EFEITO DE GENGIBRE (ZINGIBER OFFICINALE) NO PERFIL LIPÍDICO E GLICEMICO EM INDIVÍDUOS COM DIABETES MELLITUS TIPO 2: REVISÃO NARRATIVA

Autores

DOI:

https://doi.org/10.47820/recima21.v3i6.1548

Palavras-chave:

Gengibre; gengibre officinale; Diabetes mellitus do tipo 2.

Resumo

A diabetes mellitus do tipo 2 é uma doença crónica caracterizada por hiperglicemia e, frequentemente, acompanhada de dislipidemia, hipertensão e disfunção endotelial que constitui factor de risco para doenças cardiovasculares. A sua prevalência aumentou a nível global, se constitui em um sério problema de saúde pública, tanto em países desenvolvidos como nos países em desenvolvimento. A presente revisão tem como objectivo avaliar o efeito do gengibre (zingiber officinale) no perfil glicemico e lipídico em indivíduos com Diabetes mellitus do tipo 2. Trata-se de uma revisão narrativa em que foram consultadas três bases de dados nomeadamente a Pubmed, Scielo e Google Escolar. Quanto aos critérios de inclusão foram incluidos ensaios clinicos randomizados que avaliaram o efeito da suplementação de gengibre na diabetes mellitus do tipo 2. Resultados de ensaios clínicos suportam evidências do efeito do gengibre no controlo da insulina, glicemia, hemoglobina glicada, HOMA-IR, colesterol total, LDL-c, Trigliceridos em indivíduos com diabtes mellitus do tipo2. Os mecanismos continuam em estudo, acredita-se que o gengibre inibe a actividade das enzimas digestivas α-amilase e α-glucosidase.

 

 

 

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Biografia do Autor

  • Lote Manuel

    Instituto Superior Politécnico da CAÁLA - ISPCAÁLA

  • António Ribeiro Chissululo Chissoca

    Universidade José Eduardo dos Santos

  • Arlindo da Costa Afonso

    Instituto Superior Politécnico da CAÁLA - ISPCAÁLA

  • Armindo Paixão António

    Universidade José Eduardo dos Santos

Referências

Abdulrazak A, Tanko Y, Mohammed A, Mohammed KA, Sada NM, Dikko AA. Effects of Clove and Fermented Ginger on Blood Glucose, Leptin, Insulin and Insulin Receptor Levels in High Fat DietInduced Type 2 Diabetic Rabbits. Niger J Physiol Sci. 2018;33(1):89-93.

Akhani SP, Vishwakarma SL, Goyal RK. Anti-diabetic activity of Zingiberofficinale in streptozotocin-induced type I diabetic rats.J Pharm Pharmacol. 2004;56(1):101-5.

Al-Amin ZM, Thomson M, Al-Qattan KK, Peltonen-Shalaby R, Ali M. Anti-diabetic and hypolipidaemic properties of ginger (Zingiberofficinale) in streptozotocin-induced diabetic rats. Br J Nutr. 2006;96(4):660-6.

Al-Noory AS, Amreen AN, Hymoor S. Antihyperlipidemic effects of ginger extracts in alloxan-induced diabetes and propylthiouracil-induced hypothyroidism in (rats). Pharmacognosy Res. 2013;5(3):157-61.

Alam F, Shafique Z, Amjad ST, Bin Asad MHH. Enzymes inhibitors from natural sources with antidiabetic activity: A review. Phytother Res. 2019;33(1):41-54.

Alizadeh-Navaei R, Roozbeh F, Saravi M, Pouramir M, Jalali F, Moghadamnia AA. Investigation of the effect of ginger on the lipid levels. A double blind controlled clinical trial. Saudi Med J. 2008;29(9):1280-4.

Arablou T, Aryaeian N, Valizadeh M, Sharifi F, Hosseini A, Djalali M. The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus.Int J Food SciNutr. 2014;65(4):515-20.

Azimi P, Ghiasvand R, Feizi A, Hariri M, Abbasi B. Effects of Cinnamon, Cardamom, Saffron, and Ginger Consumption on Markers of Glycemic Control, Lipid Profile, Oxidative Stress, and Inflammation in Type 2 Diabetes Patients. Rev Diabet Stud. 2014;11(3-4):258-66.

Iranloye BO, Arikawe AP, Rotimi G, Sogbade AO. Anti-diabetic and anti-oxidant effects of Zingiberofficinale on alloxan-induced and insulin-resistant diabetic male rats. Niger J Physiol Sci. 2011;26(1):89-96.

Khandouzi N, Shidfar F, Rajab A, Rahideh T, Hosseini P, Mir Taheri M. The effects of ginger on fasting blood sugar, hemoglobin a1c, apolipoprotein B, apolipoprotein a-I and malondialdehyde in type 2 diabetic patients. Iran J Pharm Res. 2015;14(1):131-40.

