EFFECT OF GINGER (ZINGIBER OFFICINALE) ON LIPID AND GLYCEMIC PROFILE IN INDIVIDUALS WITH TYPE 2 DIABETES MELLITUS: NARRATIVE REVIEW
DOI:
https://doi.org/10.47820/recima21.v3i6.1548Keywords:
diabetes mellitus is a chronic diseaseAbstract
Type 2 diabetes mellitus is a chronic disease characterized by hyperglycemia, and often accompanied by dyslipidemia, hypertension and endothelial dysfunction, which is a risk factor for cardiovascular diseases. Its prevalence has increased globally; it is a serious public health problem in both developed and developing countries. This review aims to assess the effect of ginger (zingiber officinale) on the glycemic and lipid profile in individuals with type 2 Diabetes mellitus. It is a narrative review in which three databases were consulted, namely Pubmed, Scielo and Google Escolar. As for the inclusion criteria, randomized clinical trials that evaluated the effect of ginger supplementation on type 2 diabetes mellitus were included. Results from clinical trials support evidence of the effect of ginger on insulin, glycaemia, glycated hemoglobin, HOMA-IR, cholesterol control total, LDL-c, triglycerides in individuals with type 2 diabetes mellitus. The mechanisms are still being studied; it is believed that ginger inhibits the activity of digestive enzymes α-amylase and α-glucosidase.
Keywords: Ginger; ginger officinale; Type 2 diabetes mellitus.
Downloads
References
Abdulrazak A, Tanko Y, Mohammed A, Mohammed KA, Sada NM, Dikko AA. Effects of Clove and Fermented Ginger on Blood Glucose, Leptin, Insulin and Insulin Receptor Levels in High Fat DietInduced Type 2 Diabetic Rabbits. Niger J Physiol Sci. 2018;33(1):89-93.
Akhani SP, Vishwakarma SL, Goyal RK. Anti-diabetic activity of Zingiberofficinale in streptozotocin-induced type I diabetic rats.J Pharm Pharmacol. 2004;56(1):101-5.
Al-Amin ZM, Thomson M, Al-Qattan KK, Peltonen-Shalaby R, Ali M. Anti-diabetic and hypolipidaemic properties of ginger (Zingiberofficinale) in streptozotocin-induced diabetic rats. Br J Nutr. 2006;96(4):660-6.
Al-Noory AS, Amreen AN, Hymoor S. Antihyperlipidemic effects of ginger extracts in alloxan-induced diabetes and propylthiouracil-induced hypothyroidism in (rats). Pharmacognosy Res. 2013;5(3):157-61.
Alam F, Shafique Z, Amjad ST, Bin Asad MHH. Enzymes inhibitors from natural sources with antidiabetic activity: A review. Phytother Res. 2019;33(1):41-54.
Alizadeh-Navaei R, Roozbeh F, Saravi M, Pouramir M, Jalali F, Moghadamnia AA. Investigation of the effect of ginger on the lipid levels. A double blind controlled clinical trial. Saudi Med J. 2008;29(9):1280-4.
Arablou T, Aryaeian N, Valizadeh M, Sharifi F, Hosseini A, Djalali M. The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus.Int J Food SciNutr. 2014;65(4):515-20.
Azimi P, Ghiasvand R, Feizi A, Hariri M, Abbasi B. Effects of Cinnamon, Cardamom, Saffron, and Ginger Consumption on Markers of Glycemic Control, Lipid Profile, Oxidative Stress, and Inflammation in Type 2 Diabetes Patients. Rev Diabet Stud. 2014;11(3-4):258-66.
Iranloye BO, Arikawe AP, Rotimi G, Sogbade AO. Anti-diabetic and anti-oxidant effects of Zingiberofficinale on alloxan-induced and insulin-resistant diabetic male rats. Niger J Physiol Sci. 2011;26(1):89-96.
Khandouzi N, Shidfar F, Rajab A, Rahideh T, Hosseini P, Mir Taheri M. The effects of ginger on fasting blood sugar, hemoglobin a1c, apolipoprotein B, apolipoprotein a-I and malondialdehyde in type 2 diabetic patients. Iran J Pharm Res. 2015;14(1):131-40.
Li Y, Tran VH, Kota BP, Nammi S, Duke CC, Roufogalis BD. Preventative effect of Zingiberofficinale on insulin resistance in a high-fat high-carbohydrate diet-fed rat model and its mechanism of action. Basic ClinPharmacolToxicol. 2014;115(2):209-15.
Mahluji S, Attari VE, Mobasseri M, Payahoo L, Ostadrahimi A, Golzari SE. Effects of ginger (Zingiberofficinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients. Int J Food SciNutr. 2013;64(6):682-6.
