNIVERSITY CENTER IN CASCAVEL – PARANÁ
DOI:
https://doi.org/10.47820/recima21.v5i11.5993Keywords:
Cannabis; Cannabidiol; THC; CBD.Abstract
Various studies on Tetrahydrocannabinol (THC) and Cannabidiol (CBD) have revealed a wide range of therapeutic possibilities, with a low incidence of adverse effects. However, their clinical use remains limited. This study aimed to evaluate the perception of Nursing and Pharmacy students regarding the therapeutic properties of CBD and THC. It is a cross-sectional, quantitative, and descriptive study, conducted through an online questionnaire, available on the Google Forms platform. Among the 350 Nursing students, 38 responded to the questionnaire, representing an adhesion rate of 10.86%. In the Pharmacy course, 65 out of 162 students responded, with an adhesion rate of 40.1%. The majority of participants were female (76.7%), with an age range of 19 to 25 years (64.1%). Regarding knowledge of Cannabis compounds, 63.1% of respondents had information about the medicinal use of THC, while 94.2% knew about CBD. Only 1.9% reported having advanced knowledge of the compounds. The most commonly cited treatments were for chronic pain (70.2%) and epilepsy (61.54%). It is hoped that this research will stimulate further investigations on the topic, raising awareness among students and healthcare professionals, especially in fields that can prescribe CBD and THC. The goal is to promote knowledge about the benefits of these substances in the treatment of various conditions, including their use as adjunctive therapy in palliative care and in the management of patients requiring alternative therapies.
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ADAMS, R.; HUNT, M.; CLARK, J. H. Structure of Cannabidiol, a Product Isolated from the Marihuana Extract of Minnesota Wild Hemp. I. Journal of the American Chemical Society, v. 62, n. 1, p. 196–200, jan. 1940. DOI: https://doi.org/10.1021/ja01858a058
AGÊNCIA NACIONAL DE VIGILÂNCIA SANITÁRIA (Brasil). Resolução – RDC n° 17, de 06 de maio de 2015. Define os critérios e os procedimentos para a importação, em caráter de excepcionalidade, de produto à base de Canabidiol em associação com outros canabinóides, por pessoa física, para uso próprio, mediante prescrição de profissional legalmente habilitado, para tratamento de saúde. Disponível em: <http://portal.anvisa.gov.br/wps/wcm/connect/79b8cf8048c1d62783e5bf0a466faa84/RDC+17-2015.pdf?MOD=AJPERES>.
ARKSEY, H.; O’MALLEY, L. Scoping studies: Towards a methodological framework. International Journal of Social Research Methodology Theory and Practice, v. 8, n. 1, p. 19–32, 2005. DOI: https://doi.org/10.1080/1364557032000119616
BAR-LEV SCHLEIDER, L. et al. Real life Experience of Medical Cannabis Treatment in Autism: Analysis of Safety and Efficacy. Scientific Reports, v. 9, n. 1, p. 200, 2019. DOI: https://doi.org/10.1038/s41598-018-37570-y
BRASIL, E. M. Educa Mais Brasil - Bolsas de Estudo de até 70% para Faculdades – Graduação e Pós-graduação. Disponível em: <https://www.educamaisbrasil.com.br/educacao/noticias/mulheres-no-ensino-superior-sao-maioria-entenda>.
CARLINI, E. A. A história da maconha no Brasil. Jornal Brasileiro de Psiquiatria, v. 55, n. 4, p. 314–317, 2006.
CARLINI, E. A. A história da maconha no Brasil. Jornal Brasileiro de Psiquiatria, v. 55, n. 4, Rio de Janeiro, 2006. Disponível em: <http://www.scielo.br/pdf/jbpsiq/v55n4/a08v55n4.pdf>. DOI: https://doi.org/10.1590/S0047-20852006000400008
CORTES, A. Quais doenças podem ser tratadas com o Canabidiol (CBD)? Disponível em: <https://www.remessaonline.com.br/blog/quais-doencas-podem-ser-tratadas-com-o-canabidiol-cbd/>.
COSTA, A. F. Farmacognosia. 3. ed. Lisboa: Editora Coloust Gulbenkian, 1970. v. 1, p. 90-95.
DEVINSKY, O. et al. Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. The Lancet. Neurology, v. 15, n. 3, p. 270-278, 2016. DOI: https://doi.org/10.1016/S1474-4422(15)00379-8
DEL0891. Disponível em: <http://www.planalto.gov.br/ccivil_03/decreto-lei/1937-1946/Del0891.htm>. Acesso em: 9 maio. 2024.
