USE OF PROCALCITONIN AS A BIOMARKER FOR ANTIBIOTICOTHERAPY DECISION
DOI:
https://doi.org/10.47820/recima21.v4i12.4543Keywords:
Biomarker. Infection. Antibiotic therapy.Abstract
Introduction: Procalcitonin (PCT), a protein composed of 116 amino acids, is the precursor peptide of the hormone calcitonin. In 2017, the Food and Drug Administration (FDA) approved PCT in the USA as a biomarker for the management of antimicrobial therapy, to assist in the decision to start or stop the use of antibiotics in patients with infections. Objectives: to evaluate whether procalcitonin is effective and safe to assist in decision-making about the need for antibiotic therapy and/or its duration in infectious conditions. Materials and methods: this is an integrative review, in which the guiding question was “Is procalcitonin effective in helping to decide whether or not to use antibiotics and also to escalate/de-escalate antibiotics in bacterial infections?”. The search for articles took place in the PubMed database using the terms “procalcitonin”, “antibiotic”, “therapy” and “decision”, combined with each other using the Boolean operator AND. Results and discussion: PCT improves the management of patients with lower respiratory tract infections and critically ill patients with sepsis, as well as patients with UTIs, postoperative infections, meningitis, and acute heart failure with possible superinfection. Conclusion: Procalcitonin has been shown to be safe and improve clinical outcomes while reducing antibiotic exposure.
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