INTERAÇÃO DO INFLAMASSOMA COM AS DOENÇAS RESPIRATÓRIAS
DOI:
https://doi.org/10.47820/recima21.v4i1.2632Palavras-chave:
Inflamassoma., Asma., DPOC., Câncer de pulmão., Tuberculose., Covid-19.Resumo
Introdução: O inflamassoma é um complexo multiproteico formado no citosol que apresenta como função gerar as formas ativas das citocinas IL-1β e IL-18 que irão promover a resposta inflamatória no indivíduo. A ativação do inflamassoma tem como consequência a piroptose, uma forma inflamatória de morte celular programada de macrófagos caracterizada pelo inchaço das células, perda da integridade da membrana plasmática e liberação de citocinas pró-inflamatórias (IL-1β, IL-18, TNF-α, IL-6 e IL-8). Assim, a participação do inflamassoma está confirmada na patogênese de várias doenças inflamatórias, cuja atuação é moldada pelo tipo de ativação e assim criando um perfil patogênico diferente para cada doença. Objetivo: Dessa forma, este estudo buscou abordar a relação da ativação do inflamassoma na patogênese das doenças do trato respiratório. Metodologia: Trata-se de uma revisão de literatura realizada a partir da análise de periódicos provenientes da plataforma acadêmica: Center for Biotechnology Information (PubMed). A pesquisa foi delimitada em um intervalo de 2001 a 2021, usando as palavras-chaves: Inflamassoma; Asma; DPOC; Infecção trato inferior; Câncer de pulmão; Tuberculose; COVID-19. Desenvolvimento: Os resultados obtidos nos estudos demonstraram que há uma influência do inflamassoma nas patogêneses do trato respiratório. Conclusão: Com base nas informações obtidas, foi possível observar a importância do inflamassoma no desenvolvimento da patogênese de algumas doenças do trato respiratório como a asma, doença pulmonar obstrutiva crônica (DPOC), infecções agudas do trato respiratório inferior, câncer de pulmão, tuberculose e COVID-19.
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