VITAMIN B12 DEFICIENC IN PATIENTS WITH TYPE 2 DIABETES MELLITUS USING METFORMIN
DOI:
https://doi.org/10.47820/recima21.v5i10.5724Keywords:
Vitamin B12; Metformin; Diabetes.Abstract
Long-term use of metformin, a common treatment for T2DM, is associated with vitamin B12 deficiency, requiring regular monitoring of vitamin levels in treated patients. Material and Methods: This is an integrative review of the literature on metformin-induced vitamin B12 deficiency in patients with type 2 diabetes, using PubMed articles from 2019 to 2024, with strict inclusion and exclusion criteria. Results and Discussion: Metformin is associated with vitamin B12 deficiency, impacting intestinal absorption of the vitamin, which can lead to complications such as neuropathy and anemia. Studies show that prolonged and high-dose use increases the risk of B12 deficiency in patients with type 2 diabetes. Conclusion: Metformin use is related to vitamin B12 deficiency, affecting vitamin absorption and causing complications such as neuropathy and anemia in patients with type 2 diabetes, especially in high doses and prolonged treatments.
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AHMED, Marwan A. et al. Perspectives on peripheral neuropathy as a consequence of metformin-induced vitamin B12 deficiency in T2DM. International Journal of Endocrinology, v. 2017, 2017. DOI: https://doi.org/10.1155/2017/2452853
AL QURAN, Thekraiat et al. Prevalence of vitamin B12 deficiency in type 2 diabetic patients taking metformin, a cross-sectional study in primary healthcare. Frontiers in Endocrinology, v. 14, p. 1226798, 2023. DOI: https://doi.org/10.3389/fendo.2023.1226798
AL SAEED, Roqaih R.; BARAJA, Muneera A. Vitamin B12 deficiency in patients with type 2 diabetes mellitus using metformin and the associated factors in Saudi Arabia. Saudi medical journal, v. 42, n. 2, p. 161, 2021. DOI: https://doi.org/10.15537/smj.2021.2.25693
AL-FAWAEIR, Saad; AL-ODAT, Ibrahim. Influence of metformin intake on serum vitamin B12 levels in patients with type 2 diabetes mellitus. Plos one, v. 17, n. 12, p. e0279740, 2022. DOI: https://doi.org/10.1371/journal.pone.0279740
ALHAJI, Jwaher Haji. Vitamin B12 deficiency in patients with diabetes on metformin: Arab countries. Nutrients, v. 14, n. 10, p. 2046, 2022. DOI: https://doi.org/10.3390/nu14102046
AL-HAMDI, Ahmed et al. Vitamin B12 deficiency in diabetic patients on metformin therapy: a cross-sectional study from Oman. Sultan Qaboos University Medical Journal, v. 20, n. 1, p. e90, 2020. DOI: https://doi.org/10.18295/squmj.2020.20.01.013
ALVAREZ, Mauricio et al. Vitamin B12 deficiency and diabetic neuropathy in patients taking metformin: a cross-sectional study. Endocrine connections, v. 8, n. 10, p. 1324-1329, 2019. DOI: https://doi.org/10.1530/EC-19-0382
BAIG, Fraz Ahmed; KHAN, Saad; RIZWAN, Amber. Frequency of vitamin B12 deficiency in type 2 diabetic patients taking metformin. Cureus, v. 14, n. 3, 2022. DOI: https://doi.org/10.7759/cureus.22924
DE SOUSA, Luís Manuel Mota et al. A metodologia de revisão integrativa da literatura em enfermagem. Revista investigação em enfermagem, v. 21, n. 2, p. 17-26, 2017.
