ACTIVIDADES FARMACOLÓGICAS DE LA BERGININA Y DERIVADOS: UNA REVISIÓN SISTEMÁTICA
DOI:
https://doi.org/10.47820/recima21.v4i1.2615Palabras clave:
Bergenina, actividad farmacológica, síntesis, antiinflamatorio, antioxidanteResumen
La bergenina es un C-glucósido del ácido 4-O-metil-conálico, caracterizado como un polifenol cristalino e incoloro. Se ha informado que se ha aislado de plantas medicinales como Flueggea leucopyrus, Bergenia crassifolia, Mallotus philippensis, Corylopsis spicata, Caesalpinia digyna, Mallotus japonicus y Sacoglottis gabonensis. En la región amazónica específicamente la bergenina está catalogada como uno de los principales compuestos bioactivos presentes en la especie Endopleura uchi, conocida popularmente como uchi amarillo. Es una sustancia que tiene múltiples propiedades farmacológicas como antiinflamatoria, antitumoral, citoprotectora, antiarrítmica, antimicrobiana, antidiabética, entre otras. A través de una encuesta bibliográfica en las bases de datos PubMed y Science Direct, entre 2016 y 2022, utilizando los descriptores "bergenina", "actividad farmacológica", "síntesis" y "antioxidante", tras la aplicación de los criterios de inclusión y exclusión, se evaluaron un total de 35 artículos sobre bergenina y derivados. Los resultados mostraron que las propiedades farmacológicas más recurrentes atribuidas a la bergenina fueron las relacionadas con las actividades antiinflamatorias (8 publicaciones), seguidas de la actividad antitumoral (5 publicaciones), citoprotección (5 publicaciones), acción sobre el metabolismo óseo (3 publicaciones), inmunomoduladora (3 publicaciones), antiparasitaria (2 publicaciones) y antioxidante (2 publicaciones). De los 35 artículos estudiados, seis fueron producciones relacionadas con derivados de bergenina, que estudiaron propiedades antiinflamatorias y antitumorales. Esta revisión presenta una investigación bibliográfica exhaustiva de diferentes estudios y proporciona información sobre el potencial de la bergenina y sus derivados para el uso y desarrollo de nuevos fármacos.
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