DU TOIT, B. M. Cannabis in Africa: a survey of its distribution in Africa, and a study of cannabis use and users in multi-ethnic South Africa. Rotterdam: Published for the African Studies Center, University of Florida, Gainesville, Florida by A.A. Balkema, 1980. 512 p.
DUVALL, C. Cannabis. Reaktion Books LTDA. Londres, 2014. 264 p.
ELSOHLY, M. A.; SLADE, D. Chemical constituents of marijuana: The complex mixture of natural cannabinoids. Life Sciences, v. 78, n. 5, p. 539–548, dez. 2005. DOI: https://doi.org/10.1016/j.lfs.2005.09.011
EPILEPSIA: conheça a doença e os tratamentos disponíveis no SUS. Disponível em: <https://www.gov.br/saude/pt-br/assuntos/noticias/2022/marco/epilepsia-conheca-a-doenca-e-os-tratamentos-disponiveis-no-sus#:~:text=De%20acordo%20com%20a%20Organiza%C3%A7%C3%A3o>.
FITZGERALD, M. L.; MACKIE, K.; PICKEL, V. M. Ultrastructural localization of cannabinoid-1 (CB1) and mGluR5 receptors in the prefrontal cortex and amygdala. The Journal of Comparative Neurology, v. 527, n. 16, p. 2730–2741, 1 nov. 2019. DOI: https://doi.org/10.1002/cne.24704
GROTENHERMEN, F.; MULLER-VAHL, K. The therapeutic potential of cannabis and cannabinoids. Deutsches Ärzteblatt International, v. 109, n. 29–30, p. 495–501, 2012. DOI: https://doi.org/10.3238/arztebl.2012.0495
HESKETH, P. J. et al. Antiemetics: American Society of Clinical Oncology clinical practice guideline update. Journal of Clinical Oncology, v. 35, p. 3240–61, 2017. DOI: https://doi.org/10.1200/JCO.2017.74.4789
HONÓRIO, K. M.; ARROIO, A.; SILVA, A. B. F. DA. Aspectos terapêuticos de compostos da planta *Cannabis sativa*. Química Nova, v. 29, n. 2, p. 318–325, abr. 2006. DOI: https://doi.org/10.1590/S0100-40422006000200024
HUNTSMAN, R. J. et al. Dosage related efficacy and tolerability of cannabidiol in children with Treatment-Resistant Epileptic Encephalopathy: Preliminary Results of the CARE-E Study. Frontiers in Neurology, v. 10, p. 716, 2019. DOI: https://doi.org/10.3389/fneur.2019.00716
JR, C. V.; FRANCO, G. DOS R. R. A contribuição de estudos do canabidiol e análogos sintéticos no desenho de novos candidatos a fármacos contra transtornos neuropsiquiátricos e doenças neurodegenerativas. Revista Virtual de Química, v. 9, n. 4, 8 set. 2017.
LESSA, M. A.; CAVALCANTI, I. L.; FIGUEIREDO, N. V. Cannabinoid derivatives and the pharmacological management of pain. Revista Dor, v. 17, n. 1, p. 47-51, 2016. DOI: https://doi.org/10.5935/1806-0013.20160012
LIMA, A. A. DE; ALEXANDRE, U. C.; SANTOS, J. S. O uso da maconha (*Cannabis sativa* L.) na indústria farmacêutica: uma revisão. Research, Society and Development, v. 10, n. 12, p. e46101219829, 13 set. 2021. DOI: https://doi.org/10.33448/rsd-v10i12.19829
MECHOULAM, R., organizador. Cannabinoids as Therapeutic Agents [Internet]. 1. ed. Chapman and Hall/CRC, 2019. Disponível em: <https://www.taylorfrancis.com/books/9780429522796>. DOI: https://doi.org/10.1201/9780429260667
MECHOULAM, R. et al. Chemical Basis of Hashish Activity. Science, v. 169, n. 3945, p. 611–612, 7 ago. 1970. DOI: https://doi.org/10.1126/science.169.3945.611
NAHAS, G. G. A maconha ou a vida. Rio de Janeiro: Nórdica, 1986.
NERI, M.; NASCIMENTO, C.; GONÇALVEZ, R.; NORONHA, T. Entre a ciência e a insegurança. Revista do Farmacêutico, v. 135, n. 1, p. 32-39, 2018.
PDQ Integrative, Alternative and CTEB. Cannabis and Cannabinoids (PDQ®): Health Professional Version. PDQ Cancer Information Summaries, 2002.
REN, G. et al. Large-scale whole-genome resequencing unravels the domestication history of Cannabis sativa. Science Advances, v. 7, n. 29, p. eabg2286, 2021. DOI: https://doi.org/10.1126/sciadv.abg2286
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