Mozaffari-Khosravi H, Talaei B, Jalali BA, Najarzadeh A, Mozayan MR. The effect of ginger powder supplementation on insulin resistance and glycemic indices in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Complement Ther Med. 2014;22(1):9-16.
Shidfar F, Rajab A, Rahideh T, Khandouzi N, Hosseini S, Shidfar S. The effect of ginger (Zingiberofficinale) on glycemic markers in patients with type 2 diabetes. J Complement Integr Med. 2015;12(2):165-70.
Wei CK, Tsai YH, Korinek M, Hung PH, El-Shazly M, Cheng YB, et al. 6-Paradol and 6-Shogaol, the Pungent Compounds of Ginger, Promote Glucose Utilization in Adipocytes and Myotubes, and 6-Paradol Reduces Blood Glucose in High-Fat Diet-Fed Mice. Int J Mol Sci. 2017;18(1).
Zhu J,Chen H, Song Z,Wang Z, Sun Z. Effects of Ginger (Zingiber officinale Roscoe) on Type 2Diabetes Mellitus and Components of the MetabolicSyndrome:A Systematic Review and Meta-Analysis of RandomizedControlled Trials. Evidence-Based Complementary and Alternative Medicine. 2018:1- 11.
Dhanik J, Arya N, Nand V. A Review on Zingiber officinale. Journal of Pharmacognosy and Phytochemistry 2017; 6(3): 174-184
de Lima A, Silva LS , Cavalcante, NAA,Campos TFGM. GENGIBRE (ZINGIBER OFFICINALE ROSCOE), PROPRIEDADESBIOATIVAS E SEU POSSÍVEL EFEITO NO DIABETES TIPO 2: ESTUDO DEREVISÃO. Rev. Saúde em Foco, Teresina, 2014 1,( 2): 15-25
Radwan Al Ali RA, Fawaz Mzayek F, Samer Rastam S, Fouad FM, O’Flaherty M4, Simon Capewell S et al Forecasting future prevalence of type 2 diabetesmellitus in Syria BMC Public Health 2013, 13:507
Nordström A, Hadrévi J, Olsson T, Franks PW, Nordström P. Higher Prevalence of Type 2 Diabetes in Men Thanin Women Is Associated With Differences inVisceral Fat MassJ Clin Endocrinol Metab, October 2016, 101(10):3740–3746
Demmer RT, Zuk AM, Rosenbaum M, Desvarieux M. Prevalence of Diagnosed and Undiagnosed Type 2 Diabetes Mellitus Among USAdolescents: Results From the Continuous NHANES, 1999–2010Am J Epidemiol. 2013;178(7):1106–1113
Diabetes https://www.who.int/es/news-room/fact-sheets/detail/diabetes data de acesso: 5 de outrubro de 2020.
Gengibre https://www.healthbenefitstimes.com/ginger/data de acesso 03 d3 outubro de 2020
Arzati MM, Honarvar NM, Saedisomeolia A, Anvari S,Effatpanah M, Arzat RM et al. The Effects of Ginger on Fasting Blood Sugar, Hemoglobin A1c, and Lipid Profiles in Patients with Type 2 Diabetes. Int J Endocrinol Metab. 2017 October; 15(4):e57927
Azizidoost S , Nazeri Z , Mohammadi A , Mohammadzadeh G , Cheraghzadeh M 1 , Jafari A et al.Effect of Hydroalcoholic Ginger Extract on Brain HMG-CoA Reductase and CYP46A1 Levels in Streptozotocin-induced Diabetic Rats. Avicenna Journal of Medical Biotechnology. 2019;11(3) 234-238.
Rahimlou M, Yari Z , Rayyani E, Keshavarz SA, Hosseini S, Morshedzadeh N , Hekmatdoost, A.Effects of ginger supplementation on anthropometric,glycemic and metabolic parameters in subjects with metabolicsyndrome: A randomized, double-blind, placebo-controlled study. Journal of Diabetes & Metabolic Disorders.2019,1;1-8.
Downloads
Published
How to Cite
Issue
Section
Categories
License
Copyright (c) 2022 RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218
This work is licensed under a Creative Commons Attribution 4.0 International License.
Os direitos autorais dos artigos/resenhas/TCCs publicados pertecem à revista RECIMA21, e seguem o padrão Creative Commons (CC BY 4.0), permitindo a cópia ou reprodução, desde que cite a fonte e respeite os direitos dos autores e contenham menção aos mesmos nos créditos. Toda e qualquer obra publicada na revista, seu conteúdo é de responsabilidade dos autores, cabendo a RECIMA21 apenas ser o veículo de divulgação, seguindo os padrões nacionais e internacionais de publicação.