Li Y, Tran VH, Kota BP, Nammi S, Duke CC, Roufogalis BD. Preventative effect of Zingiberofficinale on insulin resistance in a high-fat high-carbohydrate diet-fed rat model and its mechanism of action. Basic ClinPharmacolToxicol. 2014;115(2):209-15.

Mahluji S, Attari VE, Mobasseri M, Payahoo L, Ostadrahimi A, Golzari SE. Effects of ginger (Zingiberofficinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients. Int J Food SciNutr. 2013;64(6):682-6.

Mozaffari-Khosravi H, Talaei B, Jalali BA, Najarzadeh A, Mozayan MR. The effect of ginger powder supplementation on insulin resistance and glycemic indices in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Complement Ther Med. 2014;22(1):9-16.

Shidfar F, Rajab A, Rahideh T, Khandouzi N, Hosseini S, Shidfar S. The effect of ginger (Zingiberofficinale) on glycemic markers in patients with type 2 diabetes. J Complement Integr Med. 2015;12(2):165-70.

Wei CK, Tsai YH, Korinek M, Hung PH, El-Shazly M, Cheng YB, et al. 6-Paradol and 6-Shogaol, the Pungent Compounds of Ginger, Promote Glucose Utilization in Adipocytes and Myotubes, and 6-Paradol Reduces Blood Glucose in High-Fat Diet-Fed Mice. Int J Mol Sci. 2017;18(1).

Zhu J,Chen H, Song Z,Wang Z, Sun Z. Effects of Ginger (Zingiber officinale Roscoe) on Type 2Diabetes Mellitus and Components of the MetabolicSyndrome:A Systematic Review and Meta-Analysis of RandomizedControlled Trials. Evidence-Based Complementary and Alternative Medicine. 2018:1- 11.

Dhanik J, Arya N, Nand V. A Review on Zingiber officinale. Journal of Pharmacognosy and Phytochemistry 2017; 6(3): 174-184

de Lima A, Silva LS , Cavalcante, NAA,Campos TFGM. GENGIBRE (ZINGIBER OFFICINALE ROSCOE), PROPRIEDADESBIOATIVAS E SEU POSSÍVEL EFEITO NO DIABETES TIPO 2: ESTUDO DEREVISÃO. Rev. Saúde em Foco, Teresina, 2014 1,( 2): 15-25

Radwan Al Ali RA, Fawaz Mzayek F, Samer Rastam S, Fouad FM, O’Flaherty M4, Simon Capewell S et al Forecasting future prevalence of type 2 diabetesmellitus in Syria BMC Public Health 2013, 13:507

Nordström A, Hadrévi J, Olsson T, Franks PW, Nordström P. Higher Prevalence of Type 2 Diabetes in Men Thanin Women Is Associated With Differences inVisceral Fat MassJ Clin Endocrinol Metab, October 2016, 101(10):3740–3746

Demmer RT, Zuk AM, Rosenbaum M, Desvarieux M. Prevalence of Diagnosed and Undiagnosed Type 2 Diabetes Mellitus Among USAdolescents: Results From the Continuous NHANES, 1999–2010Am J Epidemiol. 2013;178(7):1106–1113

Diabetes https://www.who.int/es/news-room/fact-sheets/detail/diabetes data de acesso: 5 de outrubro de 2020.

Gengibre https://www.healthbenefitstimes.com/ginger/data de acesso 03 d3 outubro de 2020

Arzati MM, Honarvar NM, Saedisomeolia A, Anvari S,Effatpanah M, Arzat RM et al. The Effects of Ginger on Fasting Blood Sugar, Hemoglobin A1c, and Lipid Profiles in Patients with Type 2 Diabetes. Int J Endocrinol Metab. 2017 October; 15(4):e57927

Azizidoost S , Nazeri Z , Mohammadi A , Mohammadzadeh G , Cheraghzadeh M 1 , Jafari A et al.Effect of Hydroalcoholic Ginger Extract on Brain HMG-CoA Reductase and CYP46A1 Levels in Streptozotocin-induced Diabetic Rats. Avicenna Journal of Medical Biotechnology. 2019;11(3) 234-238.

Rahimlou M, Yari Z , Rayyani E, Keshavarz SA, Hosseini S, Morshedzadeh N , Hekmatdoost, A.Effects of ginger supplementation on anthropometric,glycemic and metabolic parameters in subjects with metabolicsyndrome: A randomized, double-blind, placebo-controlled study. Journal of Diabetes & Metabolic Disorders.2019,1;1-8.

Publicado

18/06/2022

Como Citar

EFEITO DE GENGIBRE (ZINGIBER OFFICINALE) NO PERFIL LIPÍDICO E GLICEMICO EM INDIVÍDUOS COM DIABETES MELLITUS TIPO 2: REVISÃO NARRATIVA. (2022). RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, 3(6), e361548. https://doi.org/10.47820/recima21.v3i6.1548