ERCOLE, Flávia Falci; MELO, Laís Samara de; ALCOFORADO, Carla Lúcia Goulart Constant. Revisão integrativa versus revisão sistemática. Reme: Revista Mineira de Enfermagem, v. 18, n. 1, p. 09-11, 2014. DOI: https://doi.org/10.5935/1415-2762.20140001
FITURI, Sundus; AKBAR, Zoha; GANJI, Vijay. Impact of metformin treatment on cobalamin status in persons with type 2 diabetes. Nutrition Reviews, v. 82, n. 4, p. 553-560, 2024. DOI: https://doi.org/10.1093/nutrit/nuad045
GAO, Leili et al. The effects of daily dose and treatment duration of metformin on the prevalence of vitamin B12 deficiency and peripheral neuropathy in Chinese patients with type 2 diabetes mellitus: A multicenter cross-sectional study. Journal of diabetes, v. 15, n. 9, p. 765-776, 2023. DOI: https://doi.org/10.1111/1753-0407.13428
GREEN, Ralph et al. Vitamin B12 deficiency. Nature reviews Disease primers, v. 3, n. 1, p. 1-20, 2017. DOI: https://doi.org/10.1038/nrdp.2017.40
HURLEY-KIM, Keri et al. Effect of metformin use on vitamin B12 deficiency over time (EMBER): a real-world evidence database study. Endocrine Practice, v. 29, n. 11, p. 862-867, 2023. DOI: https://doi.org/10.1016/j.eprac.2023.06.013
HUYNH, Dat Tan; NGUYEN, Ngoc Thi; DO, Minh Duc. Vitamin B12 deficiency in diabetic patients treated with metformin: A cross-sectional study. Plos one, v. 19, n. 4, 2024. DOI: https://doi.org/10.1371/journal.pone.0302500
INFANTE, Marco et al. Long-term metformin therapy and vitamin B12 deficiency: an association to bear in mind. World journal of diabetes, v. 12, n. 7, p. 916, 2021. DOI: https://doi.org/10.4239/wjd.v12.i7.916
KAKARLAPUDI, Yasitha et al. Effect of metformin on vitamin B12 deficiency in patients with type 2 diabetes mellitus and factors associated with it: a meta-analysis. Cureus, v. 14, n. 12, 2022. DOI: https://doi.org/10.7759/cureus.32277
MENDES, Karina Dal Sasso; SILVEIRA, Renata Cristina de Campos Pereira; GALVÃO, Cristina Maria. Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto & contexto-enfermagem, v. 17, p. 758-764, 2008. DOI: https://doi.org/10.1590/S0104-07072008000400018
MIYAN, Zahid; WARIS, Nazish. Association of vitamin B12 deficiency in people with type 2 diabetes on metformin and without metformin: a multicenter study, Karachi, Pakistan. BMJ Open Diabetes Research and Care, v. 8, n. 1, p. e001151, 2020. DOI: https://doi.org/10.1136/bmjdrc-2019-001151
PYRGIOTI, Elisavet E.; KARAKOUSIS, Nikolaos D. B12 levels and frailty syndrome. Journal of Frailty, Sarcopenia and Falls, v. 7, n. 1, p. 32, 2022. DOI: https://doi.org/10.22540/JFSF-07-032
ROJBI, Imen et al. Vitamin B12 levels in type 2 diabetic patients on Metformin compared to those never on Metformin: a cross sectional study in Tunisia. La Tunisie Medicale, v. 101, n. 4, p. 433-439, 2023.
SAYEDALI, Ehsan; YALIN, Ali Erdinç; YALIN, Serap. Association between metformin and vitamin B12 deficiency in patients with type 2 diabetes. World journal of diabetes, v. 14, n. 5, p. 585, 2023. DOI: https://doi.org/10.4239/wjd.v14.i5.585
SUGAWARA, Kenji et al. Relationship between metformin use and vitamin B12 status in patients with type 2 diabetes in Japan. Journal of diabetes investigation, v. 11, n. 4, p. 917-922, 2020. DOI: https://doi.org/10.1111/jdi.13200
THEWJITCHAROEN, Yotsapon et al. Metformin-Associated Vitamin B12 Deficiency: An Underrecognized Complication. JCEM Case Reports, v. 2, n. 4, p. luae029, 2024. DOI: https://doi.org/10.1210/jcemcr/luae029
TIWARI, Aakriti et al. Metformin-Induced Vitamin B12 Deficiency in Patients With Type-2 Diabetes Mellitus. Cureus, v. 15, n. 10, 2023. DOI: https://doi.org/10.7759/cureus.47771
TOMKIN, G. H. et al. Vitamin-B12 status of patients on long-term metformin therapy. Br Med J, v. 2, n. 5763, p. 685-687, 1971. DOI: https://doi.org/10.1136/bmj.2.5763.685
TORREZ, Mary et al. How I investigate acquired megaloblastic anemia. International journal of laboratory hematology, v. 44, n. 2, p. 236-247, 2022. DOI: https://doi.org/10.1111/ijlh.13789
WOLFFENBUTTEL, Bruce HR et al. The many faces of cobalamin (vitamin B12) deficiency. Mayo clinic proceedings: innovations, quality & outcomes, v. 3, n. 2, p. 200-214, 2019. DOI: https://doi.org/10.1016/j.mayocpiqo.2019.03.002
YADAV, Anil et al. Vitamin B12 Deficiency among Metformin Treated Type 2 Diabetic Mellitus Patients Visiting the Department of Medicine of a Tertiary Care Centre. JNMA: Journal of the Nepal Medical Association, v. 61, n. 267, p. 861, 2023. DOI: https://doi.org/10.31729/jnma.8340
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